TY  - INPR
A1  - Dapergola, Eleni
A1  - Menegazzi, Pamela
A1  - Raabe, Thomas
A1  - Hovhanyan, Anna
T1  - Light stimuli and circadian clock affect neural development in Drosophila melanogaster
T2  - bioRxiv
N2  - Endogenous clocks enable organisms to adapt their physiology and behavior to daily variation in environmental conditions. Metabolic processes in cyanobacteria to humans are effected by the circadian clock, and its dysregulation causes metabolic disorders. In mouse and Drosophila were shown that the circadian clock directs translation of factors involved in ribosome biogenesis and synchronizes protein synthesis. However, the role of clocks in Drosophila neurogenesis and the potential impact of clock impairment on neural circuit formation and function is less understood. Here we demonstrate that light stimuli or circadian clock causes a defect in neural stem cell growth and proliferation accompanied by reduced nucleolar size. Further, we define that light and clock independently affect the InR/TOR growth regulatory pathway due to the effect on regulators of protein biosynthesis. Altogether, these data suggest that alterations in growth regulatory pathways induced by light and clock are associated with impaired neural development.
Y1  - 2020
UR  - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/72811
UR  - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-728116
IS  - 2020.08.07.241208
ER  -