TY  - JOUR
A1  - Krieg, Stephanie
A1  - Ullrich, Evelyn
T1  - Novel immune modulators used in hematology: impact on NK cells
T2  - Frontiers in Immunology
N2  - There is a wide range of important pharmaceuticals used in treatment of cancer. Besides their known effects on tumor cells, there is growing evidence for modulation of the immune system. Immunomodulatory drugs (IMiDs®) play an important role in the treatment of patients with multiple myeloma or myelodysplastic syndrome and have already demonstrated antitumor, anti-angiogenic, and immunostimulating effects, in particular on natural killer (NK) cells. Tyrosine kinase inhibitors are directly targeting different kinases and are known to regulate effector NK cells and expression of NKG2D ligands (NKG2DLs) on tumor cells. Demethylating agents, histone deacetylases, and proteasome inhibitors interfere with the epigenetic regulation and protein degradation of malignant cells. There are first hints that these drugs also sensitize tumor cells to chemotherapy, radiation, and NK cell-mediated cytotoxicity by enhanced expression of TRAIL and NKG2DLs. However, these pharmaceuticals may also impair NK cell function in a dose- and time-dependent manner. In summary, this review provides an update on the effects of different novel molecules on the immune system focusing NK cells.
KW  - NK cell
KW  - IMiD®
KW  - TKI
KW  - Glivec®
KW  - bortezomib
KW  - thalidomide
KW  - lenalidomide
KW  - HDACi
Y1  - 2013
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/51865
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-518655
VL  - 3
IS  - 388
PB  - Frontiers Research Foundation
CY  - Lausanne
ER  -