Regulation of long non-coding RNAs by statins in atherosclerosis

  • Despite increased public health awareness, atherosclerosis remains a leading cause of mortality worldwide. Significant variations in response to statin treatment have been noted among different populations suggesting that the efficacy of statins may be altered by both genetic and environmental factors. The existing literature suggests that certain long noncoding RNAs (lncRNAs) might be up- or downregulated among patients with atherosclerosis. LncRNA may act on multiple levels (cholesterol homeostasis, vascular inflammation, and plaque destabilization) and exert atheroprotective or atherogenic effects. To date, only a few studies have investigated the interplay between statins and lncRNAs known to be implicated in atherosclerosis. The current review characterizes the role of lncRNAs in atherosclerosis and summarizes the available evidence related to the effect of statins in regulating lncRNAs.

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Author:Diamantis I. TsilimigrasORCiD, Sofia Iris BibliORCiD, Gerasimos Siasos, Evangelos OikonomouORCiD, Despina N. Perrea, Konstantinos FilisORCiD, Dimitrios Tousoulis, Fragiska Sigala
Parent Title (English):Biomolecules
Place of publication:Basel
Document Type:Article
Date of Publication (online):2021/04/22
Date of first Publication:2021/04/22
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2021/10/06
Tag:RNA; epigenetics; statin; vascular biology
Issue:5, art. 623
Page Number:14
First Page:1
Last Page:14
This research work was supported by the Onassis Foundation—Scholarship ID: G ZO 030-1/2018-2019.
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0