TY  - JOUR
A1  - Momic, Tatjana
A1  - Arlinghaus, Franziska Therese
A1  - Arien-Zakay, Hadar
A1  - Katzhendler, Jeoshua
A1  - Eble, Johannes A.
A1  - Marcinkiewicz, Cezary
A1  - Lazarovici, Philip
T1  - Pharmacological aspects of Vipera xantina palestinae venom
T2  - Toxins
N2  - In Israel, Vipera xantina palestinae (V.x.p.) is the most common venomous snake, accounting for several hundred cases of envenomation in humans and domestic animals every year, with a mortality rate of 0.5 to 2%. In this review we will briefly address the research developments relevant to our present understanding of the structure and function of V.x.p. venom with emphasis on venom disintegrins. Venom proteomics indicated the presence of four families of pharmacologically active compounds: (i) neurotoxins; (ii) hemorrhagins; (iii) angioneurin growth factors; and (iv) different types of integrin inhibitors. Viperistatin, a α1β1selective KTS disintegrin and VP12, a α2β1 selective C-type lectin were discovered. These snake venom proteins represent promising tools for research and development of novel collagen receptor selective drugs. These discoveries are also relevant for future improvement of antivenom therapy towards V.x.p. envenomation.
Y1  - 2011
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/24649
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-246494
SN  - 2072-6651
VL  - 3
IS  - 11
SP  - 1420
EP  - 1432
PB  - Molecular Diversity Preservation International (MDPI)
CY  - Basel
ER  -