TY  - JOUR
A1  - Zarnack, Katharina
A1  - Balasubramanian, Sureshkumar
A1  - Gantier, Michael P.
A1  - Kunetsky, Vladislav
A1  - Kracht, Michael
A1  - Schmitz, M. Lienhard
A1  - Sträßer, Katja
T1  - Dynamic mRNP remodeling in response to internal and external stimuli
T2  - Biomolecules
N2  - Signal transduction and the regulation of gene expression are fundamental processes in every cell. RNA-binding proteins (RBPs) play a key role in the post-transcriptional modulation of gene expression in response to both internal and external stimuli. However, how signaling pathways regulate the assembly of RBPs with mRNAs remains largely unknown. Here, we summarize observations showing that the formation and composition of messenger ribonucleoprotein particles (mRNPs) is dynamically remodeled in space and time by specific signaling cascades and the resulting post-translational modifications. The integration of signaling events with gene expression is key to the rapid adaptation of cells to environmental changes and stress. Only a combined approach analyzing the signal transduction pathways and the changes in post-transcriptional gene expression they cause will unravel the mechanisms coordinating these important cellular processes.
KW  - signal transduction
KW  - extracellular stimuli
KW  - intracellular stimuli
KW  - stress
KW  - post-transcriptional gene regulation
KW  - RNA-binding proteins (RBPs)
KW  - messenger ribonucleoprotein particles (mRNPs)
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/56309
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-563094
SN  - 2218-273X
VL  - 10
IS  - (9), 1310
PB  - MDPI
CY  - Basel
ER  -