TY  - JOUR
A1  - Glover, Natasha
A1  - Dessimoz, Christophe
A1  - Ebersberger, Ingo
A1  - Forslund, Sofia K.
A1  - Gabaldón, Toni
A1  - Huerta-Cepas, Jaime
A1  - Martin, Maria-Jesus
A1  - Muffato, Matthieu
A1  - Patricio, Mateus
A1  - Pereira, Cécile
A1  - Silva, Alan Wilter Sousa da
A1  - Wang, Yan
A1  - Sonnhammer, Erik
A1  - Thomas, Paul D.
T1  - Advances and applications in the quest for orthologs
T2  - Molecular biology and evolution
N2  - Gene families evolve by the processes of speciation (creating orthologs), gene duplication (paralogs), and horizontal gene transfer (xenologs), in addition to sequence divergence and gene loss. Orthologs in particular play an essential role in comparative genomics and phylogenomic analyses. With the continued sequencing of organisms across the tree of life, the data are available to reconstruct the unique evolutionary histories of tens of thousands of gene families. Accurate reconstruction of these histories, however, is a challenging computational problem, and the focus of the Quest for Orthologs Consortium. We review the recent advances and outstanding challenges in this field, as revealed at a symposium and meeting held at the University of Southern California in 2017. Key advances have been made both at the level of orthology algorithm development and with respect to coordination across the community of algorithm developers and orthology end-users. Applications spanned a broad range, including gene function prediction, phylostratigraphy, genome evolution, and phylogenomics. The meetings highlighted the increasing use of meta-analyses integrating results from multiple different algorithms, and discussed ongoing challenges in orthology inference as well as the next steps toward improvement and integration of orthology resources.
KW  - orthology
KW  - gene family
KW  - genome evolution
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/53320
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-533200
SN  - 1537-1719
SN  - 0737-4038
N1  - This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
VL  - 36
IS  - 10
SP  - 2157
EP  - 2164
PB  - Oxford Univ. Press
CY  - Oxford
ER  -