TY  - JOUR
A1  - Wesche, Frank
A1  - Adihou, Hélène
A1  - Wichelhaus, Thomas Alexander
A1  - Bode, Helge Björn
T1  - Synthesis and SAR of the antistaphylococcal natural product nematophin from Xenorhabdus nematophila
T2  - Beilstein journal of organic chemistry
N2  - The repeated and improper use of antibiotics had led to an increased number of multiresistant bacteria. Therefore, new lead structures are needed. Here, the synthesis and an expanded structure–activity relationship of the simple and antistaphylococcal amide nematophin from Xenorhabdus nematophila and synthetic derivatives are described. Moreover, the synthesis of intrinsic fluorescent derivatives, incorporating azaindole moieties was achieved for the first time.
KW  - azaindole
KW  - fluorescent dye
KW  - MRSA
KW  - nematophin
KW  - Staphylococcus aureus
Y1  - 2019
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/48811
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-488112
SN  - 1860-5397
N1  - This is an Open Access article under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0). Please note that the reuse, redistribution and reproduction in particular requires that the authors and source are credited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc)
VL  - 15
SP  - 535
EP  - 541
PB  - Beilstein-Institut zur Förderung der Chemischen Wissenschaften
CY  - Frankfurt, Main
ER  -