TY  - JOUR
A1  - Zimmermann, Herbert
T1  - Ectonucleoside triphosphate diphosphohydrolases and ecto-5'-nucleotidase in purinergic signaling: how the field developed and where we are now
T2  - Purinergic signalling
N2  - Geoffrey Burnstock will be remembered as the scientist who set up an entirely new field of intercellular communication, signaling via nucleotides. The signaling cascades involved in purinergic signaling include intracellular storage of nucleotides, nucleotide release, extracellular hydrolysis, and the effect of the released compounds or their hydrolysis products on target tissues via specific receptor systems. In this context ectonucleotidases play several roles. They inactivate released and physiologically active nucleotides, produce physiologically active hydrolysis products, and facilitate nucleoside recycling. This review briefly highlights the development of our knowledge of two types of enzymes involved in extracellular nucleotide hydrolysis and thus purinergic signaling, the ectonucleoside triphosphate diphosphohydrolases, and ecto-5′-nucleotidase.
KW  - Adenosine
KW  - ATP
KW  - Ecto-5'-nucleotidase
KW  - E-NTPDase
KW  - Geoffrey Burnstock
KW  - History
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/63579
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-635790
SN  - 1573-9546
N1  - Open Access funding enabled and organized by Projekt DEAL.
VL  - 17
IS  - 1
SP  - 117
EP  - 125
PB  - Springer Science + Business Media B.V.
CY  - Dordrecht
ER  -