Endothelial to mesenchymal transition in cardiovascular disease : JACC state-of-the-art review

  • Endothelial to mesenchymal transition (EndMT) is a process whereby an endothelial cell undergoes a series of molecular events that lead to a change in phenotype toward a mesenchymal cell (e.g., myofibroblast, smooth muscle cell). EndMT plays a fundamental role during development, and mounting evidence indicates that EndMT is involved in adult cardiovascular diseases (CVDs), including atherosclerosis, pulmonary hypertension, valvular disease, and fibroelastosis. Therefore, the targeting of EndMT may hold therapeutic promise for treating CVD. However, the field faces a number of challenges, including the lack of a precise functional and molecular definition, a lack of understanding of the causative pathological role of EndMT in CVDs (versus being a “bystander-phenomenon”), and a lack of robust human data corroborating the extent and causality of EndMT in adult CVDs. Here, we review this emerging but exciting field, and propose a framework for its systematic advancement at the molecular and translational levels.

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Author:Jason C. Kovacic, Stefanie DimmelerORCiDGND, Richard P. Harvey, Toren Finkel, Elena Aikawa, Guido Krenning, Andrew H. Baker
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/30654892
Parent Title (English):Journal of the American College of Cardiology
Publisher:Elsevier ; American College of Cardiology
Place of publication:New York, NY
Document Type:Article
Year of Completion:2019
Date of first Publication:2019/01/14
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2019/01/24
Tag:EndMT; cardiovascular; endothelial to mesenchymal transition
Page Number:20
First Page:190
Last Page:209
© 2019 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Institutes:Medizin / Medizin
Exzellenzcluster / Exzellenzcluster Makromolekulare Komplexe
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0