The effect of 10 Hz transcranial alternating current stimulation (tACS) on corticomuscular coherence

  • Synchronous oscillatory activity at alpha (8–12 Hz), beta (13–30 Hz), and gamma (30–90 Hz) frequencies is assumed to play a key role for motor control. Corticomuscular coherence (CMC) represents an established measure of the pyramidal system's integrity. Transcranial alternating current stimulation (tACS) offers the possibility to modulate ongoing oscillatory activity. Behaviorally, 20 Hz tACS in healthy subjects has been shown to result in movement slowing. However, the neurophysiological changes underlying these effects are not entirely understood yet. The present study aimed at ascertaining the effects of tACS at 10 and 20 Hz in healthy subjects on CMC and local power of the primary sensorimotor cortex. Neuromagnetic activity was recorded during isometric contraction before and at two time points (2–10 min and 30–38 min) after tACS of the left primary motor cortex (M1), using a 306 channel whole head magnetoencephalography (MEG) system. Additionally, electromyography (EMG) of the right extensor digitorum communis (EDC) muscle was measured. TACS was applied at 10 and 20 Hz, respectively, for 10 min at 1 mA. Sham stimulation served as control condition. The data suggest that 10 Hz tACS significantly reduced low gamma band CMC during isometric contraction. This implies that tACS does not necessarily cause effects at stimulation frequency. Rather, the findings suggest cross-frequency interplay between alpha and low gamma band activity modulating functional interaction between motor cortex and muscle.

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Author:Claudia Wach, Vanessa Krause, Vera Moliadze, Walter Paulus, Alfons Schnitzler, Bettina Pollok
Pubmed Id:
Parent Title (English):Frontiers in human neuroscience
Publisher:Frontiers Research Foundation
Place of publication:Lausanne
Contributor(s):Ulf Ziemann
Document Type:Article
Year of Completion:2013
Date of first Publication:2013/08/29
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2019/11/04
Tag:corticomuscular coherence (CMC); magnetoencephalography (MEG); motor control; primary motor cortex (M1); transcranial alternating current stimulation (tACS)
Issue:Art. 511
Page Number:10
First Page:1
Last Page:10
Copyright © 2013 Wach, Krause, Moliadze, Paulus, Schnitzler and Pollok. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 3.0