TY  - JOUR
A1  - Köllensperger, Eva
A1  - Niesen, Willem
A1  - Kolbenschlag, Jonas
A1  - Gramley, Felix
A1  - Germann, Günter
A1  - Leimer, Uwe
T1  - Human adipose tissue derived stem cells promote liver regeneration in a rat model of toxic injury
T2  - Stem cells international
N2  - In the light of the persisting lack of donor organs and the risks of allotransplantations, the possibility of liver regeneration with autologous stem cells from adipose tissue (ADSC) is an intriguing alternative. Using a model of a toxic liver damage in Sprague Dawley rats, generated by repetitive intraperitoneal application of retrorsine and allyl alcohol, the ability of human ADSC to support the restoration of liver function was investigated. A two-thirds hepatectomy was performed, and human ADSC were injected into one remaining liver lobe in group 1 (n = 20). Injection of cell culture medium performed in group 2 (n = 20) served as control. Cyclosporine was applied to achieve immunotolerance. Blood samples were drawn weekly after surgery to determine liver-correlated blood values. Six and twelve weeks after surgery, animals were sacrificed and histological sections were analyzed. ADSC significantly raised postoperative albumin (P < 0.017), total protein (P < 0.031), glutamic oxaloacetic transaminase (P < 0.001), and lactate dehydrogenase (P < 0.04) levels compared to injection of cell culture medium alone. Transplanted cells could be found up to twelve weeks after surgery in histological sections. This study points towards ADSC being a promising alternative to hepatocyte or liver organ transplantation in patients with severe liver failure.
Y1  - 2013
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/50505
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-505051
SN  - 1687-966X
SN  - 1687-9678
N1  - Copyright © 2013 Eva Koellensperger et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
VL  - 2013
IS  - Art. 534263
SP  - 1
EP  - 10
PB  - Sage-Hindawi
CY  - London [u. a.]
ER  -