Targeting GLI transcription factors in cancer

  • Aberrant activation of hedgehog (Hh) signaling has been observed in a wide variety of tumors and accounts for more than 25% of human cancer deaths. Inhibitors targeting the Hh signal transducer Smoothened (SMO) are widely used and display a good initial efficacy in patients suffering from basal cell carcinoma (BCC); however, a large number of patients relapse. Though SMO mutations may explain acquired therapy resistance, a growing body of evidence suggests that the non-canonical, SMO-independent activation of the Hh pathway in BCC patients can also account for this adverse effect. In this review, we highlight the importance of glioma-associated oncogene (GLI) transcription factors (the main downstream effectors of the canonical and the non-canonical Hh cascade) and their putative role in the regulation of multiple oncogenic signaling pathways. Moreover, we discuss the contribution of the Hh signaling to malignant transformation and propose GLIs as central hubs in tumor signaling networks and thus attractive molecular targets in anti-cancer therapies.

Download full text files

Export metadata

Author:Miroslava Didiasova, Liliana Schäfer, Malgorzata Wygrecka
Pubmed Id:
Parent Title (English):Molecules
Place of publication:Basel
Contributor(s):Takaomi Sanda
Document Type:Article
Year of Completion:2018
Date of first Publication:2018/04/24
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2018/10/02
Tag:GLI inhibitors; cancer; cancer stem cells; glioma-associated oncogene homolog; hedgehog signaling
Issue:5, Art. 1003
Page Number:19
First Page:1
Last Page:19
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0