Sarcopenia as a prognostic factor for survival in patients with locally advanced gastroesophageal adenocarcinoma

  • Background and aims: Patients with gastric cancer often show signs of malnutrition. We sought to evaluate the influence of sarcopenia in patients with locally advanced, not metastasized, gastric or gastro-esophageal junction (GEJ) cancer undergoing curative treatment (perioperative chemotherapy and surgery) on morbidity and mortality in order to identify patients in need for nutritional intervention. Patients and methods: Two-centre study, conducted in the Frankfurt University Clinic and Krankenhaus Nordwest (Frankfurt) as part of the University Cancer Center Frankfurt (UCT). 47/83 patients were treated in the FLOT trial (NCT01216644). Patients´ charts were reviewed for clinical data. Two consecutive CT scans were retrospectively analyzed to determine the degree of sarcopenia. Survival was calculated using the Kaplan-Meier method, multivariate analysis was performed using the Cox regression. Results: 60 patients (72.3%) were male and 23 (27.7%) female. 45 patients (54.2%) had GEJ type 1–3 and 38 (45.8%) gastric tumors, respectively. Sarcopenic patients were significantly older than non-sarcopenic patients (mean age 65.1 years vs. 59.5 years, p = 0.042), terminated the chemotherapy significantly earlier (50% vs. 22.6%, p = 0.037) and showed higher Clavien-Dindo scores, indicating more severe perioperative complications (score ≥3 43.3 vs. 17.0%, p = 0.019). Sarcopenic patients had a significantly shorter survival than non-sarcopenic patients (139.6 ± 19.5 [95% CI, 101.3–177.9] vs. 206.7 ± 13.8 [95% CI, 179.5–233.8] weeks, p = 0.004). Multivariate Cox regression analysis showed that, besides UICC stage, sarcopenia significantly influenced survival. Conclusion: Sarcopenia is present in a large proportion of patients with locally advanced gastric or GEJ cancer and significantly influences tolerability of chemotherapy, surgical complications and survival.

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Author:Christine Koch, Cornelius Reitz, Teresa Schreckenbach, Katrin Eichler, Natalie Filmann, Salah-Eddin al- Batran, Thorsten Götze, Stefan ZeuzemORCiDGND, Wolf Otto Bechstein, Thomas Kraus, Jörg BojungaGND, Markus Düx, Jörg Trojan, Irina Ursula Blumenstein
URN:urn:nbn:de:hebis:30:3-513934
DOI:https://doi.org/10.1371/journal.pone.0223613
ISSN:1932-6203
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/31639132
Parent Title (English):PLoS one
Publisher:PLoS
Place of publication:Lawrence, Kan.
Contributor(s):Ramon Andrade de Mello
Document Type:Article
Language:English
Year of Completion:2019
Date of first Publication:2019/10/22
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2019/10/23
Tag:Cancer chemotherapy; Cancer treatment; Digestive system procedures; Gastric cancer; Regression analysis; Sarcopenia; Surgical and invasive medical procedures; Surgical oncology
Volume:14
Issue:(10): e0223613
Page Number:11
First Page:1
Last Page:11
Note:
Copyright: © 2019 Koch et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
HeBIS-PPN:455389519
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Open-Access-Publikationsfonds:Medizin
Licence (German):License LogoCreative Commons - Namensnennung 4.0