TY  - JOUR
A1  - Häfner, Ann-Kathrin
A1  - Kahnt, Astrid Stefanie
A1  - Steinhilber, Dieter
T1  - Beyond leukotriene formation—the noncanonical functions of 5-lipoxygenase
T2  - Prostaglandins & other lipid mediators
N2  - 5-lipoxygenase (5-LO) is the key enzyme in the biosynthesis of leukotrienes and specialized proresolving lipid mediators (SPM). It is mainly expressed in leukocytes and is part of the innate immune system. 5-LO can shuttle between the cytosol and the nucleus. Upon cell activation the protein translocates from soluble cellular compartments to the nuclear membrane. Besides FLAP which is required for cellular leukotriene and SPM formation, 5-LO interacts with other proteins like coactosin-like protein (CLP), Dicer, β-catenin and p53. In this review, the factors involved in the regulation of 5-LO expression, the role of 5-LO in the regulation of stem cell proliferation and differentiation and its biological functions apart from leukotriene and SPM formation are summarized.
KW  - 5-Lipoxygenase
KW  - β-Catenin
KW  - Wnt
KW  - p53
KW  - Leukotriene
KW  - Dicer
KW  - SMAD
KW  - Vitamin D
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/48835
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-488356
SN  - 2212-196X
SN  - 1098-8823
N1  - © 2019 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/BY/4.0/).
VL  - 142
SP  - 24
EP  - 32
PB  - Elsevier
CY  - New York, NY
ER  -