Severe traumatic brain injury (TBI) modulates the kinetic profile of the inflammatory response of markers for neuronal damage

  • The inflammatory response plays an important role in the pathophysiology of multiple injuries. This study examines the effects of severe trauma and inflammatory response on markers of neuronal damage. A retrospective analysis of prospectively collected data in 445 trauma patients (Injury Severity Score (ISS) ≥ 16) is provided. Levels of neuronal biomarkers (calcium-binding Protein B (S100b), Enolase2 (NSE), glial fibrillary acidic protein (GFAP)) and Interleukins (IL-6, IL-10) in severely injured patients (with polytrauma (PT)) without traumatic brain injury (TBI) or with severe TBI (PT+TBI) and patients with isolated TBI (isTBI) were measured upon arrival until day 5. S100b, NSE, GFAP levels showed a time-dependent decrease in all cohorts. Their expression was higher after multiple injuries (p = 0.038) comparing isTBI. Positive correlation of marker level after concomitant TBI and isTBI (p = 0.001) was noted, while marker expression after PT appears to be independent. Highest levels of IL-6 and -10 were associated to PT und lowest to isTBI (p < 0.001). In all groups pro-inflammatory response (IL-6/-10 ratio) peaked on day 2 and at a lower level on day 4. Severe TBI modulates kinetic profile of inflammatory response by reducing interleukin expression following trauma. Potential markers for neuronal damage have a limited diagnostic value after severe trauma because undifferentiated increase.

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Author:Cora Rebecca SchindlerORCiDGND, Thomas LustenbergerORCiDGND, Mathias Woschek, Philipp StörmannORCiDGND, Dirk HenrichORCiDGND, Peter Radermacher, Ingo MarziORCiDGND
URN:urn:nbn:de:hebis:30:3-555762
DOI:https://doi.org/10.3390/jcm9061667
ISSN:2077-0383
Parent Title (English):Journal of Clinical Medicine
Publisher:MDPI
Place of publication:Basel
Document Type:Article
Language:English
Date of Publication (online):2020/06/01
Date of first Publication:2020/06/01
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2020/09/23
Tag:GFAP; IL-10; IL-6; NSE; S100b; biomarker; multiple trauma; posttraumatic inflammation; risk prediction; traumatic brain injury (TBI)
Volume:9
Issue:(6), article 1667
Page Number:13
HeBIS-PPN:470773847
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - Namensnennung 4.0