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["Table","Description"]
["Table S1","Summary of 57 cohorts included in the Psychiatric Genomics Consortium bipolar disorder GWAS (adapted from Mullins et al., Nat Genet, 2021)."]
["Table S2","Genome-wide significant loci for bipolar disorder showing the most significant SNP from each genomic region (adapted from Mullins et al., Nat Genet, 2021)"]
["Table S3","Results of conditional analysis in each BD risk locus using GCTA-COJO and GWAS summary statistics."]
["Table S4","Number of SNPs (PIP >0.95) per GWS locus across fine-mapping methods, LD reference panels and fine-mapping windows."]
["Table S5","Genomic annotations and functional consequences of fine-mapped SNPs."]
["Table S6","Significant SMR results from BrainMeta eQTL and sQTL data and Brain-mMETA mQTL data for union consensus SNPs."]
["Table S7","HLA variants with P < 5e-06 for association with bipolar disorder. "]
["Table S8","HLA variants with P < 1E-03, for association with bipolar disorder within the extended MHC locus (chr6:20,000,000-40,000,000), after conditioning on rs35202262."]
["Table S9","Polygenic risk score analysis results for European and non European bipolar disorder cohorts."]

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["Supplementary Table 1: Summary of 57 cohorts included in the Psychiatric Genomics Consortium bipolar disorder GWAS (adapted from Mullins et al., Nat Genet, 2021)"]
["Sample abbreviation^","Principal Investigators","Sample Name","Country of ascertainment","Case N","Control N","N eff half","Name of relevant ethics committee(s) or recruitment site(s)","Ethics approved/ waived"]
["bmau","Fullerton JM, Mitchell PB, Schofield PR, Martin NG","BOMA-Australia","Australia",329.0,1810.0,556.0,"Cases: Mood Disorder Unit, Prince of Wales Hospital in Sydney & UNSW Human Research Ethics Committee (HREC12623, HREC09394). Controls: Queensland Institute of Medical Research","approved"]
["bmg2","Rietschel M, Nöthen MM, Schulze TG, Forstner AJ","BOMA-Germany II","Germany",181.0,478.0,262.0,"University Hospital Würzburg, Ethics Committee of the Medical Faculty of the University of Essen","approved"]
["bmg3","Rietschel M, Nöthen MM, Schulze TG, Forstner AJ","BOMA-Germany III","Germany",489.0,880.0,628.0,"Central Institute of Mental Health in Mannheim, University of Heidelberg, Max-Planck Institute of Psychiatry, Munich","approved"]
["bmpo","Hauser J, Lissowska J, Forstner AJ","BOMA-Poland","Poland",410.0,689.0,514.0,"Department of Psychiatry, Poznan University of Medical Sciences, Cancer-Center and Institute of Oncology, Warsaw, Nofer Institute of Occupational Medicine, Lodz","approved"]
["bmsp","Rietschel M, Nöthen MM, Mayoral F","BOMA-Spain","Spain",253.0,291.0,270.0,"Cases: Regional University Hospital of Malaga, University Hospital Reina Sofia of Córdoba, Provincial Hospital of Jaen; Hospital of Jerez de la Frontera (Cádiz); Hospital of Puerto Real (Cádiz); Hospital Punta Europa of Algeciras (Cádiz); and Hospital Universitario San Cecilio (Granada), Controls: Comité ético de Investigación Clínica (CEIC), Instituto Municipal de Asistencia Sanitaria, IMAS-IMIM, Barcelona","approved"]
["bonn","Rietschel M, Nöthen MM, Cichon S","BOMA-Germany I","Germany",669.0,1246.0,870.0,"Cases: Department of Psychiatry and Psychotherapy at the University of Bonn, Central Institute of Mental Health in Mannheim, University of Heidelberg; Controls: Medical Faculty of Kiel (PopGen), Ethics Committee of the Bavarian Medical Association (KORA), Ethics Committee of the Medical Faculty of the University of Essen (Heinz Nixdorf Recall study)","approved"]
["dub1","Corvin A","Trinity College Dublin","Ireland",150.0,796.0,252.0,"Cases: Trinity College Dublin, Controls: Irish GeneBank","approved"]
["edi1","Blackwood D","University of Edinburgh","Scotland",275.0,272.0,273.0,"Multi-Centre Research Ethics Committee for Scotland","approved"]
["fat2","Sklar P, Smoller J (FaST); Kelsoe J (TGEN)","FaST, TGEN1,2","USA",722.0,1027.0,847.0,"Indiana University, John Hopkins University, the NIMH Intramural Research Program, Washington University at St. Louis, University of Pennsylvania, University of Chicago, Rush Medical School, University of Iowa, University of California, San Diego, University of California, San Francisco, and University of Michigan","approved"]
["fran","Leboyer M","French","France",451.0,1630.0,706.0,"Pitie ́-Salpetriere Hospital in Paris","approved"]
["gain","Kelsoe J","BiGs: Genetic Association Information Network (GAIN)","USA",706.0,593.0,644.0,"Indiana University, John Hopkins University, the NIMH Intramural Research Program, Washington University at St. Louis, University of Pennsylvania, University of Chicago, Rush Medical School, University of Iowa, University of California, San Diego, University of California, San Francisco, and University of Michigan","approved"]
["gsk1","Vincent J","BACCS","USA",706.0,899.0,790.0,"Centre for Addiction & Mental Health Research Ethics Board in Toronto, College Research Ethics Committee King's College London","approved"]
["hal2","Alda M (Nova Scotia); Perlis R, Smoller J (shared controls)","Nova Scotia, MGH i2b2 controls","Canada/USA",410.0,479.0,441.0,"Cases: Specialty mood disorders clinics in Halifax and Ottawa (Canada), Controls: Massachusetts General Hospital Institutional Review Board","cases: approved, controls: waived"]
["icuk","O'Donovan M, Di Florio A, Craddock N, Jones L, Jones I","International Cohort Collection for Bipolar Disorder (ICCBD) Bipolar Disorder Research Network (BDRN)","UK",2456.0,4069.0,3063.0,"West Midlands Multi-Centre Research Ethics Committee","approved"]
["jst5","Li Q (Janssen); Ripke S (shared controls)","Janssen, SAGE controls","USA",646.0,643.0,644.0,"Cases: Clinical trials (IDs: NCT00253162, NCT00257075, NCT00076115, NCT00299715, NCT00309699, and NCT00309686) conducted by Janssen Research & Development, LLC, institutional review board or human subjects board at each site, Controls: SAGE, dbGaP Study Accession: phs000092.v1.p1","cases: approved, controls: waived"]
["may1","Biernacka J, Frye M, McElroy S","Mayo Clinic","USA",929.0,759.0,835.0,"Mayo Clinic Rochester, Minnesota; Lindner Center of HOPE/University of Cincinnati College of Medicine, Cincinnati Ohio; and the University of Minnesota, Minneapolis, Minnesota","approved"]
["mich","Boehnke M, Myers RM, Scott LJ","Pritzker Neuropsychiatric Disorders Research Consortium (U Michigan)","USA",481.0,399.0,436.0,"University of Michigan, Indiana University, Johns Hopkins University, the NIMH Intramural Research Program, Rush-Presbyterian Medical Center in Chicago, University of California at Irvine, University of California at San Diego, University of Chicago, University of Iowa, University of Pennsylvania, and Washington University in St. Louis","approved"]
["pf1e","Paciga S","Pfizer","USA",375.0,346.0,359.0,"Clincial trials (IDs NCT00141271, NCT00282464, NCT00483548), institutional review board and/or independent ethics committee at each center of recruitment","approved"]
["rom3","Grigoroiu-Serbanescu M, Nöthen MM","BOMA-Romania","Romania",233.0,198.0,214.0,"Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania","approved"]
["st2c","Sklar P, Smoller J; Stahl E (shared controls)","Systematic Treatment Enhancement Program for Bipolar Disorder (STEP2), MIGEN controls","USA",628.0,1219.0,828.0,"Cases: clinical trial (ID NCT000125580), institutional review board of each participating institution, Controls: dbGAP phs000294.v1.p1 (MIGEN controls)","cases: approved, controls:waived"]
["stp1","Sklar P, Smoller J","Systematic Treatment Enhancement Program for Bipolar Disorder (STEP1)","USA",920.0,973.0,945.0,"Cases: clinical trial (ID NCT000125580), institutional review board of each participating institution, Controls: dbGAP phs000294.v1.p1 (MIGEN controls)","cases: approved, controls:waived"]
["swa2","Landén M","Swedish Bipolar Collection I (SWEBIC I) Affy","Sweden",885.0,2252.0,1270.0,"Karolinska Institutet","approved"]
["swei","Landén M","Swedish Bipolar Collection I (SWEBIC I) Illumina","Sweden",1278.0,3669.0,1895.0,"Karolinska Institutet","approved"]
["top7","Andreassen O","Thematically Organized Psychosis (TOP)","Norway",416.0,350.0,380.0,"Norwegian Scientific-Ethical Committee and the Norwegian Data Protection Agency","approved"]
["top8","Andreassen O","Thematically Organized Psychosis (TOP), addtional samples on new platform","Norway",148.0,291.0,196.0,"Norwegian Scientific-Ethical Committee and the Norwegian Data Protection Agency","approved"]
["ucl2","Ophoff R","Dutch-UCLA","Holland",726.0,693.0,709.0,"UCLA and local ethics committees at psychiatric hospitals and institutions throughout the Netherlands","approved"]
["uclo","McQuillin A","University College London","UK",427.0,488.0,455.0,"Metropolitan Medical Research Ethics Committee","approved"]
["ume4","Adolfsson R","UMEA","Sweden",565.0,569.0,566.0,"Regional Ethical Review Board in Umeå","approved"]
["usc2","Pato C","ICCBD USC","USA",1293.0,1156.0,1220.0,"University of Southern California and site-specific Institutional Review Boards","approved"]
["wtcc","O'Donovan M, Di Florio A, Craddock N, Jones L, Jones I","Wellcome Trust Case-Control Consortium (WTCCC)","UK",1644.0,1641.0,1642.0,"Cases: Institutional Review Boards in Aberdeen, Birmingham, Cardiff, London, Newcastle, Controls: South East multicentre research ethics committee (1958 birth cohort), 05/Q0106/74 (UK Blood Services Controls)","approved"]
["butr*","Kirov G","Bulgarian trios*","Bulgaria",236.0,236.0,236.0,"Ethical Committees at several psychiatric hospitals in Bulgaria","approved"]
["uktr*","Kirov G","UK trios*","UK",130.0,130.0,130.0,"Relevant research ethics committees at lithium clinics in Wales and the South and Midlands of England","approved"]
["jea2","Li Q (Janssen); Esko T (shared controls)","Janssen","East. Europe",372.0,628.0,467.0,"Cases: Clinical trials (IDs: NCT00253162, NCT00257075, NCT00076115, NCT00299715, NCT00309699, and NCT00309686) conducted by Janssen Research & Development, LLC, institutional review board or human subjects board at each site, Controls: Ethics Review Committee on Human Research of the University of Tartu","approved"]
["kfo4","Schulze TG","PsyCourse","Germany",247.0,288.0,265.0,"Ethics Committees of the University Medical Center Goettingen (UMG Goettingen, Bad Zwischenahn, Eschwege, Asklepios Specialized Hospital Goettingen, Hildesheim, Lüneburg, Liebenburg, Osnabrück, Rotenburg, Tiefenbrunn, Wilhemshaven), Medical Faculty of the LMU Munich (Munich and Augsburg), Medical Faculty of the RU Bochum (Bochum), Medical Association Bremen (Bremen Ost), Medical University of Graz (Graz), Ulm University (Günzburg) and Medical Association Westfalen‐Lippe and Medical Faculty University of Münster (Münster) (PsyCourse Consortium)","approved"]
["tgco2","Kelsoe J","BIGs/TGEN","USA",1032.0,499.0,672.0,"Indiana University, John Hopkins University, the NIMH Intramural Research Program, Washington University at St. Louis, University of Pennsylvania, University of Chicago, Rush Medical School, University of Iowa, University of California, San Diego, University of California, San Francisco, and University of Michigan","approved"]
