Involvement of the oncogene B-cell lymphoma 6 in the fusion and differentiation process of trophoblastic cells of the placenta

  • The oncogene B-cell lymphoma 6 (BCL6) is associated with lymphomagenesis. Intriguingly, its expression is increased in preeclamptic placentas. Preeclampsia is one of the leading causes of maternal and perinatal mortality and morbidity. Preeclamptic placentas are characterized by various defects like deregulated differentiation and impaired fusion of trophoblasts. Its pathogenesis is however not totally understood. We show here that BCL6 is present throughout the cell fusion process in the fusogenic trophoblastic cell line BeWo. Suppression of BCL6 promotes trophoblast fusion, indicated by enhanced levels of fusion-related β-hCG, syncytin 1 and syncytin 2. Increased mRNA levels of these genes could also be observed in primary term cytotrophoblasts depleted of BCL6. Conversely, stable overexpression of BCL6 reduces the fusion capacity of BeWo cells. These data suggest that an accurately regulated expression of BCL6 is important for proper differentiation and successful syncytialization of trophoblasts. While deregulated BCL6 is linked to lymphomagenesis by blocking lymphocyte terminal differentiation, increased BCL6 in the placenta contributes to the development of preeclampsia by impairing trophoblast differentiation and fusion.

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Author:Britta Jasmer, Cornelia Muschol-Steinmetz, Nina-Naomi Kreis, Alexandra Friemel, Ulrikke Kielland-Kaisen, Dörthe BrüggmannORCiDGND, Lukas JenneweinORCiDGND, Roman Allert, Christine Solbach, Juping Yuan, Frank LouwenGND
URN:urn:nbn:de:hebis:30:3-322783
DOI:https://doi.org/10.18632/oncotarget.20586
ISSN:1949-2553
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/29312557
Parent Title (English):OncoTarget
Publisher:Impact Journals LLC
Place of publication:[s. l.]
Document Type:Article
Language:English
Year of Completion:2017
Date of first Publication:2017/08/24
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2013/11/13
Tag:BCL6; cell fusion; differentiation; preeclampsia; trophoblast
Volume:8
Issue:65
Page Number:12
First Page:108643
Last Page:108654
Note:
Copyright: Jasmer et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
HeBIS-PPN:450643611
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Open-Access-Publikationsfonds:Medizin
Licence (German):License LogoCreative Commons - Namensnennung 3.0