Immunohistochemistry for prostate biopsy - impact on histological prostate cancer diagnoses and clinical decision making

  • Background: To test the value of immunohistochemistry (IHC) staining in prostate biopsies for changes in biopsy results and its impact on treatment decision-making. Methods: Between January 2017–June 2020, all patients undergoing prostate biopsies were identified and evaluated regarding additional IHC staining for diagnostic purpose. Final pathologic results after radical prostatectomy (RP) were analyzed regarding the effect of IHC at biopsy. Results: Of 606 biopsies, 350 (58.7%) received additional IHC staining. Of those, prostate cancer (PCa) was found in 208 patients (59.4%); while in 142 patients (40.6%), PCa could be ruled out through IHC. IHC patients harbored significantly more often Gleason 6 in biopsy (p < 0.01) and less suspicious baseline characteristics than patients without IHC. Of 185 patients with positive IHC and PCa detection, IHC led to a change in biopsy results in 81 (43.8%) patients. Of these patients with changes in biopsy results due to IHC, 42 (51.9%) underwent RP with 59.5% harboring ≥pT3 and/or Gleason 7–10. Conclusions: Patients with IHC stains had less suspicious characteristics than patients without IHC. Moreover, in patients with positive IHC and PCa detection, a change in biopsy results was observed in >40%. Patients with changes in biopsy results partly underwent RP, in which 60% harbored significant PCa.

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Author:Philipp MandelORCiDGND, Mike WenzelORCiDGND, Robert Benedikt HöhORCiDGND, Maria-Noemi WelteGND, Felix Martin PreißerORCiDGND, Tahir Inam, Clarissa Wittler, Clara Julia HumkeGND, Jens KöllermannORCiDGND, Peter Johannes WildORCiDGND, Christoph WürnschimmelORCiD, Derya TilkiORCiDGND, Markus Graefen, Luis KluthORCiDGND, Pierre I. Karakiewicz, Felix ChunORCiDGND, Andreas Becker
Parent Title (English):Current oncology
Place of publication:Basel
Document Type:Article
Date of Publication (online):2021/06/09
Date of first Publication:2021/06/09
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2021/07/26
Tag:ASAP; Gleason Score; IHC; immunohistochemistry; prostate cancer; radical prostatectomy
Page Number:11
First Page:2123
Last Page:2133
Institutes:Medizin / Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0