["bdtrs","Baune, BT; Dannlowski, U","Bipolar Depression Treatment Response Study","Germany",218.0,684.0,330.0,"University of Münster Human Ethics Committee, Münster, Germany","approved"]
["dutch","Ophoff R; Posthuma D, Lochner C, Franke B (shared controls)",null,"Holland",831.0,953.0,887.0,"UCLA and local ethics committees at psychiatric hospitals and institutions throughout the Netherlands, Controls: institutional review board of Vrije Universiteit Amsterdam, Health Research Ethics Committee at Stellenbosch University, Centrale Commissie Mensgebonden Onderzoek: CMO Regio Arnhem Nijmegen; 2008/163; ABR: NL23894.091.08, medical ethical committee of the VU University Medical Center","approved"]
["gawli","Gawlik M",null,"Germany",268.0,502.0,349.0,"Ethikkommisssion Universitätsklinik Würzburg","approved"]
["germ1","Reif, A","GUF-Bipolar","Germany",219.0,992.0,358.0,"Ethical committee of the Medical Faculty of the University of Würzburg","approved"]
["gpcw1","Pato, C","Genomic Psychiatry Consortium (GPC)","USA",447.0,2092.0,736.0,"University of Southern California and site-specific Institutional Review Boards","approved"]
["neuc1","Fullerton J, Mitchell PB, Schofield PR, Green MJ, Weickert CS, Weickert TW, The Australian Schizophrenia Research Bank","NeuRA-psych (including controls from The Australian Schizophrenia Research Bank)","Australia",215.0,750.0,334.0,"Cases & Controls: (BD Clinic Sample) Mood Disorder Unit, Prince of Wales Hospital in Sydney & UNSW Human Research Ethics Committee (HREC12623, HREC09394). (IGP sample) Human Research Ethics committees of UNSW (HC12384), St. Vincent's Hospital (HREC/10/SVH/9), and the South East Sydney and Illawarra Area Health Service (HREC 09/081). (BD high risk sample) UNSW Human Research Ethics Committee (HREC09097, HC14128, HC191009). Controls only: (CASSI sample) University of New South Wales (07/121 and 09/187), South Eastern Sydney and Illawarra Area Health Service (07-259) Human Research Ethics Committees and the Queen Elizabeth Hospital Ethics and Human Research Committee, Adelaide (2010188). (ASRB) Approval from each contributing site (HNE HREC 08/12/17/5.20, HREC/08/HNE/438, SSA/09/HNE/23).","approved"]
["spsp3","Serretti, A ; Ribases M (shared controls)",null,"Spain",153.0,2337.0,287.0,"Cases: Bipolar Disorders Unit, Hospital Clinic, University of Barcelona, Controls: Clinical Research Ethics Committee (CREC) of Hospital Universitari Vall d'Hebron","approved"]
["swed1","Landén M; Hillert J, Alfredsson L (shared controls)","GEMS  and EIMS","Sweden",2909.0,2844.0,2876.0,"Karolinska Institutet","approved"]
["ukwa1","Craddock N, Di Florio A, McQuillin A, McIntosh A; Breen G (shared controls)",null,"UK",2789.0,2372.0,2563.0,"UK National Health Service (NHS) Research Ethics Committee; West Midlands Multi-Centre Research Ethics Committee","approved"]
["usaw4","Perlis, R; Sklar, P; Smoller, J Goes, FS; Matthews C, Waldman I (shared controls)",null,"USA",2956.0,2930.0,2942.0,"Cases: Johns Hopkins University, Partners HealthCare System institutional review board, Controls: University of Florida Human Subjects Review Board, Emory University and University of Arizona Human Subjects Review Boards","approved"]
["usaw5","Perlis, R; Sklar, P; Smoller, J, Kelsoe J, Nievergelt C",null,"Canada/USA",1107.0,1316.0,1202.0,"Partners Institutional Review Board, The University Hospitals Institutional Review Board (IRB), University Hospitals, Cleveland, OH, Human Subjects Office/Institutional Research Board, University of Iowa, Office of Research Compliance – Indiana University, Office of Human Subjects Research Institutional Review Boards, Johns Hopkins University, Mayo Clinic Institutional Research Board, Human Research Protection Program (HRPP), University of Michigan, University of Pennsylvania, Institutional Research Board, BSD IRB Committee C, University of Chicago, Human Research Protections Program, University of California, San Diego","approved"]
["iPSYCH","Borglum A","iPSYCH","Denmark",1758.0,5937.0,2712.0,"Danish Data Protection Agency and the Scientific Ethics Committee in Denmark","approved"]
["deCODE","Stefansson H, Stefansson K","deCODE","Iceland",1972.0,192602.0,3904.0,"National Bioethics Committee of Iceland and the Icelandic Data Protection Authority","approved"]
["Estonian_Biobank","Milani L","Estonian Biobank","Estonia",407.0,17209.0,795.0,"Ethics Review Committee on Human Research of the University of Tartu","approved"]
["HUNT","Zwart JA","Nord-Trøndelag Health Study","Norway",905.0,41914.0,1771.0,"Data Inspectorate of Norway, the Health Directorate and the Regional Committee for Medical and Health Research Ethics","approved"]
["UK_Biobank","Breen G","UK Biobank","UK",1454.0,58113.0,2837.0,"North West Centre for Research Ethics Committee","approved"]
["bmrus","Rietschel M, Nöthen MM, Forstner AJ, Streit F, Babadjanova G","BOMA-Russia","Russia",522.0,460.0,489.0,"Russian State Medical University, Moscow","approved"]
["greek","Ferentinos P, Dikeos D, Patrinos G","ATLADIS (AThens Longitudinal Affective DIsorders Study)","Greece",186.0,87.0,118.0,"Research Ethics Committee of Attikon General Hospital","approved"]
["norgs","Andreassen O","Thematically Organized Psychosis (TOP), addtional samples on new platform","Norway",101.0,315.0,152.0,"Norwegian Scientific-Ethical Committee and the Norwegian Data Protection Agency","approved"]
["noroe","Andreassen O","Thematically Organized Psychosis (TOP), addtional samples on new platform","Norway",313.0,4367.0,584.0,"Norwegian Scientific-Ethical Committee and the Norwegian Data Protection Agency","approved"]
["graza","Reininghaus E, Bengesser S","BIPGEN","Austria",144.0,66.0,90.0,"Medical University of Graz","approved"]
["bmrom","Grigoroiu-Serbanescu M, Nöthen MM","BOMA-Romania II","Romania",225.0,121.0,157.0,"Alexandru Obregia Clinical Psychiatric Hospital, Bucharest, Romania","approved"]
["TOTAL",null,null,null,41917.0,371549.0,50981.0]
[]
["* Trio datasets. Neff half = half of the effective sample size 2*Ncases*Ncontrols/(Ncases + Ncontrols)"]
["^Pink color denotes that these cohorts were used for in-sample linkage disequilibrium calculations. "]

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["Supplementary Table 2. Genome-wide significant loci for bipolar disorder showing the most significant SNP from each genomic region (adapted from Mullins et al., Nat Genet, 2021)"]
["SNP","CHR","BP","P","OR (A1 allele)","SE","A1/A2","A1 freq in cases","A1 freq in controls","INFO","N cases","N controls","range.left.r2=0.1","range.right.r2=0.1","range.size.r2=0.1","range.left (3Mb window)","range.right (3Mb window)","Genes","N.genes.6.50kb","Locus name"]
["rs2126180",1.0,6.1105668E7,1.621E-9,0.94497,0.0094,"G/A",0.536,0.543,0.993,41917.0,371549.0,6.0890668E7,6.1129568E7,{"$f":"N3-M3","v":238900},6.1000001E7,6.4000001E7,"LINC01748,LOC101926964",2.0,"LINC01748"]
["rs10737496",1.0,1.63745389E8,7.172E-9,1.0557,0.0094,"C/T",0.467,0.444,0.992,41917.0,371549.0,1.63581389E8,1.63813589E8,232200,1.63000001E8,1.66000001E8,"-",0.0,"NUF2"]
["rs4619651",2.0,9.7416153E7,4.776E-11,1.06833,0.0101,"G/A",0.691,0.67,0.994,41917.0,371549.0,9.6396153E7,9.8357153E7,1961000,9.7000001E7,1.00000001E8,"KANSL3,FER1L5,LMAN2L,CNNM4,MIR3127,CNNM3-DT,CNNM3,ANKRD23",8.0,"LMAN2L"]
["rs17183814",2.0,1.66152389E8,2.678E-8,1.10838,0.0185,"G/A",0.933,0.924,0.978,41587.0,371396.0,1.66152389E8,1.66337389E8,185000,1.66000001E8,1.69000001E8,"SCN2A,CSRNP3",2.0,"SCN2A"]
["rs13417268",2.0,1.69481837E8,2.054E-8,1.06375,0.011,"C/G",0.768,0.758,0.99,41917.0,371549.0,1.69277837E8,1.69514837E8,237000,1.69000001E8,1.72000001E8,"CERS6,MIR4774",2.0,"CERS6"]
["rs2011302",2.0,1.93738336E8,4.254E-8,0.94847,0.0097,"T/A",0.621,0.623,0.99,41917.0,371549.0,1.93377336E8,1.94063336E8,686000,1.93000001E8,1.96000001E8,"-",0.0,"PCGEM1"]
["rs2719164",2.0,1.94437889E8,4.847E-8,1.05306,0.0095,"A/G",0.594,0.564,0.996,41917.0,371549.0,1.94017889E8,1.94749889E8,732000,1.94000001E8,1.97000001E8,"-",0.0,"intergenic"]
["rs9834970",3.0,3.685603E7,6.634E-19,0.92035,0.0093,"T/C",0.487,0.519,0.992,41917.0,371549.0,3.683413E7,3.726903E7,434900,3.6000001E7,3.9000001E7,"LINC02033,TRANK1",2.0,"TRANK1"]
["rs2336147",3.0,5.2626443E7,3.6149999999999997E-13,1.07004,0.0093,"T/C",0.504,0.498,0.999,41917.0,371549.0,5.2214443E7,5.3175443E7,961000,5.2000001E7,5.5000001E7,"NISCH,STAB1,NT5DC2,SMIM4,PBRM1,GNL3,SNORD136,SNORD19,SNORD19B,SNORD19C,SNORD69,GLT8D1,SPCS1,NEK4,ITIH1,ITIH3,ITIH4,ITIH4-AS1,MUSTN1,TMEM110-MUSTN1,STIMATE,MIR8064",22.0,"ITIH1"]
["rs115694474",3.0,7.0488788E7,2.345E-8,1.06844,0.0119,"T/A",0.812,0.799,0.993,41917.0,371549.0,7.0450188E7,7.0614788E7,164600,7.0000001E7,7.3000001E7,"-",0.0,"MDFIC2"]
["rs696366",3.0,1.0775706E8,4.464E-8,1.05295,0.0094,"C/A",0.558,0.55,0.986,41917.0,371549.0,1.077533E8,1.0794506E8,191760,1.07000001E8,1.10000001E8,"CD47,LINC01215,IFT57",3.0,"CD47"]
["rs112481526",4.0,1.23076007E8,1.8560000000000002E-9,0.93885,0.0105,"A/G",0.72,0.744,0.984,41917.0,371549.0,1.23000007E8,1.23559007E8,559000,1.23000001E8,1.26000001E8,"KIAA1109,ADAD1,IL2,IL21,IL21-AS1",5.0,"KIAA1109"]
["rs28565152",5.0,7542911.0,1.963E-9,0.9351,0.0112,"G/A",0.743,0.762,0.982,40159.0,365612.0,7493211.0,7614011.0,120800,7000001.0,1.0000001E7,"ADCY2",1.0,"ADCY2"]
["rs6865469",5.0,7.8849505E7,1.6500000000000002E-8,0.94346,0.0103,"G/T",0.711,0.726,0.996,41917.0,371549.0,7.8800105E7,7.8976505E7,176400,7.8000001E7,8.1000001E7,"HOMER1",1.0,"HOMER1"]
["rs6887473",5.0,8.0961069E7,8.814E-9,1.06216,0.0105,"G/A",0.727,0.739,0.992,41917.0,371549.0,8.0727069E7,8.0990869E7,263800,8.0000001E7,8.3000001E7,"SSBP2",1.0,"SSBP2"]
["rs10043984",5.0,1.37712121E8,3.7089999999999997E-8,0.94242,0.0108,"C/T",0.741,0.764,0.985,41917.0,371549.0,1.37673121E8,1.37837121E8,164000,1.37000001E8,1.40000001E8,"CDC25C,LOC100128966,FAM53C,KDM3B,REEP2",5.0,"KDM3B"]
["rs10866641",5.0,1.69289206E8,2.79E-11,1.0646,0.0094,"T/C",0.578,0.575,1.0,41917.0,371549.0,1.69172206E8,1.69348806E8,176600,1.69000001E8,1.72000001E8,"DOCK2,INSYN2B",2.0,"DOCK2"]
["rs13195402",6.0,2.6463575E7,5.751E-15,1.14614,0.0175,"G/T",0.923,0.919,0.985,41362.0,371275.0,2.5183575E7,2.9463575E7,4280000,2.6000001E7,2.9000001E7,"SCGN,HIST1H2AA,HIST1H2BA,HIST1H2APS1,SLC17A4,SLC17A1,SLC17A3,SLC17A2,TRIM38,HIST1H1A,HIST1H3A,HIST1H4A,HIST1H4B,HIST1H3B,HIST1H2AB,HIST1H2BB,HIST1H3C,HIST1H1C,LOC108783645,HFE,HIST1H4C,HIST1H1T,HIST1H2BC,HIST1H2AC,HIST1H1E,HIST1H2BD,HIST1H2BE,HIST1H4D,HIST1H3D,HIST1H2AD,HIST1H2BF,HIST1H4E,HIST1H2BG,HIST1H2AE,HIST1H3E,HIST1H1D,HIST1H4F,HIST1H4G,HIST1H3F,HIST1H2BH,HIST1H3G,HIST1H2BI,HIST1H4H,BTN3A2,BTN2A2,BTN3A1,BTN2A3P,BTN3A3,BTN2A1,LOC285819,BTN1A1,HCG11,HMGN4,LOC105374988,ABT1,ZNF322,GUSBP2,LINC00240,LOC100270746,HIST1H2BJ,HIST1H2AG,HIST1H2BK,HIST1H4I,HIST1H2AH,MIR3143,PRSS16,POM121L2,VN1R10P,ZNF204P,ZNF391,ZNF184,LINC01012,LOC100131289,HIST1H2BL,HIST1H2AI,HIST1H3H,HIST1H2AJ,HIST1H2BM,HIST1H4J,HIST1H4K,HIST1H2AK,HIST1H2BN,HIST1H2AL,HIST1H1B,HIST1H3I,HIST1H4L,HIST1H3J,HIST1H2AM,HIST1H2BO,OR2B2,OR2B6,OR1F12,ZNF165,ZSCAN12P1,ZSCAN16-AS1,ZSCAN16,ZKSCAN8,ZNF192P1,TOB2P1,ZSCAN9,ZKSCAN4,NKAPL,ZSCAN26,PGBD1,ZSCAN31,ZKSCAN3,ZSCAN12,ZSCAN23,GPX6,GPX5,ZBED9,LINC00533,LINC01623,HCG14,TRIM27,LINC01556,HCG15,ZNF311,LOC100129636,OR2W1,OR2B3,OR2J1,OR2J3,OR2J2,LOC101929006,OR14J1,OR5V1,OR12D3,OR12D2,OR12D1,OR11A1,OR10C1,OR2H1,MAS1L,LINC01015",135.0,"MHC"]
