Low-dose radiation therapy for COVID-19 pneumopathy: what is the evidence?

  • In the current dismal situation of the COVID-19 pandemic, effective management of patients with pneumonia and acute respiratory distress syndrome is of vital importance. Due to the current lack of effective pharmacological concepts, this situation has caused interest in (re)considering historical reports on the treatment of patients with low-dose radiation therapy for pneumonia. Although these historical reports are of low-level evidence per se, hampering recommendations for decision-making in the clinical setting, they indicate effectiveness in the dose range between 0.3 and 1 Gy, similar to more recent dose concepts in the treatment of acute and chronic inflammatory/degenerative benign diseases with, e.g., a single dose per fraction of 0.5 Gy. This concise review aims to critically review the evidence for low-dose radiation treatment of COVID-19 pneumopathy and discuss whether it is worth investigating in the present clinical situation.
Author:Franz RödelORCiDGND, Meritxell ArenasORCiD, Oliver OttORCiDGND, Claudia FournierORCiDGND, Alexandros G. GeorgakilasORCiD, Soile TapioORCiDGND, Klaus-Rüdiger TrottGND, Udo Sebastian GaiplORCiDGND
Parent Title (German):Strahlentherapie und Onkologie
Publisher:Springer Medizin
Place of publication:Berlin ; Heidelberg
Document Type:Article
Date of Publication (online):2020/05/09
Date of first Publication:2020/05/09
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2022/06/28
Tag:Anti-inflammatory; COVID-19; Low-dose radiation therapy; Pneumonia; SARS-CoV-2
Page Number:4
First Page:679
Last Page:682
Open Access funding provided by Projekt DEAL.
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 53 Physik / 530 Physik
5 Naturwissenschaften und Mathematik / 57 Biowissenschaften; Biologie / 570 Biowissenschaften; Biologie
6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - Namensnennung 4.0