Orthotopic liver transplantation in human-immunodeficiency-virus-positive patients in Germany

  • Objectives: This summary evaluates the outcomes of orthotopic liver transplantation (OLT) of HIV-positive patients in Germany. Methods: Retrospective chart analysis of HIV-positive patients, who had been liver-transplanted in Germany between July 1997 and July 2011. Results: 38 transplantations were performed in 32 patients at 9 German transplant centres. The reasons for OLT were end-stage liver disease (ESLD) and/or liver failure due to hepatitis C (HCV) (n = 19), hepatitis B (HBV) (n = 10), multiple viral infections of the liver (n = 2) and Budd-Chiari-Syndrome. In July 2011 19/32 (60%) of the transplanted patients were still alive with a median survival of 61 months (IQR (interquartile range): 41-86 months). 6 patients had died in the early post-transplantation period from septicaemia (n = 4), primary graft dysfunction (n = 1), and intrathoracal hemorrhage (n = 1). Later on 7 patients had died from septicaemia (n = 2), delayed graft failure (n = 2), recurrent HCC (n = 2), and renal failure (n = 1). Recurrent HBV infection was efficiently prevented in 11/12 patients; HCV reinfection occurred in all patients and contributed considerably to the overall mortality. Conclusions: Overall OLT is a feasible approach in HIV-infected patients with acceptable survival rates in Germany. Reinfection with HCV still remains a major clinical challenge in HIV/HCV coinfection after OLT.

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Author:Evrim Anadol, Susanne Beckebaum, Klaus Radecke, Andreas Paul, Alexander Zoufaly, Markus Bickel, Florian Hitzenbichler, Tom M. Ganten, Jens Martin Kittner, Matthias Stoll, C. Berg, Steffen Manekeller, Jörg C. Kalff, Tilman Sauerbruch, Jürgen Rockstroh, Ulrich Spengler
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/22900154
Parent Title (English):AIDS research and treatment
Place of publication:New York, NY
Document Type:Article
Date of Publication (online):2012/07/30
Date of first Publication:2012/07/30
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2012/10/12
Issue:Article ID 197501
Page Number:9
Copyright © 2012 E. Anadol et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 3.0