["rs1487445",6.0,9.8565211E7,1.484E-15,0.92849,0.0093,"C/T",0.502,0.513,1.0,41917.0,371549.0,9.8224211E7,9.8781211E7,557000,9.8000001E7,1.01000001E8,"-",0.0,"POU3F2"]
["rs4331993",6.0,1.52793572E8,1.979E-8,0.94677,0.0097,"T/A",0.634,0.618,1.0,41510.0,354340.0,1.52707072E8,1.52835772E8,128700,1.52000001E8,1.55000001E8,"SYNE1,SYNE1-AS1",2.0,"SYNE1"]
["rs10455979",6.0,1.6699526E8,4.218E-9,0.94592,0.0095,"C/G",0.512,0.5,0.988,41510.0,354340.0,1.6696996E8,1.6702326E8,53300,1.66000001E8,1.69000001E8,"RPS6KA2",1.0,"RPS6KA2"]
["rs12668848",7.0,2020995.0,1.9020000000000003E-9,1.05866,0.0095,"G/A",0.595,0.575,0.996,41917.0,371549.0,1861995.0,2344995.0,483000,2000001.0,5000001.0,"MAD1L1,MIR4655,SNORA114",3.0,"MAD1L1"]
["rs113779084",7.0,1.1871787E7,1.423E-13,0.92728,0.0102,"G/A",0.686,0.701,0.976,41917.0,371549.0,1.1854987E7,1.2023787E7,168800,1.1000001E7,1.4000001E7,"THSD7A",1.0,"THSD7A"]
["rs6954854",7.0,2.1492589E7,5.936E-10,1.06003,0.0094,"G/A",0.436,0.425,0.996,41917.0,371549.0,2.1451289E7,2.1556989E7,105700,2.1000001E7,2.4000001E7,"SP4,MIR1183,DNAH11",3.0,"SP4"]
["rs12672003",7.0,2.4647222E7,2.718E-9,0.91211,0.0155,"A/G",0.883,0.887,0.996,39352.0,161651.0,2.4499222E7,2.4845222E7,346000,2.4000001E7,2.7000001E7,"MPP6,GSDME,OSBPL3",3.0,"MPP6"]
["rs11764361",7.0,1.05043229E8,3.471E-9,1.06343,0.0104,"A/G",0.671,0.668,0.905,41917.0,371549.0,1.04455229E8,1.05048159E8,592930,1.05000001E8,1.08000001E8,"SRPK2,PUS7",2.0,"SRPK2"]
["rs6946056",7.0,1.31870597E8,3.655E-8,0.94819,0.0097,"A/C",0.382,0.377,0.982,41917.0,371549.0,1.31859097E8,1.31929697E8,70600,1.31000001E8,1.34000001E8,"PLXNA4,LOC101928807",2.0,"PLXNA4"]
["rs10255167",7.0,1.40676153E8,1.599E-8,0.93576,0.0118,"G/A",0.215,0.222,0.993,39945.0,178947.0,1.40244153E8,1.40807153E8,563000,1.40000001E8,1.43000001E8,"BRAF,MRPS33,TMEM178B",3.0,"MRPS33"]
["rs62489493",8.0,9763581.0,2.6419999999999998E-11,0.91421,0.0135,"C/G",0.856,0.872,0.986,41917.0,371549.0,8313581.0,1.1453581E7,3140000,9000001.0,1.2000001E7,"TNKS,LINC00599,MIR124-1",3.0,"miR124-1"]
["rs3088186",8.0,1.0226355E7,2.084E-8,0.94488,0.0101,"C/T",0.686,0.713,0.994,41917.0,371549.0,8096355.0,1.1826355E7,3730000,1.0000001E7,1.3000001E7,"MSRA",1.0,"MSRA"]
["rs2953928",8.0,3.4152492E7,6.249E-9,0.89039,0.02,"G/A",0.941,0.933,1.0,41362.0,371275.0,3.3405492E7,3.5162492E7,1757000,3.4000001E7,3.7000001E7,"-",0.0,"RP1-84O15.2(lincRNA)"]
["rs6992333",8.0,1.44993377E8,1.621E-9,0.94158,0.01,"A/G",0.568,0.59,0.967,39945.0,178947.0,1.44973177E8,1.45099377E8,126200,1.44000001E8,1.47000001E8,"EPPK1,PLEC,MIR661,PARP10,GRINA,SPATC1,OPLAH,MIR6846,EXOSC4,MIR6847",10.0,"PLEC"]
["rs10973201",9.0,3.7090538E7,2.449E-8,0.90846,0.0172,"T/C",0.882,0.89,0.799,39538.0,161738.0,3.7003738E7,3.7411538E7,407800,3.7000001E7,4.0000001E7,"PAX5,EBLN3P,ZCCHC7,GRHPR",4.0,"ZCCH7"]
["rs62581014",9.0,1.4106649E8,2.7740000000000002E-8,0.93688,0.0117,"C/T",0.62,0.634,0.694,39543.0,312463.0,1.4099209E8,1.4107689E8,84800,1.41000001E8,1.44000001E8,"CACNA1B,TUBBP5,LOC101928932",3.0,"TUBBP5"]
["rs1998820",10.0,1.8751103E7,4.1E-8,1.0873,0.0152,"T/A",0.899,0.886,0.995,41917.0,371549.0,1.8602103E7,1.8782803E7,180700,1.8000001E7,2.1000001E7,"CACNB2",1.0,"CACNB2"]
["rs10994415",10.0,6.2322034E7,1.1399999999999999E-11,0.88861,0.0174,"T/C",0.912,0.918,0.999,39759.0,178860.0,6.2048034E7,6.2384334E7,336300,6.2000001E7,6.5000001E7,"ANK3",1.0,"ANK3"]
["rs10761661",10.0,6.4525135E7,4.645E-8,0.95009,0.0094,"C/T",0.54,0.528,0.995,41917.0,371549.0,6.4387135E7,6.4630135E7,243000,6.4000001E7,6.7000001E7,"ZNF365,ADO,EGR2",3.0,"ADO"]
["rs2273738",10.0,1.11648659E8,1.627E-11,0.91238,0.0136,"C/T",0.847,0.865,0.936,41917.0,371549.0,1.11530659E8,1.12015659E8,485000,1.11000001E8,1.14000001E8,"XPNPEP1,ADD3-AS1,ADD3",3.0,"ADD3"]
["rs174592",11.0,6.1618608E7,9.923999999999999E-14,0.93053,0.0097,"A/G",0.619,0.605,0.987,41917.0,371549.0,6.1521308E7,6.1658808E7,137500,6.1000001E7,6.4000001E7,"DAGLA,MYRF,DKFZP434K028,TMEM258,MIR611,FEN1,FADS1,MIR1908,FADS2,FADS3,MIR6746,RAB3IL1",12.0,"FADS2"]
["rs4672",11.0,6.4009879E7,3.42E-9,0.9033,0.0172,"G/A",0.916,0.917,0.98,40997.0,370576.0,6.3810879E7,6.4176879E7,366000,6.4000001E7,6.7000001E7,"MACROD1,STIP1,FERMT3,TRPT1,NUDT22,DNAJC4,VEGFB,FKBP2,PPP1R14B,LOC105369340,PLCB3,BAD,GPR137,KCNK4,KCNK4-TEX40",15.0,"FKBP2"]
["rs475805",11.0,6.5848738E7,1.9910000000000003E-9,0.9352,0.0112,"G/A",0.228,0.233,0.994,41510.0,354340.0,6.5785738E7,6.6060738E7,275000,6.5000001E7,6.8000001E7,"EIF1AD,BANF1,CST6,CATSPER1,GAL3ST3,SF3B2,SNORD13F,PACS1,KLC2,RAB1B,CNIH2,YIF1A,TMEM151A,CD248",14.0,"PACS1"]
["rs678397",11.0,6.6324583E7,5.462E-9,1.05601,0.0093,"T/C",0.467,0.457,0.998,41917.0,371549.0,6.6064583E7,6.6832583E7,768000,6.6000001E7,6.9000001E7,"NPAS4,MRPL11,PELI3,LOC101928069,DPP3,BBS1,ZDHHC24,ACTN3,CTSF,CCDC87,CCS,RBM14,RBM14-RBM4,RBM4,RBM4B,SPTBN2,C11orf80",17.0,"PC"]
["rs12575685",11.0,7.0517927E7,1.243E-10,0.93688,0.0101,"G/A",0.674,0.673,0.964,41917.0,371549.0,7.0492827E7,7.0630927E7,138100,7.0000001E7,7.3000001E7,"SHANK2,SHANK2-AS1",2.0,"SHANK2"]
["rs12289486",11.0,7.9092527E7,3.297E-8,0.92072,0.0149,"C/T",0.888,0.885,0.996,41917.0,371549.0,7.9057127E7,7.9191427E7,134300,7.9000001E7,8.2000001E7,"TENM4,MIR708,MIR5579",3.0,"ODZ4"]
["rs11062170",12.0,2348844.0,1.869E-15,0.92506,0.0098,"G/C",0.652,0.667,1.0,41917.0,371549.0,2274044.0,2440444.0,166400,2000001.0,5000001.0,"CACNA1C,CACNA1C-AS4,CACNA1C-IT3",3.0,"CACNA1C"]
["rs35306827",13.0,1.13869045E8,3.5550000000000002E-9,1.06812,0.0112,"G/A",0.773,0.775,0.986,41917.0,371549.0,1.13800645E8,1.13989045E8,188400,1.13000001E8,1.16000001E8,"F7,F10,F10-AS1,PROZ,PCID2,CUL4A,MIR8075,LAMP1",8.0,"CUL4A"]
["rs2693698",14.0,9.9719219E7,1.961E-8,0.94838,0.0094,"A/G",0.44,0.449,0.985,41917.0,371549.0,9.9667219E7,9.9733919E7,66700,9.9000001E7,1.02000001E8,"BCL11B",1.0,"BCL11B"]
["rs35958438",15.0,3.8973793E7,3.83E-8,1.06631,0.0117,"G/A",0.782,0.772,0.992,39945.0,178947.0,3.8927093E7,3.9007193E7,80100,3.8000001E7,4.1000001E7,"C15orf53",1.0,"C15orf53"]
["rs4447398",15.0,4.2904904E7,2.613E-9,1.08567,0.0138,"A/C",0.137,0.131,0.984,41917.0,371549.0,4.2439904E7,4.3377904E7,938000,4.2000001E7,4.5000001E7,"SNAP23,LRRC57,HAUS2,STARD9",4.0,"STARD9"]
["rs62011709",15.0,8.3531774E7,1.433E-8,1.06418,0.011,"T/A",0.771,0.747,0.998,41917.0,371549.0,8.2511774E7,8.4027774E7,1516000,8.3000001E7,8.6000001E7,"FSD2,WHAMM,HOMER2,RAMAC,C15orf40,BTBD1,MIR4515,TM6SF1,HDGFL3,BNC1",10.0,"HOMER2"]
["rs748455",15.0,8.5149575E7,5.011E-11,1.06983,0.0103,"T/C",0.714,0.719,0.997,41917.0,371549.0,8.4641575E7,8.5392575E7,751000,8.5000001E7,8.8000001E7,"ADAMTSL3,EFL1P1,UBE2Q2L,LOC440300,GOLGA2P7,LOC642423,GOLGA6L4,LOC103171574,LOC102724034,DNM1P41,GOLGA6L5P,UBE2Q2P1,LINC00933,ZSCAN2,SCAND2P,WDR73,NMB,SEC11A,ZNF592,ALPK3,SLC28A1",21.0,"ZNF592"]
["rs4702",15.0,9.142656E7,3.518E-9,1.05897,0.0097,"G/A",0.457,0.446,0.951,40997.0,370576.0,9.141656E7,9.143152E7,14960,9.1000001E7,9.4000001E7,"FURIN,FES,MAN2A2,UNC45A,HDDC3",5.0,"FURIN"]
["rs28455634",16.0,9230816.0,2.626E-10,1.06481,0.0099,"G/A",0.626,0.62,0.937,41917.0,371549.0,9130816.0,9238386.0,107570,9000001.0,1.2000001E7,"C16orf72",1.0,"C16orf72"]
["rs7199910",16.0,9926348.0,1.663E-8,0.94582,0.0099,"T/G",0.65,0.688,0.99,41917.0,371549.0,9800348.0,1.0047348E7,247000,9000001.0,1.2000001E7,"GRIN2A",1.0,"GRIN2A"]
["rs12932628",16.0,8.9632725E7,6.711E-9,0.94459,0.0098,"G/T",0.523,0.513,0.925,41510.0,354340.0,8.9385725E7,8.9656625E7,270900,8.9000001E7,9.2000001E7,"SPG7,RPL13,SNORD68,CPNE7,DPEP1",5.0,"RPL13"]
["rs4790841",17.0,1835482.0,3.1409999999999995E-8,0.92969,0.0132,"C/T",0.834,0.849,0.937,40997.0,370576.0,1816782.0,1866882.0,50100,1000001.0,4000001.0,"RPA1,RTN4RL1",2.0,"RTN4RL1"]
["rs11870683",17.0,3.8129841E7,2.786E-8,1.05897,0.0103,"T/A",0.657,0.65,0.975,39945.0,178947.0,3.7830841E7,3.8218841E7,388000,3.8000001E7,4.1000001E7,"ORMDL3,LRRC3C,GSDMA,PSMD3,CSF3,MED24,MIR6884,SNORD124,THRA,NR1D1",10.0,"ERBB2"]
["rs61554907",17.0,3.8220432E7,1.6360000000000002E-8,0.91686,0.0154,"G/T",0.887,0.876,0.944,40997.0,370576.0,3.7949432E7,3.8481432E7,532000,3.8000001E7,4.1000001E7,"CSF3,MED24,MIR6884,SNORD124,THRA,NR1D1",6.0,"ERBB2"]
["rs228768",17.0,4.2191893E7,2.827E-10,1.06652,0.0102,"G/T",0.322,0.294,0.976,41917.0,371549.0,4.2090893E7,4.2333893E7,243000,4.2000001E7,4.5000001E7,"LSM12,G6PC3,HDAC5,LOC105371789,C17orf53,ASB16,ASB16-AS1,TMUB2,ATXN7L3,UBTF,MIR6782",11.0,"HDAC5"]
["rs67712855",20.0,4.3682551E7,4.2209999999999996E-11,1.07004,0.0103,"T/G",0.705,0.687,0.997,41510.0,354340.0,4.3592251E7,4.3772251E7,180000,4.3000001E7,4.6000001E7,"PABPC1L,TOMM34,STK4-AS1,STK4,KCNS1,WFDC5,WFDC12",7.0,"WFDC12"]
["rs6032110",20.0,4.3944323E7,1.01E-9,1.05908,0.0094,"A/G",0.537,0.512,0.985,41917.0,371549.0,4.3750323E7,4.3970423E7,220100,4.3000001E7,4.6000001E7,"SLPI,MATN4,RBPJL,SDC4,SYS1,SYS1-DBNDD2",6.0,"STK4"]
["rs237460",20.0,4.8033127E7,4.253E-9,0.9462,0.0094,"C/T",0.563,0.588,1.0,41917.0,371549.0,4.8007227E7,4.8130327E7,123100,4.8000001E7,5.1000001E7,"KCNB1",1.0,"KCNB1"]
["rs13044225",20.0,6.0865815E7,8.498000000000001E-9,0.94677,0.0095,"A/G",0.528,0.56,0.985,41510.0,354340.0,6.0781515E7,6.0886615E7,105100,6.0000001E7,6.3000001E7,"SS18L1,MTG2,HRH3,OSBPL2,ADRM1,LAMA5,MIR4758,LAMA5-AS1",8.0,"OSBPL2"]
["rs5758064",22.0,4.1153879E7,2.011E-8,1.0538,0.0093,"T/C",0.524,0.523,0.996,41917.0,371549.0,4.0876879E7,4.1587879E7,711000,4.1000001E7,4.4000001E7,"MRTFA,MCHR1,SLC25A17,MIR4766,ST13,XPNPEP3,DNAJB7,RBX1",8.0,"SLC25A17"]
[]
["SNP, single nucleotide polymorphism; CHR, chromosome; BP,  GRCh37 base-pair position; P, two-sided uncorrected p-value from an inverse variance-weighted fixed effects model meta-analysis; OR, odds ratio;  SE, standard error; freq, frequency; INFO, imputation information score (average weighted by effective sample size per cohort);"]
["range.left.r2=0.1, range.right.r2=0.1, left and right margins and span of region defined based on linkage disequilibrium r2 0.1;"]
["range.left(3Mb window), range.right(3Mb window), left and right margins of predefined 3Mb-long regions from Weissbrod et al. 2020 (PMID: 33199916) that include each locus;"]
["Genes, list of genes in the region based on linkage disequilibrium r2 0.6 (±50 kb); N.genes.6.50kb, number of genes in the region based on linkage disequilibrium r2 0.6 (±50 kb);"]
["Locus name, assigned locus name of each one of the 64 loci to be fine-mapped based as published in Mullins et al. 2021 (PMID: 34002096);"]

{"sheet":"Table S3","index":3,"n_rows":73,"n_cols":13,"rows_kept":73,"cut":false,"hidden":false,"merged":[[0,0,0,9]]}
["Supplementary Table S3. Results of conditional analysis in each BD risk locus using GCTA-COJO and GWAS summary statistics."]
