TY - JOUR A1 - Kienitz, Ricardo A1 - Kouroupaki, Kleopatra A1 - Schmid, Michael Christoph T1 - Microstimulation of visual area V4 improves visual stimulus detection T2 - Cell Reports N2 - Highlights • Microstimulation of visual area V4 improves visual stimulus detection • Effects of V4 microstimulation extend to the other hemifield • Microstimulation effects are time dependent and consistent with attention dynamics Summary Neuronal activity in visual area V4 is well known to be modulated by selective attention, and there are reports on V4 lesions leading to attentional deficits. However, it remains unclear whether V4 microstimulation can elicit attentional benefits. To test this hypothesis, we performed local microstimulation in area V4 and explored its spatial and time dynamics in two macaque monkeys performing a visual detection task. Microstimulation was delivered via chronically implanted multi-electrode arrays. We found that microstimulation increases average performance by 35% and reduces luminance detection thresholds by −30%. This benefit critically depends on the onset of microstimulation relative to the stimulus, consistent with known dynamics of endogenous attention. These results show that local microstimulation of V4 can improve behavior and highlight the critical role of V4 for attention. KW - attention KW - microstimulation KW - visual cortex KW - V4 KW - macaque KW - detection task Y1 - 2022 UR - http://publikationen.ub.uni-frankfurt.de/frontdoor/index/index/docId/78406 UR - https://nbn-resolving.org/urn:nbn:de:hebis:30:3-784061 SN - 2211-1247 VL - 40 IS - 12, 111392 PB - Elsevier CY - Amsterdam ER -