TY  - JOUR
A1  - Olah, Csilla
A1  - Kubik, András
A1  - Mátrai, Péter
A1  - Engh, Marie Anne
A1  - Barna, Viktória
A1  - Hegyi, Péter
A1  - Reis, Henning
A1  - Nyirády, Péter
A1  - Szarvas, Tibor
T1  - Estimation of the incidence of urachal cancer: A systematic review and meta-analysis of registry-based studies
T2  - Urologic oncology : seminars and original investigations
N2  - Background: Urachal cancer (UrC) is a rare disease with limited availability of representative incidence and clinical data. Although, the prevalence is accounting for less than 1% of bladder tumors, the 5-year survival rate is around only 50% for patients with resectable tumors, and even worse for patients with metastatic disease. Due to the lack of comprehensive prospective studies, our current knowledge of UrC is still limited.
Objective: The present study aimed to summarize the available registry-based studies with unselected UrC patients to evaluate its incidence and clinicopathological characteristics.
Material and methods: We conducted a systematic literature search of registry-based UrC publications on the 15th of May 2023 in 5 databases, which identified 4,748 publications. After duplicate removal and selection by 2 independent investigators, 6 publications proved to be appropriate for the final meta-analysis. Estimated incidence and clinicopathological parameters were extracted.
Results: Estimated incidence ranged between 0.022 and 0.060/ 100.000 person-years, with the highest occurrence in Japan and the lowest in Canada, while the random effect model calculated an overall incidence rate of 0.04 (95%CI: 0.03–0.05) 100.000 person-years. The median age at first diagnosis was 60 years (range: 58–64). The female to male ratio was 2:3. Lymph node or distant metastases were present in 9% and 14% of patients. The predominant tumour type was adenocarcinoma (86%) followed by urothelial carcinoma (12%) and squamous cell carcinoma (2%). The 5-year survival rate was 51.0% with 95%CI: 45.2–57.4.
Conclusions: Our study provides an up-to-date comparison of estimated incidence rates between 6 countries of 3 continents based on rigorously selected registry-based studies. The results suggest low incidence rates for UrC with considerable geographic differences. The present meta-analysis provides unbiased registry-based data on the incidence, clinicopathological parameters and survival of UrC.
KW  - Urachal cancer
KW  - Urachus carcinoma
KW  - Incidence
KW  - Epidemiology
KW  - Registry
KW  - Adenocarcinoma
KW  - Bladder cancer
Y1  - 2024
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/83819
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-838196
SN  - 1078-1439
VL  - 2024
IS  - In Press, Corrected Proof
PB  - Elsevier
CY  - Amsterdam
ER  -