["Index SNP","CHR","Index SNP BP","Index SNP P value ","BP left boundary","BP right boundary","N signals","2nd SNP BP","2nd SNP ","2nd SNP P value","3rd SNP BP","3rd SNP ","3rd SNP P value"]
["rs2126180",1.0,6.1105668E7,1.621E-9,6.0890668E7,6.1129568E7,1.0,6.0949956E7,"rs72673445",0.00452516]
["rs10737496",1.0,1.63745389E8,7.172E-9,1.63581389E8,1.63813589E8,1.0,1.6360767E8,"rs191191494",0.00801642]
["rs4619651",2.0,9.7416153E7,4.776E-11,9.6396153E7,9.8357153E7,1.0,9.6914636E7,"rs11551400",7.018E-6]
["rs17183814",2.0,1.66152389E8,2.678E-8,1.66152389E8,1.66337389E8,1.0,1.66334559E8,"rs376286377",0.0352826]
["rs13417268",2.0,1.69481837E8,2.054E-8,1.69277837E8,1.69514837E8,1.0,1.69495399E8,"rs34417335",3.16925E-4]
["rs2011302",2.0,1.93738336E8,4.254E-8,1.93377336E8,1.94063336E8,1.0,1.935121E8,"rs74556083",0.00194046]
["rs2719164",2.0,1.94437889E8,4.847E-8,1.94017889E8,1.94749889E8,1.0,1.94518833E8,"rs62184849",0.00471506]
["rs9834970",3.0,3.685603E7,6.634E-19,3.683413E7,3.726903E7,1.0,3.6948417E7,"rs4678914",0.0156908]
["rs2336147",3.0,5.2626443E7,3.6149999999999997E-13,5.2214443E7,5.3175443E7,1.0,5.3004465E7,"rs62253650",0.0016491]
["rs115694474",3.0,7.0488788E7,2.345E-8,7.0450188E7,7.0614788E7,1.0,7.048696E7,"rs62255201",0.00696227]
["rs696366",3.0,1.0775706E8,4.464E-8,1.077533E8,1.0794506E8,1.0,1.07840137E8,"rs75380735",4.1582E-4]
["rs112481526",4.0,1.23076007E8,1.8560000000000002E-9,1.23000007E8,1.23559007E8,1.0,1.23122856E8,"rs77087420",0.00588944]
["rs28565152",5.0,7542911.0,1.963E-9,7493211.0,7614011.0,1.0,7584031.0,"rs11134244",0.053465]
["rs6865469",5.0,7.8849505E7,1.6500000000000002E-8,7.8800105E7,7.8976505E7,1.0,7.8813826E7,"rs66766617",0.00322815]
["rs6887473",5.0,8.0961069E7,8.814E-9,8.0727069E7,8.0990869E7,1.0,8.0739476E7,"rs13160388",0.00861547]
["rs10043984",5.0,1.37712121E8,3.7089999999999997E-8,1.37673121E8,1.37837121E8,1.0,1.37693329E8,"rs142394181",0.00111451]
["rs10866641",5.0,1.69289206E8,2.79E-11,1.69172206E8,1.69348806E8,1.0,1.6932762E8,"rs261056",1.49545E-4]
["rs13195402",6.0,2.6463575E7,5.751E-15,2.5183575E7,2.9463575E7,1.0,2.8677514E7,"rs61657599",5.48E-6]
["rs1487445",6.0,9.8565211E7,1.484E-15,9.8224211E7,9.8781211E7,1.0,9.8307456E7,"rs117516868",0.00145138]
["rs4331993",6.0,1.52793572E8,1.979E-8,1.52707072E8,1.52835772E8,1.0,1.52761079E8,"rs17463277",0.0122164]
["rs10455979",6.0,1.6699526E8,4.218E-9,1.6696996E8,1.6702326E8,1.0,1.66971926E8,"rs9355584",0.0012729]
["rs12668848",7.0,2020995.0,1.9020000000000003E-9,1861995.0,2344995.0,1.0,2111636.0,"rs10950536",0.00486616]
["rs113779084",7.0,1.1871787E7,1.423E-13,1.1854987E7,1.2023787E7,1.0,1.1863689E7,"rs560621662",0.0149463]
["rs6954854",7.0,2.1492589E7,5.936E-10,2.1451289E7,2.1556989E7,1.0,2.1539263E7,"rs62441762",0.00177521]
["rs12672003",7.0,2.4647222E7,2.718E-9,2.4499222E7,2.4845222E7,1.0,2.4835787E7,"rs2106760",0.0290141]
["rs11764361",7.0,1.05043229E8,3.471E-9,1.04455229E8,1.05048159E8,1.0,1.04651557E8,"rs74365863",0.00231996]
["rs6946056",7.0,1.31870597E8,3.655E-8,1.31859097E8,1.31929697E8,1.0,1.31859162E8,"rs80172977",0.00599699]
["rs10255167",7.0,1.40676153E8,1.599E-8,1.40244153E8,1.40807153E8,1.0,1.4049346E8,"rs146653274",0.00774229]
["rs62489493",8.0,9763581.0,2.6419999999999998E-11,8313581.0,1.1453581E7,1.0,1.0226355E7,"rs3088186",1.29377E-4]
["rs3088186",8.0,1.0226355E7,2.084E-8,8096355.0,1.1826355E7,2.0,9763581.0,"rs62489493",2.83205E-7,1.1526986E7,"rs12675779",1.16269E-4]
["rs2953928",8.0,3.4152492E7,6.25E-9,3.3405492E7,3.5162492E7,2.0,3.4882482E7,"rs6989491",4.06454E-6,3.4430573E7,"rs146603236",5.48681E-5]
["rs6992333",8.0,1.44993377E8,1.621E-9,1.44973177E8,1.45099377E8,1.0,1.44998514E8,"rs75586449",0.0151074]
["rs10973201",9.0,3.7090538E7,2.449E-8,3.7003738E7,3.7411538E7,1.0,3.7166189E7,"rs62535709",0.00421647]
["rs62581014",9.0,1.4106649E8,2.7740000000000002E-8,1.4099209E8,1.4107689E8,1.0,1.41034913E8,"rs62579522",0.00831003]
["rs1998820",10.0,1.8751103E7,4.1E-8,1.8602103E7,1.8782803E7,1.0,1.862163E7,"rs17610275",3.03488E-4]
["rs10994415",10.0,6.2322034E7,1.1399999999999999E-11,6.2048034E7,6.2384334E7,1.0,6.2111617E7,"rs1361486",0.00116049]
["rs10761661",10.0,6.4525135E7,4.645E-8,6.4387135E7,6.4630135E7,1.0,6.4445025E7,"rs74488156",9.14795E-4]
["rs2273738",10.0,1.11648659E8,1.627E-11,1.11530659E8,1.12015659E8,1.0,1.11897648E8,"rs76025286",0.00501026]
["rs174592",11.0,6.1618608E7,9.923999999999999E-14,6.1521308E7,6.1658808E7,1.0,6.1528306E7,"rs198470",0.00159709]
["rs4672",11.0,6.4009879E7,3.42E-9,6.3810879E7,6.4176879E7,1.0,6.3951236E7,"rs77171471",0.00106478]
["rs475805",11.0,6.5848738E7,1.9910000000000003E-9,6.5785738E7,6.6060738E7,1.0,6.5989041E7,"rs187649293",0.0102967]
["rs678397",11.0,6.6324583E7,5.462E-9,6.6064583E7,6.6832583E7,1.0,6.6092567E7,"rs76878669",0.00293908]
["rs12575685",11.0,7.0517927E7,1.243E-10,7.0492827E7,7.0630927E7,1.0,7.052915E7,"rs10899375",5.89406E-4]
["rs12289486",11.0,7.9092527E7,3.297E-8,7.9057127E7,7.9191427E7,1.0,7.9188775E7,"rs146458208",0.00862892]
["rs11062170",12.0,2348844.0,1.869E-15,2274044.0,2440444.0,1.0,2420244.0,"rs10848645",0.0158]
["rs35306827",13.0,1.13869045E8,3.5550000000000002E-9,1.13800645E8,1.13989045E8,1.0,1.1397988E8,"rs55866528",0.00765]
["rs2693698",14.0,9.9719219E7,1.961E-8,9.9667219E7,9.9733919E7,1.0,9.9688898E7,"rs2793323",0.00106361]
["rs35958438",15.0,3.8973793E7,3.83E-8,3.8927093E7,3.9007193E7,1.0,3.8931396E7,"rs12439571",0.0499742]
["rs4447398",15.0,4.2904904E7,2.613E-9,4.2439904E7,4.3377904E7,1.0,4.2924234E7,"rs116936632",0.00200943]
["rs62011709",15.0,8.3531774E7,1.433E-8,8.2511774E7,8.4027774E7,1.0,8.3733002E7,"rs76326109",8.13039E-4]
["rs748455",15.0,8.5149575E7,5.011E-11,8.4641575E7,8.5392575E7,1.0,8.4952645E7,"rs68184996",0.00310944]
["rs4702",15.0,9.142656E7,3.518E-9,9.141656E7,9.143152E7,1.0,9.1427481E7,"rs112565281",0.0510594]
["rs28455634",16.0,9230816.0,2.626E-10,9130816.0,9238386.0,1.0,9134819.0,"rs112549699",0.00831244]
["rs7199910",16.0,9926348.0,1.663E-8,9800348.0,1.0047348E7,1.0,9846516.0,"rs76047272",0.00140579]
["rs12932628",16.0,8.9632725E7,6.711E-9,8.9385725E7,8.9656625E7,1.0,8.9403085E7,"rs56781321",0.00458986]
["rs4790841",17.0,1835482.0,3.1409999999999995E-8,1816782.0,1866882.0,1.0,1824542.0,"rs80050626",0.00963732]
["rs11870683",17.0,3.8129841E7,2.786E-8,3.7830841E7,3.8218841E7,1.0,3.8217136E7,"rs34867153",5.42712E-5]
["rs61554907",17.0,3.8220432E7,1.6360000000000002E-8,3.7949432E7,3.8481432E7,1.0,3.8129841E7,"rs11870683",2.05072E-5]
["rs228768",17.0,4.2191893E7,2.827E-10,4.2090893E7,4.2333893E7,1.0,4.2111443E7,"rs111767734",6.55476E-4]
["rs67712855",20.0,4.3682551E7,4.2209999999999996E-11,4.3592251E7,4.3772251E7,1.0,4.3766067E7,"rs2143943",5.74309E-5]
["rs6032110",20.0,4.3944323E7,1.01E-9,4.3750323E7,4.3970423E7,1.0,4.3963739E7,"rs12053610",0.0039]
["rs237460",20.0,4.8033127E7,4.253E-9,4.8007227E7,4.8130327E7,1.0,4.8066889E7,"rs118085064",7.97684E-4]
["rs13044225",20.0,6.0865815E7,8.498000000000001E-9,6.0781515E7,6.0886615E7,1.0,6.0864068E7,"rs3746656",0.00413689]
["rs5758064",22.0,4.1153879E7,2.011E-8,4.0876879E7,4.1587879E7,1.0,4.108895E7,"rs140427371",0.00555662]
[]
["Index SNP, Most significant SNP in the locus from the GWAS; Index SNP P value, P value of the index SNP from the GWAS;  "]
["BP Left, Region lower bound based on linkage disequilibrium r2 0.1; BP Right, Region higher bound based on linkage disequilibrium r2 0.1;"]
["N signals, number of independent association signals in the locus, defined as the presence of a SNP with conditional P < 5E-06 "]
["2nd SNP, Most significant SNP after conditioning on the index SNP; 2nd SNP P value, P value of the 2nd SNP after conditioning on the index SNP"]
["3rd SNP, Most significant SNP after conditioning on the index SNP and 2nd SNP; 3rd SNP P value, P value of the 3rd SNP after conditioning on the index SNP and 2nd SNP"]
["All base pair positions are on GRCh37."]

{"sheet":"Table S4","index":4,"n_rows":70,"n_cols":35,"rows_kept":70,"cut":false,"hidden":false,"merged":[[0,0,0,18]]}
["Supplementary Table 4. Number of SNPs (PIP >0.95) per GWS locus across fine-mapping methods, LD reference panels and fine-mapping windows."]
["Index SNP","CHR","BP","FINEMAP. UKB.GWS locus window","SuSiE.UKB.GWS locus window","PolyFun+FINEMAP.UKB.GWS locus window","PolyFun+SuSiE.UKB.GWS locus window","FINEMAP.UKB.3Mb window","SuSiE.UKB.3Mb window","PolyFun+FINEMAP.UKB.3Mb window","PolyFun+SuSiE.UKB.3Mb window","FINEMAP.HRC.GWS locus window","SuSiE.HRC.GWS locus window","PolyFun+FINEMAP.HRC.GWS locus window","PolyFun+SuSiE.HRC.GWS locus window","FINEMAP.HRC.3Mb window","SuSiE.HRC.3Mb window","PolyFun+FINEMAP.HRC.3Mb window","PolyFun+SuSiE.HRC.3Mb window","FINEMAP.InSampleLD.GWS locus window","SuSiE.InSampleLD.GWS locus window","PolyFun+FINEMAP.InSampleLD.GWS locus window","PolyFun+SuSiE.InSampleLD.GWS locus window","FINEMAP.InSampleLD.3Mb window","SuSiE.InSampleLD.3Mb window","PolyFun+FINEMAP.InSampleLD.3Mb window","PolyFun+SuSiE.InSampleLD.3Mb window","FINEMAP.NoLD.GWS locus window","SuSiE.NoLD.GWS locus window","PolyFun+FINEMAP.NoLD.GWS locus window","PolyFun+SuSiE.NoLD.GWS locus window","FINEMAP.NoLD.3Mb window","SuSiE.NoLD.3Mb window","PolyFun+FINEMAP.NoLD.3Mb window","PolyFun+SuSiE.NoLD.3Mb window"]
["rs2126180",1.0,6.1105668E7]
["rs10737496",1.0,1.63745389E8]
["rs4619651",2.0,9.7416153E7]
["rs17183814",2.0,1.66152389E8]
["rs13417268",2.0,1.69481837E8]
["rs2011302",2.0,1.93738336E8,{"$nulls":6},2.0]
["rs2719164",2.0,1.94437889E8,2.0,null,3.0]
["rs9834970",3.0,3.685603E7,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0]
["rs2336147",3.0,5.2626443E7]
["rs115694474",3.0,7.0488788E7,2.0,null,2.0]
["rs696366",3.0,1.0775706E8,{"$nulls":18},2.0]
["rs112481526",4.0,1.23076007E8]
["rs28565152",5.0,7542911.0]
["rs6865469",5.0,7.8849505E7,{"$nulls":4},1.0]
["rs6887473",5.0,8.0961069E7,{"$nulls":5},1.0,null,1.0,{"$nulls":5},1.0,null,1.0,{"$nulls":4},1.0,1.0,null,1.0]
["rs10043984",5.0,1.37712121E8]
["rs10866641",5.0,1.69289206E8]
["rs13195402",6.0,2.6463575E7]
["rs1487445",6.0,9.8565211E7]
["rs4331993",6.0,1.52793572E8]
["rs10455979",6.0,1.6699526E8]
["rs12668848",7.0,2020995.0]
["rs113779084",7.0,1.1871787E7,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0,1.0]
["rs6954854",7.0,2.1492589E7]
["rs12672003",7.0,2.4647222E7]
["rs11764361",7.0,1.05043229E8]
["rs6946056",7.0,1.31870597E8]
["rs10255167",7.0,1.40676153E8]
["rs62489493",8.0,9763581.0]
["rs3088186",8.0,1.0226355E7]
["rs2953928",8.0,3.4152492E7]
["rs6992333",8.0,1.44993377E8]
["rs10973201",9.0,3.7090538E7]
["rs62581014",9.0,1.4106649E8]
["rs1998820",10.0,1.8751103E7]
["rs10994415",10.0,6.2322034E7]
["rs10761661",10.0,6.4525135E7]
["rs2273738",10.0,1.11648659E8]
["rs174592",11.0,6.1618608E7]
["rs4672",11.0,6.4009879E7,1.0,null,1.0,1.0,1.0,1.0,1.0,1.0,{"$nulls":4},1.0,1.0,1.0,1.0,{"$nulls":4},1.0,1.0,1.0,1.0]
["rs475805",11.0,6.5848738E7]
["rs678397",11.0,6.6324583E7]
["rs12575685",11.0,7.0517927E7,{"$nulls":17},1.0]
["rs12289486",11.0,7.9092527E7]
["rs11062170",12.0,2348844.0]
["rs35306827",13.0,1.13869045E8]
["rs2693698",14.0,9.9719219E7]
["rs35958438",15.0,3.8973793E7]
["rs4447398",15.0,4.2904904E7]
["rs62011709",15.0,8.3531774E7]
["rs748455",15.0,8.5149575E7]
["rs4702",15.0,9.142656E7]
["rs28455634",16.0,9230816.0,null,null,null,1.0,1.0,null,1.0,{"$nulls":4},1.0,1.0,null,1.0,{"$nulls":4},1.0,1.0,null,1.0,null,null,null,1.0,1.0]
["rs7199910",16.0,9926348.0,{"$nulls":4},1.0,null,1.0,{"$nulls":5},1.0,null,1.0,{"$nulls":5},1.0,null,1.0]
["rs12932628",16.0,8.9632725E7]
["rs4790841",17.0,1835482.0]
["rs11870683",17.0,3.8129841E7,{"$nulls":7},1.0,{"$nulls":15},1.0]
["rs61554907",17.0,3.8220432E7,null,null,1.0,1.0,null,null,null,1.0,null,null,null,1.0,null,null,null,1.0,null,null,null,1.0,null,null,null,1.0]
["rs228768",17.0,4.2191893E7]
["rs67712855",20.0,4.3682551E7]
["rs6032110",20.0,4.3944323E7]
["rs237460",20.0,4.8033127E7]
["rs13044225",20.0,6.0865815E7]
["rs5758064",22.0,4.1153879E7]
[]
["SNP, single nucleotide polymorphism; CHR, chromosome; BP,  GRCh37 base-pair position; PIP, posterior inclusion probability; "]
["GWS locus window, the region defined by the positions of the 3'-most and 5'-most SNPs, requiring an LD r2 greater than 0.1 with the top lead SNP within a 3Mb range;"]
["3Mb window, a 3Mb-long region which includes the top lead SNP of the GWS locus."]

