The influence of modified experimental dental resin composites on the initial in situ biofilm - a triple-blinded, randomized, controlled split-mouth trial

  • The purpose of the study was to investigate the bacterial viability of the initial biofilm on the surface of experimental modified dental resin composites. Twenty-five healthy individuals with good oral hygiene were included in this study. In a split-mouth design, they received acrylic splints with five experimental composite resin specimens. Four of them were modified with either a novel polymeric hollow-bead delivery system or methacrylated polymerizable Irgasan (Antibacterial B), while one specimen served as an unmodified control (ST). A delivery system based on Poly-Pore® was loaded with one of the active agents: Tego® Protect 5000 (Antiadhesive A), Dimethicone (Antiadhesive B), or Irgasan (Antibacterial A). All study subjects refrained from toothbrushing during the study period. Specimens were detached from the splints after 8 h and given a live/dead staining before fluorescence microscopy. A Friedman test and a post hoc Nemenyi test were applied with a significance level at p < 0.05. In summary, all materials but Antibacterial B showed a significant antibacterial effect compared to ST. The results suggested the role of the materials’ chemistry in the dominance of cell adhesion. In conclusion, dental resin composites with Poly-Pore-loaded active agents showed antibacterial effectiveness in situ.

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Author:Niklas BurgardORCiD, Melanie Kienitz, Claudia Jourdan, Stefan RüttermannORCiDGND
Parent Title (English):Polymers
Place of publication:Basel
Document Type:Article
Date of Publication (online):2021/08/21
Date of first Publication:2021/08/21
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2021/09/22
Tag:Poly-Pore; antiadhesive composites; antibacterial composites; bacterial viability; clinical trial; live/dead staining; split-mouth
Issue:16, art. 2814
Page Number:13
First Page:1
Last Page:13
This research was supported by the DFG Deutsche Forschungsgemeinschaft, Bonn, Germany (project no. RU 825/3-1).
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0