Targeting apoptosis signaling in pancreatic cancer
- The ability to escape apoptosis or programmed cell death is a hallmark of human cancers, for example pancreatic cancer. This can promote tumorigenesis, since too little cell death by apoptosis disturbs tissue homeostasis. Additionally, defective apoptosis signaling is the underlying cause of failure to respond to current treatment approaches, since therapy-mediated antitumor activity requires the intactness of apoptosis signaling pathways in cancer cells. Thus, the elucidation of defects in the regulation of apoptosis in pancreatic carcinoma can result in the identification of novel targets for therapeutic interference and for exploitation for cancer drug discovery. Keywords: apoptosis; pancreatic cancer; TRAIL; IAPs; mitochondria
Download full text files
Additional Services
| Author: | Simone FuldaORCiDGND |
|---|---|
| URN: | urn:nbn:de:hebis:30-100343 |
| DOI: | https://doi.org/doi:10.3390/cancers3010241 |
| ISSN: | 2072-6694 |
| Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/24212616 |
| Parent Title (English): | Cancers |
| Publisher: | MDPI |
| Place of publication: | Basel |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2011/08/08 |
| Date of first Publication: | 2011/01/11 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2011/08/08 |
| Tag: | IAPs; TRAIL; apoptosis; mitochondria; pancreatic cancer |
| Volume: | 3 |
| Issue: | 1 |
| Page Number: | 11 |
| First Page: | 241 |
| Last Page: | 251 |
| Note: | © 2011 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
| HeBIS-PPN: | 272541575 |
| Institutes: | Medizin / Medizin |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - Namensnennung 3.0 |
