TY  - JOUR
A1  - Jonassen, Tanya
A1  - Proft, Markus
A1  - Randez-Gil, Francisca
A1  - Schultz, Jeffery R.
A1  - Marbois, Beth Noelle
A1  - Entian, Karl-Dieter
A1  - Clarke, Catherine F.
T1  - Yeast Clk-1 homologue (Coq7/Cat5) is a mitochondrial protein in coenzyme Q synthesis
T2  - Journal of biological chemistry
N2  - Mutations in the clk-1 gene result in slower development and increased life span in Caenorhabditis elegans. The Saccharomyces cerevisiae homologue COQ7/CAT5 is essential for several metabolic pathways including ubiquinone biosynthesis, respiration, and gluconeogenic gene activation. We show here that Coq7p/Cat5p is a mitochondrial inner membrane protein directly involved in ubiquinone biosynthesis, and that the defect in gluconeogenic gene activation in coq7/cat5 null mutants is a general consequence of a defect in respiration. These results obtained in the yeast model suggest that the effects on development and life span in C. elegans clk-1 mutants may relate to changes in the amount of ubiquinone, an essential electron transport component and a lipid soluble antioxidant.
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/75882
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-758820
SN  - 0021-9258
VL  - 273.1998
IS  - 6
SP  - 3351
EP  - 3357
PB  - American Society for Biochemistry and Molecular Biology Publications
CY  - Bethesda, Md
ER  -