TY  - JOUR
A1  - Han, Dan
A1  - Wang, Ran
A1  - Yu, Yang
A1  - Sun, Mingyu
A1  - Teschke, Rolf
A1  - Romeiro, Fernando Gomes
A1  - Mancuso, Andrea
A1  - Song, Tingxue
A1  - Peng, Zhong
A1  - Han, Bing
A1  - Zhou, Xinmiao
A1  - Bao, Wenchun
A1  - Li, Qianqian
A1  - Zheng, Kexin
A1  - Li, Yingying
A1  - Bai, Zhaohui
A1  - Guo, Xiaozhong
A1  - Qi, Xingshun
T1  - Xuebijing injection combined with antibiotics for the treatment of spontaneous bacterial peritonitis in liver cirrhosis : a meta-analysis
T2  - Evidence-based complementary and alternative medicine
N2  - Background and Aim. Spontaneous bacterial peritonitis (SBP) is one of the most common complications of liver cirrhosis. Antibiotics are the main treatment regimen of SBP. Traditional Chinese medicine Xuebijing injection has been used in such patients. Our study aimed to overview the efficacy of Xuebijing injection combined with antibiotics for the treatment of SBP.
Method. We searched the PubMed, Embase, China National Knowledge Infrastructure, VIP, and Wanfang databases. The search items included "Xuebijing", "peritonitis", "liver cirrhosis", and "random" to identify all relevant randomized controlled trials (RCTs). The Cochrane risk of bias tool was used to assess the study quality. The odd ratios (ORs) with 95% confidence intervals (CIs) were calculated by using a random-effect model. Heterogeneity was also calculated.
Results. A total of 9 RCTs were included. The study quality was unsatisfied. The overall (OR = 2.95, 95% CI = 1.97–4.42, p<0.00001) and complete (OR = 2.18, 95% CI = 1.57–3.04, p<0.00001) responses were significantly higher in the Xuebijing injection combined with antibiotics group than the antibiotics alone group. The incidence of cirrhosis related complications, including hepatic encephalopathy and hepatorenal syndrome, was lower in the Xuebijing injection combined with antibiotics group than the antibiotics alone group. No significant heterogeneity was observed among studies.
Conclusion. Additional use of Xuebijing injection may improve the efficacy of antibiotics for the treatment of SBP in liver cirrhosis. However, due to a low level of current evidence, we did not establish any recommendation regarding the use of Xuebijing injection for the treatment of SBP.
Y1  - 2018
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/50745
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-507456
SN  - 1741-4288
SN  - 1741-427X
N1  - Copyright © 2018 Dan Han et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
VL  - 2018
IS  - Art. 2989846
SP  - 1
EP  - 10
PB  - Hindawi
CY  - New York, NY
ER  -