TY  - JOUR
A1  - Oberoi-Khanuja, Tripat Kaur
A1  - Murali, Arun
A1  - Rajalingam, Krishnaraj
T1  - IAPs on the move : role of inhibitors of apoptosis proteins in cell migration
T2  - Cell death & disease
N2  - Inhibitors of Apoptosis Proteins (IAPs) are a class of highly conserved proteins predominantly known for the regulation of caspases and immune signaling. However, recent evidence suggests a crucial role for these molecules in the regulation of tumor cell shape and migration by controlling MAPK, NF-κB and Rho GTPases. IAPs directly control Rho GTPases, thus regulating cell shape and migration. For instance, XIAP and cIAP1 function as the direct E3 ubiquitin ligases of Rac1 and target it for proteasomal degradation. IAPs are differentially expressed in tumor cells and have been targeted by several cancer therapeutic drugs that are currently in clinical trials. Here, we summarize the current knowledge on the role of IAPs in the regulation of cell migration and discuss the possible implications of these observations in regulating tumor cell metastases.
KW  - IAPs
KW  - XIAP
KW  - cIAP1 BIR
KW  - tumour
KW  - migration
KW  - metastases
Y1  - 2013
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/29309
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-293093
SN  - 2041-4889
N1  - Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by/3.0/
VL  - 4
IS  - 784
PB  - Nature Publishing Group
CY  - London [u.a.]
ER  -