{"sheet":"Table S5","index":5,"n_rows":32,"n_cols":14,"rows_kept":32,"cut":false,"hidden":false,"merged":[[0,0,0,6]]}
["Supplementary Table 5. Genomic annotations and functional consequences of fine-mapped SNPs.\n"]
["SNP","CHR","BP ","Name of GWS locus^","VEP Gene","Gene Ensembl ID","Transcript Ensembl ID","VEP Consequence","RegulomeDB ranking","RegulomeDB probability","Index SNP","Closest Gene†","pLI (VEP Gene)","LOEUF (VEP Gene)"]
["rs17183814",2.0,1.66152389E8,"SCN2A ","SCN2A","ENSG00000136531","ENST00000283256.6","missense",5.0,0.13454,"yes","yes",1.0,0.16]
["rs1529668",2.0,1.6622028E8,"SCN2A","SCN2A","ENSG00000136531","ENST00000283256.6","intronic",5.0,0.58955,"no","yes",1.0,0.16]
["rs9834970",3.0,3.685603E7,"TRANK1 ","-","-","ENSR00001657107","regulatory",4.0,0.60906,"yes","yes","-","-"]
["rs28360326",5.0,8.2631163E7,"SSBP2","XRCC4","ENSG00000152422","ENST00000282268.3","intronic",6.0,0.34125,"no","no",0.0,1.03]
["rs11134593",5.0,1.69289635E8,"DOCK2","DOCK2","ENSG00000134516","ENST00000256935.8","intronic",4.0,0.70497,"no","yes",1.0,0.42]
["rs4331993",6.0,1.52793572E8,"SYNE1","SYNE1","ENSG00000131018","ENST00000468937.2","non coding transcript exon variant","2b",0.76502,"yes","yes",0.0,0.56]
["rs113779084",7.0,1.1871787E7,"THSD7A","THSD7A","ENSG00000005108","ENST00000423059.4","5' UTR",4.0,0.70497,"yes","yes",0.01,0.5]
["rs11764361",7.0,1.05043229E8,"SRPK2","SRPK2","ENSG00000135250","ENST00000462282.1","upstream",5.0,0.8475,"yes","yes",1.0,0.35]
["rs62489493",8.0,9763581.0,"MIR124-1","LINC00599","ENSG00000284321","ENST00000385275.1","upstream",4.0,0.60906,"yes","yes","-","-"]
["rs10867108",9.0,1.41017969E8,"TUBBP5","CACNA1B","ENSG00000148408","ENST00000277549.5","3' UTR","2b",0.73193,"no","no",1.0,0.42]
["rs11549690",11.0,6.3991581E7,"FADS2","TRPT1","ENSG00000149743","ENST00000317459.6","missense",4.0,0.60906,"no","no",0.0,1.23]
["rs4672",11.0,6.4009879E7,"FKBP2","FKBP2","ENSG00000173486","ENST00000309366.4","missense",4.0,0.60906,"yes","yes",0.0,1.22]
["rs12575685",11.0,7.0517927E7,"SHANK2","SHANK2","ENSG00000162105","ENST00000294018.4","intronic",5.0,0.13454,"yes","yes",1.0,0.42]
["rs12148859",15.0,3.8982646E7,"C15orf53","LINC02694","ENSG00000175779","ENST00000560203.1","downstream",4.0,0.60906,"no","yes","-","-"]
["rs4702",15.0,9.142656E7,"FURIN","FURIN","ENSG00000140564","ENST00000268171.3","3' UTR",4.0,0.60906,"yes","yes",1.0,0.3]
["rs28455634",16.0,9230816.0,"C16orf72","-","-","-","intergenic",5.0,0.13454,"yes","-","-","-"]
["rs12932628",16.0,8.9632725E7,"RPL13","RPL13","ENSG00000167526","ENST00000311528.5","downstream",4.0,0.70497,"yes","yes",1.0,0.25]
["rs9896486",17.0,1252843.0,"RTN4RL1","YWHAE","ENSG00000108953","ENST00000264335.8","intronic",5.0,0.58955,"no","no",1.0,0.17]
["rs4790841",17.0,1835482.0,"RTN4RL1","RTN4RL1","ENSG00000185924","ENST00000331238.6","downstream",4.0,0.60906,"yes","yes",0.77,0.63]
["rs11870683",17.0,3.8129841E7,"ERBB2","GSDMA","ENSG00000167914","ENST00000301659.4","intronic",4.0,0.60906,"yes","yes",0.0,1.24]
["rs61554907",17.0,3.8220432E7,"ERBB2","THRA","ENSG00000126351","ENST00000264637.4","intronic",4.0,0.60906,"yes","yes",1.0,0.44]
["rs880447",20.0,6.2133276E7,"OSBPL2","EEF1A2","ENSG00000101210","ENST00000217182.3","upstream",4.0,0.60906,"no","no",1.0,0.31]
[]
["CHR, BP, Ensembl Gene Identifiers, Ensembl Transcript Identifiers and MANE transcript annotations are based on GRCh37;"]
["VEP consequence, variant consequence for each consensus SNP as predicted by VEP plugin;"]
["RegulomeDB ranking and probability scores: ranking scores range from 1 to 7, with a score of 1 indicating a strong evidence of functionality, while a score of 7 suggests minimal or no evidence of functionality. Within a numeric category, variants are also annotated from most to least confident in alphabetical order; a variant with a probability score of 1 is most likely to be a regulatory variant;"]
["^Genome-wide significant locus names as defined in the GWAS publication (Mullins et al., Nat Genet, 2021);"]
["†Closest gene indicates whether the VEP annotated gene is the closest to the index SNP from the GWAS"]
["pLI score, tolerance of a given gene to the loss of function on the basis of the number of protein truncating variants; genes with LOEUF< 0.6 or pLI ≥0.9 are classified as highly intolerant to loss-of-function mutations (gnomAD v.4.0.0);"]
["All base pair positions are on GRCh37."]

{"sheet":"Table S6","index":6,"n_rows":93,"n_cols":22,"rows_kept":93,"cut":false,"hidden":false,"merged":[[0,0,0,11],[90,0,90,14],[91,0,91,15],[92,0,92,2]]}
["Supplementary Table 6. Significant SMR results from BrainMeta eQTL and sQTL data and Brain-mMeta mQTL data for union consensus SNPs."]
["Dataset","Probe ID","CHR","Gene","Probe position","topSNP","topSNP CHR","topSNP position","A1","A2","Freq A1","beta GWAS","se GWAS","P value GWAS","beta eQTL","se eQTL","P value eQTL","beta SMR","se SMR","P value SMR*","P value HEIDI^","nsnp_HEIDI"]
["eQTL","ENSG00000163673.7",3.0,"DCLK3",3.6779876E7,"rs9834970",3.0,3.685603E7,"T","C",0.507,-0.083,0.009,6.63E-19,0.262,0.028,8.26E-21,-0.317,0.049,1.06E-10,0.118,20.0]
["eQTL","ENSG00000168016.15",3.0,"TRANK1",3.6927429E7,"rs9834970",3.0,3.685603E7,"T","C",0.507,-0.083,0.009,6.63E-19,0.289,0.032,1.83E-19,-0.288,0.045,2.22E-10,0.033,20.0]
["eQTL","ENSG00000148408.13",9.0,"CACNA1B",1.40895655E8,"rs10867108",9.0,1.41017969E8,"T","C",0.384,0.059,0.011,4.15E-8,0.375,0.031,4.23E-34,0.157,0.032,6.23E-7,0.034,20.0]
["eQTL","ENSG00000286264.2",11.0,"AP001453.3",6.4010086E7,"rs11549690",11.0,6.3991581E7,"A","G",0.073,0.097,0.018,6.66E-8,0.392,0.057,8.1E-12,0.246,0.058,2.28E-5,0.534,20.0]
["eQTL","ENSG00000149782.13",11.0,"PLCB3",6.4027812E7,"rs11549690",11.0,6.3991581E7,"A","G",0.073,0.097,0.018,6.66E-8,0.402,0.056,7.57E-13,0.24,0.056,1.62E-5,0.021,20.0]
["eQTL","ENSG00000182450.13",11.0,"KCNK4",6.4063138E7,"rs11549690",11.0,6.3991581E7,"A","G",0.073,0.097,0.018,6.66E-8,0.419,0.062,1.42E-11,0.23,0.055,2.48E-5,0.024,20.0]
["eQTL","ENSG00000126432.14",11.0,"PRDX5",6.4087438E7,"rs11549690",11.0,6.3991581E7,"A","G",0.073,0.097,0.018,6.66E-8,-0.363,0.06,1.52E-9,-0.266,0.066,5.7E-5,0.014,20.0]
["eQTL","ENSG00000286264.2",11.0,"AP001453.3",6.4010086E7,"rs4672",11.0,6.4009879E7,"A","G",0.079,0.102,0.017,3.42E-9,0.422,0.055,1.94E-14,0.241,0.052,2.88E-6,0.534,20.0]
["eQTL","ENSG00000149782.13",11.0,"PLCB3",6.4027812E7,"rs4672",11.0,6.4009879E7,"A","G",0.079,0.102,0.017,3.42E-9,0.416,0.054,1.47E-14,0.244,0.052,2.77E-6,0.021,20.0]
["eQTL","ENSG00000182450.13",11.0,"KCNK4",6.4063138E7,"rs4672",11.0,6.4009879E7,"A","G",0.079,0.102,0.017,3.42E-9,0.453,0.06,2.69E-14,0.224,0.048,3.02E-6,0.024,20.0]
["eQTL","ENSG00000126432.14",11.0,"PRDX5",6.4087438E7,"rs4672",11.0,6.4009879E7,"A","G",0.079,0.102,0.017,3.42E-9,-0.409,0.057,1.15E-12,-0.249,0.055,5.46E-6,0.014,20.0]
["eQTL","ENSG00000140564.13",15.0,"FURIN",9.1419306E7,"rs4702",15.0,9.142656E7,"G","A",0.449,0.057,0.01,3.52E-9,-0.454,0.03,3.57E-53,-0.126,0.023,3.53E-8,0.308,20.0]
["eQTL","ENSG00000182511.12",15.0,"FES",9.1432966E7,"rs4702",15.0,9.142656E7,"G","A",0.449,0.057,0.01,3.52E-9,0.252,0.03,2.56E-17,0.227,0.047,1.27E-6,0.024,19.0]
["eQTL","ENSG00000101210.13",20.0,"EEF1A2",6.2124979E7,"rs880447",20.0,6.2133276E7,"C","G",0.416,0.053,0.011,5.79E-7,0.189,0.033,1.13E-8,0.278,0.074,1.69E-4,0.022,20.0]
["sQTL","chr2:166096150:166152283:clu_239009_",2.0,"SCN2A",1.66124216E8,"rs1529668",2.0,1.6622028E8,"A","T",0.066,-0.105,0.019,3.88E-8,0.395,0.055,6.63E-13,-0.265,0.061,1.31E-5,0.219,4.0]
["sQTL","chr2:166096150:166152390:clu_239009_",2.0,"SCN2A",1.6612427E8,"rs1529668",2.0,1.6622028E8,"A","T",0.066,-0.105,0.019,3.88E-8,-0.992,0.051,1.07E-84,0.106,0.02,1.31E-7,0.179,20.0]
["sQTL","chr2:166096150:166152283:clu_239009_",2.0,"SCN2A",1.66124216E8,"rs17183814",2.0,1.66152389E8,"A","G",0.07,-0.103,0.019,2.68E-8,0.407,0.055,1.9E-13,-0.253,0.057,9.14E-6,0.219,4.0]
["sQTL","chr2:166096150:166152390:clu_239009_",2.0,"SCN2A",1.6612427E8,"rs17183814",2.0,1.66152389E8,"A","G",0.07,-0.103,0.019,2.68E-8,-1.041,0.051,7.16E-93,0.099,0.018,8.01E-8,0.179,20.0]
["sQTL","chr9:141013220:141013595:clu_134277_",9.0,"CACNA1B",1.41013408E8,"rs10867108",9.0,1.41017969E8,"T","C",0.384,0.059,0.011,4.15E-8,0.175,0.03,3.33E-9,0.338,0.084,6.0E-5,0.229,20.0]
["sQTL","chr9:141044760:141045176:clu_134283_",9.0,"TUBBP5",1.41044968E8,"rs10867108",9.0,1.41017969E8,"T","C",0.384,0.059,0.011,4.15E-8,-0.181,0.029,2.5E-10,-0.326,0.079,3.55E-5,0.071,20.0]
["sQTL","chr9:141044760:141051804:clu_134283_",9.0,"TUBBP5",1.41048282E8,"rs10867108",9.0,1.41017969E8,"T","C",0.384,0.059,0.011,4.15E-8,-0.185,0.03,9.94E-10,-0.318,0.078,4.65E-5,0.063,20.0]
["sQTL","chr9:141045293:141051804:clu_134283_",9.0,"TUBBP5",1.41048548E8,"rs10867108",9.0,1.41017969E8,"T","C",0.384,0.059,0.011,4.15E-8,-0.187,0.029,1.59E-10,-0.315,0.076,3.27E-5,0.046,20.0]
["sQTL","chr9:141051921:141052124:clu_134283_",9.0,"TUBBP5",1.41052022E8,"rs10867108",9.0,1.41017969E8,"T","C",0.384,0.059,0.011,4.15E-8,-0.212,0.03,7.57E-13,-0.279,0.064,1.39E-5,0.03,20.0]
["sQTL","chr9:141044760:141068594:clu_134283_",9.0,"TUBBP5",1.41056677E8,"rs10867108",9.0,1.41017969E8,"T","C",0.384,0.059,0.011,4.15E-8,-0.241,0.033,2.28E-13,-0.245,0.056,1.19E-5,0.014,20.0]
["sQTL","chr9:141044760:141068822:clu_134283_",9.0,"TUBBP5",1.41056791E8,"rs10867108",9.0,1.41017969E8,"T","C",0.384,0.059,0.011,4.15E-8,-0.172,0.03,5.2E-9,-0.342,0.086,6.62E-5,0.288,20.0]
["sQTL","chr9:141044760:141068825:clu_134283_",9.0,"TUBBP5",1.41056792E8,"rs10867108",9.0,1.41017969E8,"T","C",0.384,0.059,0.011,4.15E-8,-0.217,0.03,7.1E-13,-0.271,0.062,1.38E-5,0.051,20.0]
["sQTL","chr9:141045293:141068498:clu_134283_",9.0,"TUBBP5",1.41056896E8,"rs10867108",9.0,1.41017969E8,"T","C",0.384,0.059,0.011,4.15E-8,-0.216,0.028,2.48E-14,-0.273,0.062,8.98E-6,0.028,20.0]
["sQTL","chr9:141045293:141068594:clu_134283_",9.0,"TUBBP5",1.41056944E8,"rs10867108",9.0,1.41017969E8,"T","C",0.384,0.059,0.011,4.15E-8,-0.226,0.03,9.74E-14,-0.261,0.059,1.06E-5,0.036,20.0]
["sQTL","chr9:141045293:141068822:clu_134283_",9.0,"TUBBP5",1.41057058E8,"rs10867108",9.0,1.41017969E8,"T","C",0.384,0.059,0.011,4.15E-8,-0.198,0.029,1.5E-11,-0.298,0.07,2.18E-5,0.051,20.0]
["sQTL","chr9:141044760:141069815:clu_134283_",9.0,"TUBBP5",1.41057288E8,"rs10867108",9.0,1.41017969E8,"T","C",0.384,0.059,0.011,4.15E-8,-0.224,0.03,1.39E-13,-0.263,0.06,1.11E-5,0.045,20.0]
