An inventory of lysosomal ABC transporters

  • ABC transporters fulfill diverse physiological functions in different cellularlocalizations ranging from the plasma membrane to intracellular membranouscompartments. Several ABC transporters have been spotted in the endolyso-somal system, which consists of endosomes, autophagosomes, lysosomes, andlysosome-related organelles. In this review, we present an overview of lysoso-mal ABC transporters including ABCA2, ABCA3, ABCA5, ABCB6,ABCB9, and ABCD4, discussing their trafficking routes, putative substrates,potential physiological functions, and associated diseases. In addition, weoffer a critical evaluation of the literature linking ABC transporters to lyso-somal drug sequestration, examining pitfalls associated with in vitro modelsof drug resistance.

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Author:Gergely Szakacs, Rupert Abele
Parent Title (English):FEBS letters : for the rapid publication of short reports in biochemistry, biophysics, and molecular biology
Place of publication:Chichester
Document Type:Article
Date of Publication (online):2020/10/24
Date of first Publication:2020/10/24
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2021/07/21
Tag:ABC transporters; cholesterol; drug resistance; endolysosomal system; lipid; lysosomes; peptide transport; surfactant; trafficking; vitamin B12
Page Number:21
First Page:3965
Last Page:3985
Institutes:Biochemie, Chemie und Pharmazie
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0