TY  - INPR
A1  - Hou, Liping
A1  - Bergen, Sarah E.
A1  - Akula, Nirmala
A1  - Song, Jie
A1  - Hultman, Christina M.
A1  - Landén, Mikael
A1  - Adli, Mazda
A1  - Alda, Martin
A1  - Ardau, Raffaella
A1  - Arias, Bárbara
A1  - Aubry, Jean-Michel
A1  - Backlund, Lena
A1  - Badner, Judith A.
A1  - Barrett, Thomas B.
A1  - Bauer, Michael
A1  - Baune, Bernhard T.
A1  - Bellivier, Frank
A1  - Benabarre Hernandez, Antonio
A1  - Bengesser, Susanne
A1  - Berrettini, Wade H.
A1  - Bhattacharjee, Abesh Kumar
A1  - Biernacka, Joanna
A1  - Birner, Armin
A1  - Bloss, Cinnamon S.
A1  - Brichant-Petitjean, Clara
A1  - Bui, Elise T.
A1  - Byerley, William
A1  - Cervantes, Pablo
A1  - Chillotti, Caterina
A1  - Cichon, Sven
A1  - Colom, Francesc
A1  - Coryell, William
A1  - Craig, David W.
A1  - Cruceanu, Cristiana
A1  - Czerski, Piotr M.
A1  - Davis, Tony
A1  - Dayer, Alexandre
A1  - Degenhardt, Franziska
A1  - Del Zompo, Maria
A1  - DePaulo, J. Raymond
A1  - Edenberg, Howard J.
A1  - Étain, Bruno
A1  - Falkai, Peter
A1  - Foroud, Tatiana
A1  - Forstner, Andreas Josef
A1  - Frisén, Louise
A1  - Frye, Mark A.
A1  - Fullerton, Janice M.
A1  - Gard, Sébastien
A1  - Garnham, Julie S.
A1  - Gershon, Elliot S.
A1  - Goes, Fernando S.
A1  - Greenwood, Tiffany A.
A1  - Grigoroiu-Serbanescu, Maria
A1  - Hauser, Joanna
A1  - Heilbronner, Urs
A1  - Heilmann-Heimbach, Stefanie
A1  - Herms, Stefan
A1  - Hipolito, Maria
A1  - Hitturlingappa, Shashi
A1  - Hoffmann, Per
A1  - Hofmann, Andrea
A1  - Jamain, Stephane
A1  - Jiménez, Esther
A1  - Kahn, Jean-Pierre
A1  - Kassem, Layla
A1  - Kelsoe, John R.
A1  - Kittel-Schneider, Sarah
A1  - Kliwicki, Sebastian
A1  - Koller, Daniel L.
A1  - König, Barbara
A1  - Lackner, Nina
A1  - Laje, Gonzalo
A1  - Lang, Maren
A1  - Lavebratt, Catharina
A1  - Lawson, William B.
A1  - Leboyer, Marion
A1  - Leckband, Susan G.
A1  - Liu, Chunyu
A1  - Maaser, Anna
A1  - Mahon, Pamela B.
A1  - Maier, Wolfgang
A1  - Maj, Mario
A1  - Manchia, Mirko
A1  - Martinsson, Lina
A1  - McCarthy, Michael J.
A1  - McElroy, Susan L.
A1  - McInnis, Melvin G.
A1  - McKinney, Rebecca
A1  - Mitchell, Philip B.
A1  - Mitjans, Marina
A1  - Mondimore, Francis Mark
A1  - Monteleone, Palmiero
A1  - Mühleisen, Thomas W.
A1  - Nievergelt, Caroline M.
A1  - Nöthen, Markus Maria
A1  - Novák, Tomas
A1  - Nurnberger, John I.
A1  - Nwulia, Evaristus A.
A1  - Ösby, Urban
A1  - Pfennig, Andrea
A1  - Potash, James B.
A1  - Propping, Peter
A1  - Reif, Andreas
A1  - Reininghaus, Eva
A1  - Rice, John
A1  - Rietschel, Marcella
A1  - Rouleau, Guy A.
A1  - Rybakowski, Janusz K.
A1  - Schalling, Martin
A1  - Scheftner, William A.
A1  - Schofield, Peter R.
A1  - Schork, Nicholas J.
A1  - Schulze, Thomas Gerd
A1  - Schumacher, Johannes
A1  - Schweizer, Barbara W.
A1  - Severino, Giovanni
A1  - Shekhtman, Tatyana
A1  - Shilling, Paul D.
A1  - Simhandl, Christian
A1  - Slaney, Claire M.
A1  - Smith, Erin N.
A1  - Squassina, Alessio
A1  - Stamm, Thomas
A1  - Stopkova, Pavla
A1  - Streit, Fabian
A1  - Strohmaier, Jana
A1  - Szelinger, Szabolcs
A1  - Tighe, Sarah K.
A1  - Tortorella, Alfonso
A1  - Turecki, Gustavo
A1  - Vieta, Eduard
A1  - Volkert, Julia
A1  - Witt, Stephanie H.
A1  - Wright, Adam
A1  - Zandi, Peter P.
A1  - Zhang, Peng
A1  - Zollner, Sebastian
A1  - McMahon, Francis J.
T1  - Genome-wide association study of 40,000 individuals identifies two novel loci associated with bipolar disorder
N2  - Bipolar disorder (BD) is a genetically complex mental illness characterized by severe oscillations of mood and behavior. Genome-wide association studies (GWAS) have identified several risk loci that together account for a small portion of the heritability. To identify additional risk loci, we performed a two-stage meta-analysis of >9 million genetic variants in 9,784 bipolar disorder patients and 30,471 controls, the largest GWAS of BD to date. In this study, to increase power we used ~2,000 lithium-treated cases with a long-term diagnosis of BD from the Consortium on Lithium Genetics, excess controls, and analytic methods optimized for markers on the Xchromosome. In addition to four known loci, results revealed genome-wide significant associations at two novel loci: an intergenic region on 9p21.3 (rs12553324, p = 5.87×10-9; odds ratio = 1.12) and markers within ERBB2 (rs2517959, p = 4.53×10-9; odds ratio = 1.13). No significant X-chromosome associations were detected and X-linked markers explained very little BD heritability. The results add to a growing list of common autosomal variants involved in BD and illustrate the power of comparing well-characterized cases to an excess of controls in GWAS.
Y1  - 2016
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/72382
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-723824
N1  - Preprint, später in Human Molecular Genetics doi: 10.1093/hmg/ddw181
ER  -