["sQTL","chr9:141051921:141068498:clu_134283_",9.0,"TUBBP5",1.4106021E8,"rs10867108",9.0,1.41017969E8,"T","C",0.384,0.059,0.011,4.15E-8,-0.182,0.031,3.95E-9,-0.325,0.081,6.23E-5,0.247,20.0]
["sQTL","chr9:141051921:141068594:clu_134283_",9.0,"TUBBP5",1.41060258E8,"rs10867108",9.0,1.41017969E8,"T","C",0.384,0.059,0.011,4.15E-8,-0.222,0.03,2.75E-13,-0.266,0.061,1.21E-5,0.049,20.0]
["sQTL","chr9:141051921:141068822:clu_134283_",9.0,"TUBBP5",1.41060372E8,"rs10867108",9.0,1.41017969E8,"T","C",0.384,0.059,0.011,4.15E-8,-0.203,0.029,3.95E-12,-0.29,0.068,1.77E-5,0.056,20.0]
["sQTL","chr9:141069552:141069815:clu_134283_",9.0,"TUBBP5",1.41069684E8,"rs10867108",9.0,1.41017969E8,"T","C",0.384,0.059,0.011,4.15E-8,-0.216,0.029,2.12E-13,-0.273,0.062,1.17E-5,0.023,20.0]
["sQTL","chr11:63991439:63991572:clu_13850_",11.0,"TRPT1",6.3991506E7,"rs11549690",11.0,6.3991581E7,"A","G",0.073,0.097,0.018,6.66E-8,-0.779,0.055,2.75E-46,-0.124,0.025,4.46E-7,0.064,20.0]
["sQTL","chr11:63991439:63991757:clu_13850_",11.0,"TRPT1",6.3991598E7,"rs11549690",11.0,6.3991581E7,"A","G",0.073,0.097,0.018,6.66E-8,1.426,0.052,4.96E-168,0.068,0.013,1.18E-7,0.481,20.0]
["sQTL","chr11:63991634:63991757:clu_13850_",11.0,"TRPT1",6.3991696E7,"rs11549690",11.0,6.3991581E7,"A","G",0.073,0.097,0.018,6.66E-8,-0.391,0.055,8.02E-13,-0.247,0.057,1.63E-5,0.141,20.0]
["sQTL","chr11:63991682:63991757:clu_13850_",11.0,"TRPT1",6.399172E7,"rs11549690",11.0,6.3991581E7,"A","G",0.073,0.097,0.018,6.66E-8,0.477,0.049,3.87E-22,0.202,0.043,2.44E-6,0.07,20.0]
["sQTL","chr11:63991963:63992971:clu_13852_",11.0,"TRPT1",6.3992467E7,"rs11549690",11.0,6.3991581E7,"A","G",0.073,0.097,0.018,6.66E-8,-0.397,0.06,4.89E-11,-0.243,0.058,3.03E-5,0.154,20.0]
["sQTL","ENSG00000110011.13",11.0,"DNAJC4",6.3999754E7,"rs11549690",11.0,6.3991581E7,"A","G",0.073,0.097,0.018,6.66E-8,0.107,0.017,5.58E-10,0.907,0.223,4.68E-5,0.024,20.0]
["sQTL","chr11:64008710:64009856:clu_290466_",11.0,"FKBP2",6.4009283E7,"rs11549690",11.0,6.3991581E7,"A","G",0.073,0.097,0.018,6.66E-8,-0.386,0.053,2.26E-13,-0.25,0.058,1.38E-5,0.14,20.0]
["sQTL","chr11:64009006:64009856:clu_290466_",11.0,"FKBP2",6.4009431E7,"rs11549690",11.0,6.3991581E7,"A","G",0.073,0.097,0.018,6.66E-8,-0.327,0.057,1.1E-8,-0.296,0.075,8.73E-5,0.486,20.0]
["sQTL","chr11:64009685:64009856:clu_290466_",11.0,"FKBP2",6.400977E7,"rs11549690",11.0,6.3991581E7,"A","G",0.073,0.097,0.018,6.66E-8,0.299,0.05,2.68E-9,0.323,0.081,6.41E-5,0.187,20.0]
["sQTL","ENSG00000286264.2",11.0,"AP001453.3",6.4010085E7,"rs11549690",11.0,6.3991581E7,"A","G",0.073,0.097,0.018,6.66E-8,0.136,0.017,2.84E-15,0.712,0.16,8.36E-6,0.048,20.0]
["sQTL","chr11:64087340:64088337:clu_290506_",11.0,"PRDX5",6.4087838E7,"rs11549690",11.0,6.3991581E7,"A","G",0.073,0.097,0.018,6.66E-8,-0.32,0.056,9.86E-9,-0.302,0.077,8.51E-5,0.045,20.0]
["sQTL","chr11:63991439:63991572:clu_13850_",11.0,"TRPT1",6.3991506E7,"rs4672",11.0,6.4009879E7,"A","G",0.079,0.102,0.017,3.42E-9,-0.642,0.053,2.9E-33,-0.158,0.03,1.12E-7,0.064,20.0]
["sQTL","chr11:63991439:63991757:clu_13850_",11.0,"TRPT1",6.3991598E7,"rs4672",11.0,6.4009879E7,"A","G",0.079,0.102,0.017,3.42E-9,1.292,0.051,1.33E-141,0.079,0.014,8.51E-9,0.526,20.0]
["sQTL","chr11:63991634:63991757:clu_13850_",11.0,"TRPT1",6.3991696E7,"rs4672",11.0,6.4009879E7,"A","G",0.079,0.102,0.017,3.42E-9,-0.376,0.053,9.43E-13,-0.271,0.059,5.27E-6,0.141,20.0]
["sQTL","chr11:63991682:63991757:clu_13850_",11.0,"TRPT1",6.399172E7,"rs4672",11.0,6.4009879E7,"A","G",0.079,0.102,0.017,3.42E-9,0.366,0.048,4.22E-14,0.278,0.06,3.22E-6,0.07,20.0]
["sQTL","chr11:63991963:63992971:clu_13852_",11.0,"TRPT1",6.3992467E7,"rs4672",11.0,6.4009879E7,"A","G",0.079,0.102,0.017,3.42E-9,-0.358,0.058,7.83E-10,-0.284,0.067,2.03E-5,0.154,20.0]
["sQTL","ENSG00000110011.13",11.0,"DNAJC4",6.3999754E7,"rs4672",11.0,6.4009879E7,"A","G",0.079,0.102,0.017,3.42E-9,0.099,0.016,2.38E-10,1.024,0.237,1.54E-5,0.024,20.0]
["sQTL","chr11:64008710:64009856:clu_290466_",11.0,"FKBP2",6.4009283E7,"rs4672",11.0,6.4009879E7,"A","G",0.079,0.102,0.017,3.42E-9,-0.404,0.051,1.24E-15,-0.251,0.053,1.98E-6,0.14,20.0]
["sQTL","chr11:64009006:64009856:clu_290466_",11.0,"FKBP2",6.4009431E7,"rs4672",11.0,6.4009879E7,"A","G",0.079,0.102,0.017,3.42E-9,-0.391,0.054,6.87E-13,-0.26,0.057,5.0E-6,0.486,20.0]
["sQTL","chr11:64009685:64009856:clu_290466_",11.0,"FKBP2",6.400977E7,"rs4672",11.0,6.4009879E7,"A","G",0.079,0.102,0.017,3.42E-9,0.325,0.048,1.17E-11,0.313,0.07,8.29E-6,0.187,20.0]
["sQTL","ENSG00000286264.2",11.0,"AP001453.3",6.4010085E7,"rs4672",11.0,6.4009879E7,"A","G",0.079,0.102,0.017,3.42E-9,0.136,0.016,3.51E-18,0.746,0.153,1.01E-6,0.048,20.0]
["sQTL","chr11:64087340:64088337:clu_290506_",11.0,"PRDX5",6.4087838E7,"rs4672",11.0,6.4009879E7,"A","G",0.079,0.102,0.017,3.42E-9,-0.319,0.054,2.45E-9,-0.319,0.076,2.68E-5,0.045,20.0]
["sQTL","chr15:91427774:91428267:clu_231620_",15.0,"FES",9.142802E7,"rs4702",15.0,9.142656E7,"G","A",0.449,0.057,0.01,3.52E-9,-0.213,0.027,3.12E-15,-0.269,0.057,2.27E-6,0.023,20.0]
["sQTL","chr17:38064454:38065211:clu_149449_",17.0,"GSDMB",3.8064832E7,"rs11870683",17.0,3.8129841E7,"A","T",0.361,-0.057,0.01,2.79E-8,0.32,0.041,1.05E-14,-0.179,0.04,6.31E-6,0.14,20.0]
["sQTL","chr17:38064467:38065211:clu_149449_",17.0,"GSDMB",3.8064839E7,"rs11870683",17.0,3.8129841E7,"A","T",0.361,-0.057,0.01,2.79E-8,-0.23,0.037,3.18E-10,0.249,0.06,3.09E-5,0.034,20.0]
["sQTL","chr17:38176263:38176526:clu_149493_",17.0,"MED24",3.8176394E7,"rs11870683",17.0,3.8129841E7,"A","T",0.361,-0.057,0.01,2.79E-8,0.202,0.028,7.12E-13,-0.284,0.065,1.1E-5,0.116,20.0]
["sQTL","chr17:38176606:38176781:clu_149494_",17.0,"MED24",3.8176694E7,"rs11870683",17.0,3.8129841E7,"A","T",0.361,-0.057,0.01,2.79E-8,0.199,0.028,6.5E-13,-0.288,0.066,1.08E-5,0.015,20.0]
["sQTL","chr17:38176872:38178208:clu_149494_",17.0,"MED24",3.817754E7,"rs11870683",17.0,3.8129841E7,"A","T",0.361,-0.057,0.01,2.79E-8,0.254,0.027,1.5E-21,-0.226,0.047,1.55E-6,0.1,20.0]
["sQTL","chr17:1268352:1273003:clu_144985_",17.0,"YWHAE",1270678.0,"rs9896486",17.0,1252843.0,"T","G",0.404,0.052,0.01,5.91E-8,-0.191,0.027,1.47E-12,-0.269,0.063,1.68E-5,0.03,20.0]
["mQTL","cg00528902",8.0,null,9760528.0,"rs62489493",8.0,9763581.0,"C","G",0.865,-0.09,0.014,2.64E-11,-0.556,0.063,1.14E-18,0.161,0.03,1.11E-7,0.109,20.0]
["mQTL","cg23585835",8.0,null,9764602.0,"rs62489493",8.0,9763581.0,"C","G",0.865,-0.09,0.014,2.64E-11,0.49,0.088,2.94E-8,-0.183,0.043,2.07E-5,0.138,20.0]
["mQTL","cg11269159",8.0,null,9788745.0,"rs62489493",8.0,9763581.0,"C","G",0.865,-0.09,0.014,2.64E-11,0.674,0.086,4.31E-15,-0.133,0.026,3.97E-7,0.37,20.0]
["mQTL","cg13811936",9.0,null,1.41017001E8,"rs10867108",9.0,1.41017969E8,"T","C",0.384,0.059,0.011,4.15E-8,0.285,0.047,1.1E-9,0.207,0.051,4.75E-5,0.036,8.0]
["mQTL","cg14078730",11.0,null,6.3896557E7,"rs11549690",11.0,6.3991581E7,"G","A",0.927,-0.097,0.018,6.66E-8,-0.744,0.118,2.5E-10,0.13,0.032,4.03E-5,0.023,20.0]
["mQTL","cg19270469",11.0,null,6.4023919E7,"rs11549690",11.0,6.3991581E7,"G","A",0.927,-0.097,0.018,6.66E-8,0.764,0.117,7.7E-11,-0.126,0.03,3.27E-5,0.014,18.0]
["mQTL","cg11279857",11.0,"FKBP2",6.4009878E7,"rs4672",11.0,6.4009879E7,"G","A",0.921,-0.102,0.017,3.42E-9,1.749,0.112,2.12E-55,-0.058,0.011,3.16E-8,0.643,7.0]
["mQTL","cg26204322",11.0,"PLCB3",6.4018687E7,"rs4672",11.0,6.4009879E7,"G","A",0.921,-0.102,0.017,3.42E-9,-1.031,0.127,5.9E-16,0.099,0.021,1.81E-6,0.028,6.0]
["mQTL","cg19270469",11.0,null,6.4023919E7,"rs4672",11.0,6.4009879E7,"G","A",0.921,-0.102,0.017,3.42E-9,0.786,0.115,9.74E-12,-0.129,0.029,8.01E-6,0.014,18.0]
["mQTL","cg26377677",15.0,null,9.1412118E7,"rs4702",15.0,9.142656E7,"G","A",0.449,0.057,0.01,3.52E-9,-0.482,0.06,8.13E-16,-0.119,0.025,1.91E-6,0.204,15.0]
["mQTL","cg24888049",15.0,null,9.1426667E7,"rs4702",15.0,9.142656E7,"G","A",0.449,0.057,0.01,3.52E-9,-0.49,0.044,2.98E-28,-0.117,0.022,1.93E-7,0.048,14.0]
["mQTL","cg09397246",15.0,null,9.1427361E7,"rs4702",15.0,9.142656E7,"G","A",0.449,0.057,0.01,3.52E-9,-0.3,0.046,7.65E-11,-0.191,0.044,1.22E-5,0.048,10.0]
["mQTL","cg18661868",15.0,null,9.1427965E7,"rs4702",15.0,9.142656E7,"G","A",0.449,0.057,0.01,3.52E-9,-0.342,0.062,2.92E-8,-0.167,0.041,5.27E-5,0.138,9.0]
["mQTL","cg26899598",15.0,null,9.1429088E7,"rs4702",15.0,9.142656E7,"G","A",0.449,0.057,0.01,3.52E-9,-0.35,0.046,1.74E-14,-0.164,0.035,2.87E-6,0.056,14.0]
["mQTL","cg03784048",16.0,null,9229746.0,"rs28455634",16.0,9230816.0,"G","A",0.623,0.063,0.01,2.63E-10,-0.513,0.063,3.28E-16,-0.122,0.024,5.48E-7,0.021,20.0]
["mQTL","cg17142404",17.0,null,1838200.0,"rs4790841",17.0,1835482.0,"C","T",0.847,-0.073,0.013,3.14E-8,0.589,0.066,6.52E-19,-0.124,0.026,2.73E-6,0.105,20.0]
["mQTL","cg15524101",17.0,null,1838264.0,"rs4790841",17.0,1835482.0,"C","T",0.847,-0.073,0.013,3.14E-8,0.735,0.064,2.57E-30,-0.099,0.02,6.56E-7,0.02,20.0]
["mQTL","cg03214325",17.0,null,1850539.0,"rs4790841",17.0,1835482.0,"C","T",0.847,-0.073,0.013,3.14E-8,-1.506,0.041,5.99E-291,0.048,0.009,4.74E-8,0.016,20.0]
["mQTL","cg08892455",17.0,null,1231715.0,"rs9896486",17.0,1252843.0,"G","T",0.596,-0.052,0.01,5.91E-8,0.426,0.062,6.69E-12,-0.121,0.028,2.1E-5,0.016,20.0]
["mQTL","cg10057218",17.0,null,3.8074149E7,"rs11870683",17.0,3.8129841E7,"T","A",0.639,0.057,0.01,2.79E-8,-0.356,0.064,3.18E-8,-0.161,0.041,8.77E-5,0.109,20.0]
["mQTL","cg26162295",17.0,null,3.8119207E7,"rs11870683",17.0,3.8129841E7,"T","A",0.639,0.057,0.01,2.79E-8,-0.297,0.048,5.72E-10,-0.193,0.047,3.47E-5,0.06,20.0]
["mQTL","cg03671276",17.0,null,3.818337E7,"rs11870683",17.0,3.8129841E7,"T","A",0.639,0.057,0.01,2.79E-8,-0.532,0.062,7.11E-18,-0.108,0.023,2.97E-6,0.033,20.0]
["mQTL","cg03568305",17.0,null,3.8183559E7,"rs11870683",17.0,3.8129841E7,"T","A",0.639,0.057,0.01,2.79E-8,1.263,0.034,1.0E-300,0.045,0.008,3.77E-8,0.055,20.0]
["mQTL","cg04602939",20.0,null,6.2184207E7,"rs880447",20.0,6.2133276E7,"C","G",0.416,0.053,0.011,5.79E-7,0.404,0.063,1.31E-10,0.13,0.033,7.94E-5,0.265,20.0]
[]
["CHR, chromosome; A1 is the effect allele, A2 is the other allele; Freq, frequency; se, standard error; nsnp, number of SNPs; P values are based on the tests indicated and are shown uncorrected and two-sided."]
["*The Bonferroni corrected significance threshold is P < 8.64e-05 for BrainMeta eQTL and P < 2.21e-05 for BrainMeta sQTL and P < 1.11e-03 for Brain-mMeta mQTL.  ^A probe with HEIDI P value >= 0.01 passes the HEIDI test. "]
["All base pair positions are on GRCh37."]

