TY  - JOUR
A1  - Weber, Birte
A1  - Franz, Jan-Niklas
A1  - Marzi, Ingo
A1  - Henrich, Dirk
A1  - Leppik, Liudmila
T1  - Extracellular vesicles as mediators and markers of acute organ injury: current concepts
T2  - European journal of trauma and emergency surgery
N2  - Due to the continued high incidence and mortality rate worldwide, there is a need to develop new strategies for the quick, precise, and valuable recognition of presenting injury pattern in traumatized and poly-traumatized patients. Extracellular vesicles (EVs) have been shown to facilitate intercellular communication processes between cells in close proximity as well as distant cells in healthy and disease organisms. miRNAs and proteins transferred by EVs play biological roles in maintaining normal organ structure and function under physiological conditions. In pathological conditions, EVs change the miRNAs and protein cargo composition, mediating or suppressing the injury consequences. Therefore, incorporating EVs with their unique protein and miRNAs signature into the list of promising new biomarkers is a logical next step. In this review, we discuss the general characteristics and technical aspects of EVs isolation and characterization. We discuss results of recent in vitro, in vivo, and patients study describing the role of EVs in different inflammatory diseases and traumatic organ injuries. miRNAs and protein signature of EVs found in patients with acute organ injury are also debated.
KW  - Extracellular vesicles
KW  - Exosomes
KW  - Trauma
KW  - Organ injury
KW  - Systemic inflammation
KW  - MicroRNAs
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/63691
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-636911
SN  - 1863-9941
N1  - Open Access funding enabled and organized by Projekt DEAL.
VL  - 48
IS  - 3
SP  - 1525
EP  - 1544
PB  - Springer Medizin
CY  - Heidelberg
ER  -