TY  - JOUR
A1  - Wilk, Manfred
A1  - Schmitt, Karlheinz
T1  - Aktivierung von Steroidsystemen zu alkylierenden Agenzien
T1  - Activation of steroid systems to alkylating agents
T2  - Zeitschrift für Naturforschung, B
N2  - 7-Dehydrocholesterol and ergosterol are oxidised by iodine and FeCl3 under "physiologically similar" conditions to highly reactive alkylating species. These can be trapped by nucleophiles, such as 1-methylimidazole.
The oxidation of the sterols to those alkylating species is discussed as a model-reaction for the first step in chemical carcinogenesis by endogene substrates.
KW  - Oxidation
KW  - 7-Dehydrocholesterol
KW  - Endogene Carcinogenesis
Y1  - 2014
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/69860
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-698603
SN  - 1865-7117
SN  - 0932-0776
VL  - 36
IS  - 2
SP  - 248
EP  - 251
PB  - Verlag der Zeitschrift für Naturforschung
CY  - Tübingen
ER  -