{"sheet":"Table S7","index":7,"n_rows":53,"n_cols":15,"rows_kept":53,"cut":false,"hidden":false,"merged":[[0,0,0,12],[48,0,48,9]]}
["Supplementary Table 7. HLA variants with P < 5e-06 for association with bipolar disorder. "]
["CHR","Variant^","Variant Type","BP","A1†","A2†","A1 freq in cases","A1 freq in controls","INFO","OR (A1  allele)","Beta (A1 allele)","SE","P","Direction*","Neff_half"]
[6.0,"HLA_C_0701","Classical HLA Allele",3.1238192E7,"Present","Absent",0.146,0.155,1.0,0.911,{"$f":"log(J3,2.71828)","v":-0.09321244442},0.015,3.4E-10,"++--++++-++-+-+++++++-++--+-+-++++++++++-+++++++",37286.34]
[6.0,"AA_C_66_31347429","HLA Amino Acid",3.123945E7,"N","K",0.176,0.185,0.998,0.919,-0.08446921344,0.014,8.96E-10,"++--+++++++-+-+++++++-++--++++++++-+++++-+++++++",37286.34]
[6.0,"SNP_C_31347428","HLA intragenic SNP",3.1239449E7,"G","C",0.176,0.185,0.998,0.919,-0.08446921344,0.014,8.97E-10,"++--+++++++-+-+++++++-++--++++++++-+++++-+++++++",37286.34]
[6.0,"SNP_B_31430769","HLA intragenic SNP",3.132279E7,"A","T",0.12,0.127,1.0,0.914,-0.08992476802,0.016,2.49E-8,"---+----+--+-------?-+---+-+++----------+-----+-",37167.79]
[6.0,"SNP_B_31431395","HLA intragenic SNP",3.1323416E7,"C","G",0.12,0.127,1.0,0.914,-0.08992476802,0.016,2.5E-8,"---+----+--+-------?-+---+-+++----------+-----+-",37167.79]
[6.0,"SNP_B_31431485","HLA intragenic SNP",3.1323506E7,"T","C",0.12,0.127,1.0,0.914,-0.08992476802,0.016,2.5E-8,"---+----+--+-------?-+---+-+++----------+-----+-",37167.79]
[6.0,"AA_B_9_31432689_D","HLA Amino Acid",3.132471E7,"Present","Absent",0.111,0.118,1.0,0.912,-0.09211535087,0.017,4.05E-8,"+++-++++-++-++++++??+-++--+---++++++++++-+++++-+",37077.27]
[6.0,"SNP_B_31432690_C","HLA intragenic SNP",3.1324711E7,"Present","Absent",0.111,0.118,1.0,0.912,-0.09211535087,0.017,4.05E-8,"+++-++++-++-++++++??+-++--+---++++++++++-+++++-+",37077.27]
[6.0,"HLA_B_08","Classical HLA Allele",3.1323293E7,"Present","Absent",0.111,0.118,1.0,0.912,-0.09211535087,0.017,4.08E-8,"+++-++++-++-++++++??+-++--+---++++++++++-+++++-+",37077.27]
[6.0,"HLA_B_0801","Classical HLA Allele",3.1323293E7,"Present","Absent",0.111,0.118,1.0,0.912,-0.09211535087,0.017,4.08E-8,"+++-++++-++-++++++??+-++--+---++++++++++-+++++-+",37077.27]
[6.0,"SNP_C_31346830","HLA intragenic SNP",3.1238851E7,"T","C",0.297,0.307,1.0,0.944,-0.0576291516,0.012,5.06E-7,"+--+--------------+--+-----------+------+--+----",37286.34]
[6.0,"SNP_C_31345428","HLA intragenic SNP",3.1237449E7,"T","C",0.297,0.307,1.0,0.944,-0.0576291516,0.012,5.09E-7,"+--+--------------+--+-----------+------+--+----",37286.34]
[6.0,"SNP_C_31346962_G","HLA intragenic SNP",3.1238983E7,"Present","Absent",0.351,0.362,1.0,0.946,-0.05551274727,0.011,7.39E-7,"+++-++++++++++++++-++-+++++++++-+-++++++-++-++++",37286.34]
[6.0,"SNP_B_31432394","HLA intragenic SNP",3.1324415E7,"C","A",0.175,0.181,0.999,0.935,-0.0672087949,0.014,1.07E-6,"-++-+++--+--+++++++++-+---+----++-+++++++++++-++",37286.34]
[6.0,"SNP_C_31346738","HLA intragenic SNP",3.1238759E7,"C","T",0.438,0.449,1.01,0.951,-0.05024125023,0.011,2.77E-6,"-++-++++++++++-++++++-++--+++-+-++-++++++++-+-++",37286.34]
[6.0,"AA_C_339_31345102_A","HLA Amino Acid",3.1237123E7,"Present","Absent",0.679,0.67,1.01,1.054,0.0525924855,0.011,3.12E-6,"---+--------------+--+---+---+-+-+--+------+----",37286.34]
[6.0,"AA_C_326_31345141_S","HLA Amino Acid",3.1237162E7,"Present","Absent",0.679,0.67,1.01,1.054,0.0525924855,0.011,3.14E-6,"---+--------------+--+---+---+-+-+--+------+----",37286.34]
[6.0,"SNP_C_31344996","HLA intragenic SNP",3.1237017E7,"C","T",0.324,0.333,1.01,0.95,-0.05129332889,0.011,4.68E-6,"-++-+++++++++++++++++-+++-+++-+-+-++-+++++++++++",37286.34]
[6.0,"SNP_C_31345006","HLA intragenic SNP",3.1237027E7,"C","T",0.324,0.333,1.01,0.95,-0.05129332889,0.011,4.68E-6,"-++-+++++++++++++++++-+++-+++-+-+-++-+++++++++++",37286.34]
[6.0,"SNP_C_31345212","HLA intragenic SNP",3.1237233E7,"A","G",0.324,0.333,1.01,0.95,-0.05129332889,0.011,4.69E-6,"+--+-----------------+---+---+-+-+--+-----------",37286.34]
[6.0,"SNP_C_31346962_C","HLA intragenic SNP",3.1238983E7,"Present","Absent",0.602,0.592,1.0,1.051,0.04974212535,0.011,4.72E-6,"---+----++-++--+--+--+---+-----+-+--+---+--+----",37286.34]
[6.0,"AA_C_306_31345748_V","HLA Amino Acid",3.1237769E7,"Present","Absent",0.676,0.667,1.01,1.053,0.05164326789,0.011,4.78E-6,"+--+-----------------+---+---+-+-+--+-----------",37286.34]
[6.0,"AA_C_285_31345811_V","HLA Amino Acid",3.1237832E7,"Present","Absent",0.676,0.667,1.01,1.053,0.05164326789,0.011,4.78E-6,"+--+-----------------+---+---+-+-+--+-----------",37286.34]
[6.0,"SNP_C_31345753","HLA intragenic SNP",3.1237774E7,"G","C",0.324,0.333,1.01,0.95,-0.05129332889,0.011,4.83E-6,"-++-+++++++++++++++++-+++-+++-+-+-++-+++++++++++",37286.34]
[6.0,"AA_C_306_31345748_A","HLA Amino Acid",3.1237769E7,"Present","Absent",0.324,0.333,1.01,0.95,-0.05129332889,0.011,4.84E-6,"-++-+++++++++++++++++-+++-+++-+-+-++-+++++++++++",37286.34]
[6.0,"SNP_C_31345748","HLA intragenic SNP",3.1237769E7,"G","A",0.324,0.333,1.01,0.95,-0.05129332889,0.011,4.84E-6,"-++-+++++++++++++++++-+++-+++-+-+-++-+++++++++++",37286.34]
[6.0,"AA_C_285_31345811_ML","HLA Amino Acid",3.1237832E7,"Present","Absent",0.324,0.333,1.01,0.95,-0.05129332889,0.011,4.84E-6,"-++-+++++++++++++++++-+++-+++-+-+-++-+++++++++++",37286.34]
[6.0,"SNP_C_31345989","HLA intragenic SNP",3.123801E7,"T","G",0.324,0.333,1.01,0.95,-0.05129332889,0.011,4.84E-6,"+--+-----------------+---+---+-+-+--+-----------",37286.34]
[6.0,"AA_C_267_31345989_P","HLA Amino Acid",3.123801E7,"Present","Absent",0.676,0.667,1.01,1.053,0.05164326789,0.011,4.84E-6,"+--+-----------------+---+---+-+-+--+-----------",37286.34]
[6.0,"AA_C_267_31345989_Q","HLA Amino Acid",3.123801E7,"Present","Absent",0.324,0.333,1.01,0.95,-0.05129332889,0.011,4.84E-6,"-++-+++++++++++++++++-+++-+++-+-+-++-+++++++++++",37286.34]
[6.0,"AA_C_253_31346031_Q","HLA Amino Acid",3.1238052E7,"Present","Absent",0.324,0.333,1.01,0.95,-0.05129332889,0.011,4.84E-6,"-++-+++++++++++++++++-+++-+++-+-+-++-+++++++++++",37286.34]
[6.0,"AA_C_253_31346031_E","HLA Amino Acid",3.1238052E7,"Present","Absent",0.676,0.667,1.01,1.053,0.05164326789,0.011,4.84E-6,"+--+-----------------+---+---+-+-+--+-----------",37286.34]
[6.0,"SNP_C_31346032","HLA intragenic SNP",3.1238053E7,"G","C",0.324,0.333,1.01,0.95,-0.05129332889,0.011,4.84E-6,"-++-+++++++++++++++++-+++-+++-+-+-++-+++++++++++",37286.34]
[6.0,"SNP_C_31346238_T","HLA intragenic SNP",3.1238259E7,"Present","Absent",0.676,0.667,1.01,1.053,0.05164326789,0.011,4.84E-6,"+--+-----------------+---+---+-+-+--+-----------",37286.34]
[6.0,"AA_C_184_31346238_H","HLA Amino Acid",3.1238259E7,"Present","Absent",0.676,0.667,1.01,1.053,0.05164326789,0.011,4.84E-6,"+--+-----------------+---+---+-+-+--+-----------",37286.34]
[6.0,"SNP_C_31345812_C","HLA intragenic SNP",3.1237833E7,"Present","Absent",0.676,0.667,1.01,1.053,0.05164326789,0.011,4.85E-6,"+--+-----------------+---+---+-+-+--+-----------",37286.34]
[6.0,"AA_C_184_31346238_PR","HLA Amino Acid",3.1238259E7,"Present","Absent",0.324,0.333,1.01,0.95,-0.05129332889,0.011,4.85E-6,"-++-+++++++++++++++++-+++-+++-+-+-++-+++++++++++",37286.34]
[6.0,"SNP_C_31346297","HLA intragenic SNP",3.1238318E7,"G","A",0.324,0.333,1.01,0.95,-0.05129332889,0.011,4.85E-6,"-++-+++++++++++++++++-+++-+++-+-+-++-+++++++++++",37286.34]
[6.0,"SNP_C_31346503","HLA intragenic SNP",3.1238524E7,"G","A",0.324,0.333,1.01,0.95,-0.05129332889,0.011,4.85E-6,"-++-+++++++++++++++++-+++-+++-+-+-++-+++++++++++",37286.34]
[6.0,"SNP_C_31346514","HLA intragenic SNP",3.1238535E7,"T","C",0.324,0.333,1.01,0.95,-0.05129332889,0.011,4.85E-6,"+--+-----------------+---+---+-+-+--+-----------",37286.34]
[6.0,"SNP_C_31346640","HLA intragenic SNP",3.1238661E7,"G","A",0.324,0.333,1.01,0.95,-0.05129332889,0.011,4.85E-6,"-++-+++++++++++++++++-+++-+++-+-+-++-+++++++++++",37286.34]
[6.0,"SNP_C_31346936","HLA intragenic SNP",3.1238957E7,"A","C",0.324,0.333,1.01,0.95,-0.05129332889,0.011,4.86E-6,"+--+-----------------+---+---+-+-+--+-----------",37286.34]
[6.0,"AA_C_147_31346936","HLA Amino Acid",3.1238957E7,"L","W",0.324,0.333,1.01,0.95,-0.05129332889,0.011,4.86E-6,"+--+-----------------+---+---+-+-+--+-----------",37286.34]
[6.0,"SNP_C_31346793","HLA intragenic SNP",3.1238814E7,"T","C",0.324,0.333,1.01,0.95,-0.05129332889,0.011,4.87E-6,"+--+-----------------+---+---+-+-+--+-----------",37286.34]
[6.0,"SNP_C_31347206","HLA intragenic SNP",3.1239227E7,"C","T",0.324,0.333,1.01,0.95,-0.05129332889,0.011,4.89E-6,"-++-+++++++++++++++++-+++-+++-+-+-++-+++++++++++",37286.34]
[]
["CHR, chromosome; BP, GRCh37 base-pair position; P, two-sided uncorrected p-value from an inverse variance-weighted fixed effects model meta-analysis;"]
["OR, odds ratio; SE, standard error; freq, frequency; INFO, imputation information score (average weighted by effective sample size per cohort); Neff_half, half the effective sample size;"]
["^Classical HLA alleles are named HLA_[GENE]_[ALLELE], HLA Amino Acids are named AA_[GENE]_[AMINO ACID POSITION]_[GENETIC POSITION OF CENTER OF CODON]_[ALLELE], HLA intragenic SNPs are named SNP_[GENE]_[POSITION]_[ALLELE]"]
["†For HLA Amino Acids, letters appended to the variant name or in the A1/A2 columns refer to the single letter amino acid code. G - Glycine , P – Proline, A - Alanine , V - Valine , L – Leucine, I – Isoleucine, M – Methionine, C – Cysteine, F – Phenylalanine, Y – Tyrosine, W – Tryptophan, H – Histidine, K – Lysine, R – Arginine, Q – Glutamine, N – Asparagine, E - Glutamic Acid, D - Aspartic Acid, S – Serine, T - Threonine"]
["*Direction of effect for the allele tested in each sample in the meta-analysis. + is risk increasing; - is risk decreasing; ? indicates the SNP was not present in a cohort, 0 indicates no association in either direction"]

{"sheet":"Table S8","index":8,"n_rows":12,"n_cols":15,"rows_kept":12,"cut":false,"hidden":false,"merged":[[0,0,0,12],[7,0,7,7]]}
["Supplementary Table 8. HLA variants with P < 1E-03 for association with bipolar disorder after conditioning on rs1541269."]
["CHR","Variant","Variant Type","BP","A1†","A2†","A1 freq in cases","A1 freq in controls","INFO","OR (A1 allele)","Beta (A1 allele)","SE","P","Direction*","Neff_half"]
[6.0,"AA_C_156_31346909_QDW","HLA Amino Acid",3.123893E7,"Present","Absent",0.251,0.238,1.0,1.04404,{"$f":"log(J3,2.71828)","v":0.04309783189},0.0125,5.565E-4,"+---+----+--+-----+++------+--+-----+------+-++-",37223.19]
[6.0,"AA_C_156_31346909_LR","HLA Amino Acid",3.123893E7,"Present","Absent",0.749,0.762,1.0,0.95782,-0.04309543909,0.0125,5.57E-4,"-+++-++++-++-+++++---++++++-++-+++++-++++++-+--+",37223.19]
[6.0,"AA_C_156_31346909_LRM","HLA Amino Acid",3.123893E7,"Present","Absent",0.749,0.762,1.0,0.95782,-0.04309543909,0.0125,5.57E-4,"-+++-++++-++-+++++---++++++-++-+++++-++++++-+--+",37223.19]
[6.0,"AA_C_156_31346909_LRC","HLA Amino Acid",3.123893E7,"Present","Absent",0.749,0.762,1.0,0.95782,-0.04309543909,0.0125,5.57E-4,"-+++-++++-++-+++++---++++++-++-+++++-++++++-+--+",37223.19]
[]
["CHR, chromosome; BP, GRCh37 base-pair position; P, two-sided uncorrected p-value from an inverse variance-weighted fixed effects model meta-analysis;"]
["OR, odds ratio; SE, standard error; freq, frequency; INFO, imputation information score (average weighted by effective sample size per cohort); Neff_half, half the effective sample size;"]
["^Classical HLA alleles are named HLA_[GENE]_[ALLELE], HLA Amino Acids are named AA_[GENE]_[AMINO ACID POSITION]_[GENETIC POSITION OF CENTER OF CODON]_[ALLELE], HLA intragenic SNPs are named SNP_[GENE]_[POSITION]_[ALLELE]"]
["†For HLA Amino Acids, letters appended to the variant name or in the A1/A2 columns refer to the single letter amino acid code. G - Glycine , P – Proline, A - Alanine , V - Valine , L – Leucine, I – Isoleucine, M – Methionine, C – Cysteine, F – Phenylalanine, Y – Tyrosine, W – Tryptophan, H – Histidine, K – Lysine, R – Arginine, Q – Glutamine, N – Asparagine, E - Glutamic Acid, D - Aspartic Acid, S – Serine, T - Threonine"]
["*Direction of effect for the allele tested in each sample in the meta-analysis. + is risk increasing; - is risk decreasing; ? indicates the SNP was not present in a cohort, 0 indicates no association in either direction"]

{"sheet":"Table S8_old","index":9,"n_rows":41,"n_cols":20,"rows_kept":41,"cut":false,"hidden":true,"merged":[[0,0,0,7]]}
["Supplementary Table 8. Polygenic risk score analysis results for European and non European bipolar disorder cohorts."]
