Insights from binding on quadruplex selective carbazole ligands

  • Polymorphic G-quadruplex (G4) secondary DNA structures have received increasing attention in medicinal chemistry owing to their key involvement in the regulation of the maintenance of genomic stability, telomere length homeostasis and transcription of important proto-oncogenes. Different classes of G4 ligands have been developed for the potential treatment of several human diseases. Among them, the carbazole scaffold with appropriate side chain appendages has attracted much interest for designing G4 ligands. Because of its large and rigid π-conjugation system and ease of functionalization at three different positions, a variety of carbazole derivatives have been synthesized from various natural or synthetic sources for potential applications in G4-based therapeutics and biosensors. Herein, we provide an updated close-up of the literatures on carbazole-based G4 ligands with particular focus given on their detailed binding insights studied by NMR spectroscopy. The structure-activity relationships and the opportunities and challenges of their potential applications as biosensors and therapeutics are also discussed. This review will provide an overall picture of carbazole ligands with remarkable G4 topological preference, fluorescence properties and significant bioactivity; portraying carbazole as a very promising scaffold for assembling G4 ligands with a range of novel functional applications.
Author:Diana Müller, Puja Saha, Deepanjan Panda, Jyotirmayee Dash, Harald SchwalbeORCiDGND
Parent Title (English):Chemistry - a European journal
Place of publication:Weinheim
Document Type:Article
Date of Publication (online):2021/06/17
Date of first Publication:2021/06/17
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2022/04/05
Tag:G-quadruplexes; NMR spectroscopy; biophysics; carbazole ligands; ligand design
Page Number:11
First Page:12726
Last Page:12736
D.M. and H.S. were supported by DFG CRC902 and by iNEXT, project number 653706, funded by the Horizon 2020 program of the European Union. Work at BMRZ is supported by the state of Hesse. JD thanks Wellcome Trust-DBT India Alliance [Grant Number, IA/S/18/2/503986] and CSIR-INDIA for research funding. Open access funding enabled and organized by Projekt DEAL.
Institutes:Biochemie, Chemie und Pharmazie
Wissenschaftliche Zentren und koordinierte Programme / Zentrum für Biomolekulare Magnetische Resonanz (BMRZ)
Dewey Decimal Classification:5 Naturwissenschaften und Mathematik / 54 Chemie / 540 Chemie und zugeordnete Wissenschaften
Licence (German):License LogoCreative Commons - Namensnennung 4.0