TY  - JOUR
A1  - Navdaev, Alexey
A1  - Eble, Johannes A.
T1  - Components of cell-matrix linkage as potential new markers for prostate cancer
T2  - Cancers
N2  - Prostate cancer is one of the most common tumor diseases worldwide. Often being non-aggressive, prostate tumors in these cases do not need immediate treatment. However, about 20% of diagnosed prostate cancers tend to metastasize and require treatment. Existing diagnostic methods may fail to accurately recognize the transition of a dormant, non-aggressive tumor into highly malignant prostate cancer. Therefore, new diagnostic tools are needed to improve diagnosis and therapy of prostate carcinoma. This review evaluates existing methods to diagnose prostate carcinoma, such as the biochemical marker prostate-specific antigen (PSA), but also discusses the possibility to use the altered expression of integrins and laminin-332 in prostate carcinomas as diagnostic tools and therapeutic targets of prostate cancer.
KW  - prostate cancer
KW  - laminins
KW  - integrins
KW  - proteases
KW  - diagnosis
Y1  - 2012
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/25215
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-252151
SN  - 2072-6694
VL  - 3
IS  - 1
SP  - 883
EP  - 896
PB  - Molecular Diversity Preservation International (MDPI)
CY  - Basel
ER  -