["Target cohort","Target cohort ancestry ","PRS method","Target cohort N cases","Target cohort N controls","R2 % (liability scale)","P","Beta PRS on BD","N SNPs in PRS","Mix weights Finemapping*","Mix weights PRS-CS*","R2 ^(% liability scale)","95% CI ^ (R2)","p value ^ (R2)"]
["amq1","European","PRS-CS",417.0,533.0,10.032,3.0698E-32,0.865,1115457.0,"-","-",10.00393,"-","-",null,"var2","var2_perc","-1.96*(var2_perc)","1.96*(var2_perc)","95%CI: R2 liab -/+ 1.96*(var2_perc)"]
["amq1","European","Polypred-P",417.0,533.0,10.304,4.79E-33,0.878,1115457.0,0.562,0.496,10.355,"[10.271-10.439]",0.154103987148411,null,4.3E-4,{"$f":"P4*100","v":0.043},{"$f":"-1.96*Q4","v":-0.08428},{"$f":"+1.96*Q4","v":0.08428},{"$f":"concatenate(\"[\",(L4+R4),\"-\",(L4+S4),\"]\")","v":"[10.27072-10.43928]"}]
["amq1","European","SuSiE + PRS-CS",417.0,533.0,10.293,5.15E-33,0.878,1115457.0,0.668,0.5,10.338,"[10.254-10.422]",0.162435601017294,null,4.3E-4,0.043,-0.08428,0.08428,"[10.25372-10.42228]"]
["rom4","European","PRS-CS",102.0,198.0,15.015,5.3295E-15,1.176,1114738.0,"-","-",14.937,"-","-"]
["rom4","European","Polypred-P",102.0,198.0,16.81,1.5097E-16,1.269,1114738.0,1.185,0.494,16.6998,"[16.382-17.0173]",0.074957997605871,null,0.00162,{"$f":"P7*100","v":0.162},{"$f":"-1.96*Q7","v":-0.31752},{"$f":"+1.96*Q7","v":0.31752},{"$f":"concatenate(\"[\",(L7+R7),\"-\",(L7+S7),\"]\")","v":"[16.38228-17.01732]"}]
["rom4","European","SuSiE + PRS-CS",102.0,198.0,16.759,1.67E-16,1.272,1114738.0,1.39,0.51,16.6,"[16.282-16.918]",0.0893168530556103,null,0.00162,0.162,-0.31752,0.31752,"[16.28248-16.91752]"]
["for2107","European","PRS-CS",147.0,696.0,11.826,1.4898E-20,0.918,1115349.0,"-","-",12.008,"-","-"]
["for2107","European","Polypred-P",147.0,696.0,12.684,6.738E-22,0.944,1115349.0,0.679,0.308,13.07,"[12.996-13.144]",0.0849678271769769,null,3.8E-4,{"$f":"P10*100","v":0.038},{"$f":"-1.96*Q10","v":-0.07448},{"$f":"+1.96*Q10","v":0.07448},{"$f":"concatenate(\"[\",(L10+R10),\"-\",(L10+S10),\"]\")","v":"[12.99552-13.14448]"}]
["for2107","European","SuSiE + PRS-CS",147.0,696.0,12.213,3.69E-21,0.927,1115349.0,0.565,0.329,12.538,"[12.464-12.6125]",0.166677562009049,null,3.8E-4,0.038,-0.07448,0.07448,"[12.46352-12.61248]"]
["Korean","East Asian","PRS-CS",770.0,497.0,3.1,3.91E-14,0.453,959431.0,"-","-"]
["Korean","East Asian","Polypred-P",770.0,497.0,3.22,1.3E-14,0.462,959431.0,0.453,0.315]
["Korean","East Asian","SuSiE + PRS-CS",770.0,497.0,3.19,1.7E-14,0.46,959431.0,0.474,0.319]
["Japanese","East Asian","PRS-CS",2963.0,61697.0,2.343,5.65E-90,0.38,1097220.0,"-","-"]
["Japanese","East Asian","Polypred-P",2963.0,61697.0,2.61,5.19E-100,0.402,1097220.0,0.125,0.05]
["Japanese","East Asian","SuSiE + PRS-CS",2963.0,61697.0,2.608,6.6E-100,0.402,1097220.0,0.153,0.051]
["gpc_aa_om25_w1","African American","PRS-CS",445.0,690.0]
["gpc_aa_om25_w1","African American","Polypred-P",445.0,690.0,{"$nulls":11},{"$f":"D5/(D5+E5)","v":0.4389473684}]
["gpc_aa_om25_w1","African American","SuSiE + PRS-CS",445.0,690.0]
["gpc_aa_om25_w2","African American","PRS-CS",125.0,368.0]
["gpc_aa_om25_w2","African American","Polypred-P",125.0,368.0]
["gpc_aa_om25_w2","African American","SuSiE + PRS-CS",125.0,368.0]
["gpc_gsa_w1",null,"PRS-CS",923.0,1028.0]
["gpc_gsa_w1",null,"Polypred-P",923.0,1028.0]
["gpc_gsa_w1",null,"SuSiE + PRS-CS",923.0,1028.0]
["gpc_gsa_w2",null,"PRS-CS",799.0,1792.0]
["gpc_gsa_w2",null,"Polypred-P",799.0,1792.0]
["gpc_gsa_w2",null,"SuSiE + PRS-CS",799.0,1792.0]
["gpc_costarican_mega","Latinx?","PRS-CS",272.0,365.0]
["gpc_costarican_mega",null,"Polypred-P",272.0,365.0]
["gpc_costarican_mega",null,"SuSiE + PRS-CS",272.0,365.0]
["gpc_latino_gsa_w1","Latinx","PRS-CS",83.0,163.0]
["gpc_latino_gsa_w1","Latinx","Polypred-P",83.0,163.0]
["gpc_latino_gsa_w1","Latinx","SuSiE + PRS-CS",83.0,163.0]
["gpc_latino_omni25_w1","Latinx","PRS-CS",516.0,1601.0]
["gpc_latino_omni25_w1","Latinx","Polypred-P",516.0,1601.0]
["gpc_latino_omni25_w1","Latinx","SuSiE + PRS-CS",516.0,1601.0]
["R2 was calculated on the liability scale using 2% population prevalence of bipolar disorder; P value of association between polygenic risk score and bipolar disorder;"]
["*Mix weights refers to the weight assigned to the fine-mapping effect sizes and PRS-CS effect sizes by PolyPred;"]
["^ 95% CI calculated for each cohort comparing the base method (PRS-CS) against its fine-mapping informed counterparts; p values of comparison between the PRS models are one-tailed"]

{"sheet":"Table S9","index":10,"n_rows":42,"n_cols":15,"rows_kept":42,"cut":false,"hidden":false,"merged":[[0,0,0,13]]}
["Supplementary Table 9. Polygenic risk score analysis results for European and non European bipolar disorder cohorts."]
["Target cohort","Target cohort ancestry ","PRS method","Target cohort N cases","Target cohort N controls","N SNPs in PRS","Mix weights Fine-mapping*","Mix weights PRS-CS*","Beta PRS on BD","R2 (% liability scale)†","Lower 95% CI†","Upper 95% CI†","P†","P Fine-mapping-informed PRS vs. PRS-CS^ ","R2 difference Fine-mapping-informed PRS - PRS-CS (% liability scale)"]
["amq1","European","PRS-CS",417.0,533.0,1115457.0,"-","-",0.865,10.07261,10.004,10.141,3.07E-32,"-","-"]
["amq1","European","Polypred-P",417.0,533.0,7481595.0,0.337277574885365,0.442608211160865,0.898,10.73076,10.658,10.803,3.61E-34,0.0676925361674055,{"$f":"J4-J3","v":0.65815}]
["amq1","European","SuSiE + PRS-CS",417.0,533.0,7481595.0,0.26106733101648,0.515960840209055,0.886,10.39098,10.321,10.461,2.6E-33,0.151942300568479,{"$f":"J5-J3","v":0.31837}]
["rom4","European","PRS-CS",102.0,198.0,1114738.0,"-","-",1.176,14.97403,14.668,15.28,5.33E-15,"-","-"]
["rom4","European","Polypred-P",102.0,198.0,7431243.0,0.439042721655833,0.467078996156869,1.245,16.50823,16.18,16.836,3.58E-16,0.0984006985967978,{"$f":"J7-J6","v":1.5342}]
["rom4","European","SuSiE + PRS-CS",102.0,198.0,7431243.0,0.341563657251353,0.50492250829242,1.219,15.76461,15.447,16.082,1.23E-15,0.185554983415074,{"$f":"J8-J6","v":0.79058}]
["for2107","European","PRS-CS",147.0,696.0,1115349.0,"-","-",0.918,12.05076,11.952,12.149,1.49E-20,"-","-"]
["for2107","European","Polypred-P",147.0,696.0,7480104.0,0.159245063329181,0.317131056411459,0.935,12.46219,12.361,12.564,3.66E-21,0.195863278908612,{"$f":"J10-J9","v":0.41143}]
["for2107","European","SuSiE + PRS-CS",147.0,696.0,7480104.0,0.110319843883044,0.334293275741154,0.926,12.23978,12.14,12.34,7.75E-21,0.277932566089461,{"$f":"J11-J9","v":0.18902}]
["Korean","East Asian","PRS-CS",770.0,497.0,959431.0,"-","-",0.47295,3.366,3.346,3.385,3.5825E-15,"-","-"]
["Korean","East Asian","Polypred-P",770.0,497.0,5069674.0,0.20984,0.31101,0.48613,3.554,3.534,3.575,6.463E-16,0.35,{"$f":"J13-J12","v":0.188}]
["Korean","East Asian","SuSiE + PRS-CS",770.0,497.0,5069674.0,0.19672,0.31613,0.48381,3.517,3.496,3.537,8.9786E-16,0.403,{"$f":"J14-J12","v":0.151}]
["Japanese","East Asian","PRS-CS",2936.0,61724.0,1097220.0,"-","-",0.3786964,2.284815,2.2847,2.2849,3.31E-88,"-","-"]
["Japanese","East Asian","Polypred-P",2936.0,61724.0,7155360.0,0.0627,0.0445,0.4129783,2.739185,2.7391,2.74,1.06E-104,2.28E-6,{"$f":"J16-J15","v":0.45437}]
["Japanese","East Asian","SuSiE + PRS-CS",2936.0,61724.0,7155360.0,0.0612,0.0455,0.4084671,2.67504,2.6749,2.6751,1.9E-102,1.22E-5,{"$f":"J17-J15","v":0.390225}]
["gpc_aa_om25_w1","African American","PRS-CS",445.0,690.0,1049105.0,"-","-",0.41069822,0.423,0.41978697,0.42599518,4.29E-6,"-","-"]
["gpc_aa_om25_w1","African American","Polypred-P",445.0,690.0,5674035.0,3.08351722,0.5615235,0.2002512,0.571,0.56744039,0.57566227,0.00156587,0.71206569,{"$f":"J19-J18","v":0.148}]
["gpc_aa_om25_w1","African American","SuSiE + PRS-CS",445.0,690.0,5674035.0,3.000205,0.54653057,0.2260823,0.702,0.69788044,0.70787189,3.9148E-4,0.50766364,{"$f":"J20-J18","v":0.279}]
["gpc_aa_om25_w2","African American","PRS-CS",125.0,368.0,1049105.0,"-","-",0.40692307,0.732,0.7196715,0.74545768,0.00784004,"-","-"]
["gpc_aa_om25_w2","African American","Polypred-P",125.0,368.0,5674035.0,2.63271121,0.53782178,0.1772533,0.247,0.24190696,0.25251412,0.13494651,0.613693378,{"$f":"J22-J21","v":-0.485}]
["gpc_aa_om25_w2","African American","SuSiE + PRS-CS",125.0,368.0,5674035.0,1.21488388,0.32823059,0.08233936,0.022,0.02028212,0.0237736,0.51891543,0.370595591,{"$f":"J23-J21","v":-0.71}]
["gpc_aa_gsa_w1","African American","PRS-CS",923.0,1028.0,1049105.0,"-","-",0.12284059,0.014,0.01466402,0.01491818,0.07868834,"-","-"]
["gpc_aa_gsa_w1","African American","Polypred-P",923.0,1028.0,5674035.0,1.08075132,1.01219459,0.01987974,0.0575,0.05718943,0.05778601,0.14795392,0.35658524,{"$f":"J25-J24","v":0.0435}]
["gpc_aa_gsa_w1","African American","SuSiE + PRS-CS",923.0,1028.0,5674035.0,0.64871386,1.09803345,0.14466807,0.036,0.03604421,0.0364706,0.03072622,0.41773623,{"$f":"J26-J24","v":0.022}]
["gpc_aa_gsa_w2","African American","PRS-CS",799.0,1792.0,1049105.0,"-","-",0.19984732,0.021,0.02166594,0.02188734,0.0031878,"-","-"]
["gpc_aa_gsa_w2","African American","Polypred-P",799.0,1792.0,5674035.0,0.2319561,0.31756976,0.18552204,0.479,0.47797441,0.48094147,2.65E-5,0.04384416,{"$f":"J28-J27","v":0.458}]
["gpc_aa_gsa_w2","African American","SuSiE + PRS-CS",799.0,1792.0,5674035.0,0.3561941,0.00414807,0.19544793,0.503,0.50240966,0.50552258,1.08E-5,0.035117439,{"$f":"J29-J27","v":0.482}]
["gpc_costarican_mega","Latino","PRS-CS",272.0,365.0,1049105.0,"-","-",0.81213399,0.122,0.12266882,0.12267921,1.5E-17,"-","-"]
["gpc_costarican_mega","Latino","Polypred-P",272.0,365.0,5674035.0,1.6502337,0.42156928,0.90185717,0.961,0.95168395,0.97148881,1.86E-22,0.00206919,{"$f":"J31-J30","v":0.839}]
["gpc_costarican_mega","Latino","SuSiE + PRS-CS",272.0,365.0,5674035.0,1.43648646,0.50170555,0.84495939,0.11270898,0.11270623,0.11271174,1.34E-20,0.04619313,{"$f":"J32-J30","v":-0.00929102}]
["gpc_latino_gsa_w1","Latino","PRS-CS",83.0,163.0,1049105.0,"-","-",0.53276659,0.429,0.42860846,0.43074976,0.00290443,"-","-"]
["gpc_latino_gsa_w1","Latino","Polypred-P",83.0,163.0,5674035.0,1.57991895,0.50829793,0.56525965,0.257,0.24855269,0.26508238,3.6747E-4,0.158826,{"$f":"J34-J33","v":-0.172}]
["gpc_latino_gsa_w1","Latino","SuSiE + PRS-CS",83.0,163.0,5674035.0,0.99001449,0.37340367,0.55902655,0.29645,0.2962104,0.29670866,6.5091E-4,0.220813717,{"$f":"J35-J33","v":-0.13255}]
["gpc_latino_omni25_w1","Latino","PRS-CS",516.0,1601.0,1049105.0,"-","-",0.52615703,0.35997,0.35994245,0.35999899,3.46E-18,"-","-"]
["gpc_latino_omni25_w1","Latino","Polypred-P",516.0,1601.0,5674035.0,1.91469384,0.75801984,0.53615862,0.3145,0.31450135,0.31458291,3.26E-18,0.25121196,{"$f":"J37-J36","v":-0.04547}]
["gpc_latino_omni25_w1","Latino","SuSiE + PRS-CS",516.0,1601.0,5674035.0,2.98771758,0.60571887,0.52615862,0.35996,0.35993684,0.35999337,3.46E-18,0.24001196,{"$f":"J38-J36","v":-0.00001}]
[]
["*Mix weights refers to the weight assigned to the fine-mapping PRS and the PRS-CS PRS by PolyPred;"]
["†R2, 95% confidence intervals (CI) and P value of association between PRS and bipolar disorder vs. control status in the target cohort were calculated using the r2redux package. The R2 was calculated on the liability scale using 2% population prevalence of bipolar disorder; "]
["^P value of comparison between R2 from SuSiE+PRS-CS vs. PRS-CS or PolyPred-P vs. PRS-CS were calculated using r2redux package. These P values are one-tailed."]