TY  - JOUR
A1  - Osiewacz, Heinz D.
A1  - Schürmanns, Lea
T1  - A network of pathways controlling cellular homeostasis affects the onset of senescence in Podospora anserina
T2  - Journal of Fungi
N2  - Research on Podospora anserina unraveled a network of molecular pathways affecting biological aging. In particular, a number of pathways active in the control of mitochondria were identified on different levels. A long-known key process active during aging of P. anserina is the age- related reorganization of the mitochondrial DNA (mtDNA). Mechanisms involved in the stabilization of the mtDNA lead to lifespan extension. Another critical issue is to balance mitochondrial levels of reactive oxygen species (ROS). This is important because ROS are essential signaling molecules, but at increased levels cause molecular damage. At a higher level of the network, mechanisms are active in the repair of damaged compounds. However, if damage passes critical limits, the corresponding pathways are overwhelmed and impaired molecules as well as those present in excess are degraded by specific enzymes or via different forms of autophagy. Subsequently, degraded units need to be replaced by novel functional ones. The corresponding processes are dependent on the availability of intact genetic information. Although a number of different pathways involved in the control of cellular homeostasis were uncovered in the past, certainly many more exist. In addition, the signaling pathways involved in the control and coordination of the underlying pathways are only initially understood. In some cases, like the induction of autophagy, ROS are active. Additionally, sensing and signaling the energetic status of the organism plays a key role. The precise mechanisms involved are elusive and remain to be elucidated.
KW  - aging
KW  - autophagy
KW  - homeostasis
KW  - mitochondria
KW  - peroxisomes
KW  - Podospora anserina
KW  - quality control
KW  - signaling
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/61120
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-611208
SN  - 2309-608X
VL  - 7
IS  - 4, art. 263
SP  - 1
EP  - 16
PB  - MDPI
CY  - Basel
ER  -