Nora Maria Raschle, Willeke Martine Menks, Lynn Valérie Fehlbaum, Martin Steppan, Areti Smaragdi, Karen Gonzalez-Madruga, Jack C. Rogers, Roberta Clanton, Gregor Kohls, Anne Martinelli, Anka Bernhard, Kerstin Konrad, Beate Herpertz-Dahlmann, Christine M. Freitag, Graeme Fairchild, Stéphane A. De Brito, Christina Stadler
- Callous-unemotional traits are characterized by a lack of empathy, a disregard for others' feelings and shallow or deficient affect, such as a lack of remorse or guilt. Neuroanatomical correlates of callous-unemotional traits have been demonstrated in clinical samples (i.e., adolescents with disruptive behavior disorders). However, it is unknown whether callous-unemotional traits are associated with neuroanatomical correlates within normative populations without clinical levels of aggression or antisocial behavior. Here we investigated the relationship between callous-unemotional traits and gray matter volume using voxel-based morphometry in a large sample of typically-developing boys and girls (N = 189). Whole-brain multiple regression analyses controlling for site, total intracranial volume, and age were conducted in the whole sample and in boys and girls individually. Results revealed that sex and callous-unemotional traits interacted to predict gray matter volume when considering the whole sample. This interaction was driven by a significant positive correlation between callous-unemotional traits and bilateral anterior insula volume in boys, but not girls. Insula gray matter volume explained 19% of the variance in callous-unemotional traits for boys. Our results demonstrate that callous-unemotional traits are related to variations in brain structure beyond psychiatric samples. This association was observed for boys only, underlining the importance of considering sex as a factor in future research designs. Future longitudinal studies should determine whether these findings hold over childhood and adolescence, and whether the neuroanatomical correlates of callous-unemotional traits are predictive of future psychiatric vulnerability.
MetadatenAuthor: | Nora Maria RaschleORCiDGND, Willeke Martine Menks, Lynn Valérie Fehlbaum, Martin Steppan, Areti SmaragdiORCiD, Karen Gonzalez-MadrugaORCiD, Jack C. RogersORCiDGND, Roberta Clanton, Gregor KohlsORCiDGND, Anne MartinelliORCiDGND, Anka BernhardGND, Kerstin KonradORCiDGND, Beate Herpertz-DahlmannORCiDGND, Christine M. FreitagORCiDGND, Graeme FairchildORCiD, Stéphane A. De BritoORCiD, Christina StadlerORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-542840 |
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DOI: | https://doi.org/10.1016/j.nicl.2017.12.015 |
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ISSN: | 2213-1582 |
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Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/29527490 |
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Parent Title (English): | NeuroImage: Clinical |
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Publisher: | Elsevier |
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Place of publication: | [Amsterdam u. a.] |
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Document Type: | Article |
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Language: | English |
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Year of Completion: | 2017 |
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Date of first Publication: | 2017/12/09 |
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Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Release Date: | 2020/07/22 |
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Tag: | Callous-unemotional traits; Insula; Pediatric neuroimaging; Sex differences; Voxel-based morphometry |
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Volume: | 17 |
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Page Number: | 9 |
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First Page: | 856 |
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Last Page: | 864 |
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Note: | Under a Creative Commons license |
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HeBIS-PPN: | 467516901 |
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Institutes: | Medizin / Medizin |
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Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Licence (German): | Creative Commons - Namensnennung-Nicht kommerziell - Keine Bearbeitung 4.0 |
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