Rab27a contributes to the processing of inflammatory pain in mice

  • Tissue injury and inflammation may result in chronic pain, a severe debilitating disease that is associated with great impairment of quality of life. An increasing body of evidence indicates that members of the Rab family of small GTPases contribute to pain processing; however, their specific functions remain poorly understood. Here, we found using immunofluorescence staining and in situ hybridization that the small GTPase Rab27a is highly expressed in sensory neurons and in the superficial dorsal horn of the spinal cord of mice. Rab27a mutant mice, which carry a single-nucleotide missense mutation of Rab27a leading to the expression of a nonfunctional protein, show reduced mechanical hyperalgesia and spontaneous pain behavior in inflammatory pain models, while their responses to acute noxious mechanical and thermal stimuli is not affected. Our study uncovers a previously unrecognized function of Rab27a in the processing of persistent inflammatory pain in mice.

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Author:Tilman Gross, Gesine Wack, Katharina Martina Janice Syhr, Tanya Tolmachova, Miguel C. Seabra, Gerd GeisslingerORCiDGND, Ellen Niederberger, Achim Schmidtko, Wiebke Kallenborn-Gerhardt
URN:urn:nbn:de:hebis:30:3-554390
DOI:https://doi.org/10.3390/cells9061488
ISSN:2073-4409
Parent Title (English):Cells
Publisher:MDPI
Place of publication:Basel
Document Type:Article
Language:English
Date of Publication (online):2020/06/18
Date of first Publication:2020/06/18
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2020/08/14
Tag:Rab27a; dorsal root ganglia; inflammatory pain; mice; spinal cord
Volume:9
Issue:6, art. 1488
Page Number:16
First Page:1
Last Page:16
Note:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
HeBIS-PPN:469521724
Institutes:Biochemie, Chemie und Pharmazie
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
Sammlungen:Universitätspublikationen
Open-Access-Publikationsfonds:Biochemie, Chemie und Pharmazie
Licence (German):License LogoCreative Commons - Namensnennung 4.0