TY  - JOUR
A1  - Pliquett, Rainer U.
A1  - Brandes, Ralf
T1  - Experimental uninephrectomy associates with less parasympathetic modulation of heart rate and facilitates sodium-dependent arterial hypertension
T2  - PLOS ONE
N2  - Background: Blood pressure is known to be increased in kidney donors following living-donor kidney transplantation. However, the physiological underpinnings of the blood-pressure increase following uninephrectomy remain unclear. We hypothesized that changes in sympathetic tone or in parasympathetic modulation of sinus node function are involved in the blood-pressure increase following experimental kidney-mass reduction.
Methods: C57BL6N mice (6 to 11 per group) subjected to sham surgery (controls) or uninephrectomy with or without a one-week course of sodium chloride-enriched, taurine-deficient diet were studied. Uninephrectomized mice treated with a subcutaneous infusion of angiotensin-II over a period of one week were positive controls. A transfemoral aortic catheter with telemetry unit was implanted, readings of heart-rate and blood-pressure were recorded. Powerspectral analysis of heart rate and systolic blood pressure was performed to gain surrogate parameters of sympathetictone and parasympathetic modulation of sinus node function. Baroreflex sensitivity of heart rate was determined from awake, unrestrained mice using spontaneous baroreflex gain technique.
Results: Systolic arterial blood pressure, heart rate and baroreflex sensitivity were not different in uninephrectomized mice when compared to controls. Parasympathetic modulation of sinus node function was less in uninephrectomized mice in comparison to controls. Uninephrectomized mice of the high-angiotensin-II model or of the high-salt and taurine-deficiency model had an increased systolic arterial blood pressure.
Conclusions: Uninephrectomy associated with less parasympathetic modulation of sinus node function. The combination of uninephrectomy, taurine-deficiency and high-salt intake led to arterial hypertension.
KW  - Blood pressure
KW  - Hypertension
KW  - Heart rate
KW  - Mouse models
KW  - Kidneys
KW  - Diet
KW  - Hypertensive disorders in pregnancy
KW  - Sodium chloride
Y1  - 2022
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/62704
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-627043
SN  - 1932-6203
N1  - RUP received grant from "Deutsche Nierenstiftung" 2008 (https://www.nierenstiftung.de). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
VL  - 17
IS  - e0265086
SP  - 1
EP  - 10
PB  - PLOS
CY  - San Francisco, California, US
ER  -