TY  - JOUR
A1  - Ademmer, Vanessa
A1  - Agha, Bishr
A1  - Shajari, Mehdi
A1  - Kohnen, Thomas
A1  - Schmack, Ingo
T1  - Impact of DMEK on visual quality in patients with Fuchs' endothelial dystrophy
T2  - Graefe's archive for clinical and experimental ophthalmology
N2  - Purpose: To investigate short-term (3 months follow-up) changes in visual quality following Descemet membrane endothelial keratoplasty (DMEK) for Fuchs endothelial dystrophy (FED). Methods: In this prospective institutional case series, 51 patients that underwent DMEK for FED were included. Assessment included the Quality of Vision (QoV) questionnaire preoperatively, at 1 month, and 3 months after surgery. Secondary outcome measures were anterior segment parameters acquired by Scheimpflug imaging, corrected distance visual acuity (CDVA), and endothelial cell density (ECD). Results: Glare, hazy vision, blurred vision, and daily fluctuation in vision were the symptoms mostly reported preoperatively. All symptoms demonstrated a significant reduction of item scores for severity, frequency, and bothersome in the course after DMEK (P < 0.01). Glare and fluctuation in vision remained to some extent during the follow-up period (median score = 1). Preoperatively, corneal densitometry correlated moderately to weakly with severity of hazy vision (rs = 0.39; P = 0.03) and frequency (rs = 0.26; P = 0.02) as well as severity (rs = 0.27; P = 0.03) of blurry vision. CDVA and central corneal thickness (CCT) did not correlate with visual complains. Conclusions: Following DMEK for FED, patient-reported visual symptoms assessed by the QoV questionnaire represent a useful tool providing valuable information on the impact of DMEK on visual quality that cannot be directly estimated by morphological parameters and visual acuity only.
KW  - DMEK
KW  - Fuchs endothelial dystrophy
KW  - Visual quality
KW  - Scheimpflug imaging
Y1  - 2021
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/64017
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-640177
SN  - 1435-702X
N1  - Early View: Online Version before inclusion in an issue.
VL  - 2021
IS  - online version before inclusion in an issue
PB  - Springer
CY  - Berlin ; Heidelberg
ER  -