TY  - JOUR
A1  - Lang, Fabian
A1  - Wojcik, Bartosch
A1  - Bothur, Sabrina
A1  - Knecht, Christian
A1  - Falkenburg, J. H. Frederik
A1  - Schroeder, Timm
A1  - Serve, Hubert
A1  - Ottmann, Oliver G.
A1  - Rieger, Michael A.
T1  - Plastic CD34 and CD38 expression in adult B-cell precursor acute lymphoblastic leukemia explains ambiguity of leukemia-initiating stem cell populations
T2  - Leukemia
N2  - B-cell precursor acute lymphoblastic leukemia (BCP-ALL) is an aggressive hematologic malignancy of bone-marrow (BM)-derived lymphoid precursor cells at various stages of differentiation. Although first-line therapy with chemotherapy and—in the case of BCR-ABL1 positive ALL—tyrosine kinase inhibitors is initially highly effective with remission rates of >90%, the overall survival rate in adult patients is 40–50% across all risk groups. Relapse originates from putative leukemia-initiating cells (LICs) that are intrinsically resistant to chemotherapeutic regimens, which may explain the poor long-term prognosis of patients with disease recurrence. Eradication of LICs thus is a principal aim of novel therapeutic approaches. A prerequisite for developing effective LIC-targeted treatments is the ability to identify and clinically monitor LICs in ALL, a goal that has to date been elusive. The existence, phenotype, biological properties and the hierarchical organization of LICs in BCP-ALL remain highly controversial. ...
Y1  - 2017
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/44708
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-447087
SN  - 1476-5551
SN  - 0887-6924
N1  - This work is licensed under a Creative Commons AttributionNonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http:// creativecommons.org/licenses/by-nc-sa/4.0/
VL  - 31
IS  - 3
SP  - 731
EP  - 734
PB  - Springer Nature
CY  - London
ER  -