TY  - JOUR
A1  - Nielsen, Marlene Christina
A1  - Hvidbjerg Gantzel, Rasmus
A1  - Clària, Joan
A1  - Trebicka, Jonel
A1  - Møller, Holger Jon
A1  - Grønbæk, Henning
T1  - Macrophage activation markers, CD163 and CD206, in acute-on-chronic liver failure
T2  - Cells
N2  - Macrophages facilitate essential homeostatic functions e.g., endocytosis, phagocytosis, and signaling during inflammation, and express a variety of scavenger receptors including CD163 and CD206, which are upregulated in response to inflammation. In healthy individuals, soluble forms of CD163 and CD206 are constitutively shed from macrophages, however, during inflammation pathogen- and damage-associated stimuli induce this shedding. Activation of resident liver macrophages viz. Kupffer cells is part of the inflammatory cascade occurring in acute and chronic liver diseases. We here review the existing literature on sCD163 and sCD206 function and shedding, and potential as biomarkers in acute and chronic liver diseases with a particular focus on Acute-on-Chronic Liver Failure (ACLF). In multiple studies sCD163 and sCD206 are elevated in relation to liver disease severity and established as reliable predictors of morbidity and mortality. However, differences in expression- and shedding-stimuli for CD163 and CD206 may explain dissimilarities in prognostic utility in patients with acute decompensation of cirrhosis and ACLF.
KW  - macrophage
KW  - scavenger receptor
KW  - sCD163
KW  - sCD206
KW  - inflammation
KW  - chronic liver disease
KW  - acute decompensation of cirrhosis
KW  - liver cirrhosis
KW  - acute-on-chronic liver failure
KW  - ACLF
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/54810
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-548108
SN  - 2073-4409
VL  - 9
IS  - 1175
PB  - MDPI
CY  - Basel
ER  -