Complexity of danger: the diverse nature of damage-associated molecular patterns

  • In reply to internal or external danger stimuli, the body orchestrates an inflammatory response. The endogenous triggers of this process are the damage-associated molecular patterns (DAMPs). DAMPs represent a heterogeneous group of molecules that draw their origin either from inside the various compartments of the cell or from the extracellular space. Following interaction with pattern recognition receptors in cross-talk with various non-immune receptors, DAMPs determine the downstream signaling outcome of septic and aseptic inflammatory responses. In this review, the diverse nature, structural characteristics, and signaling pathways elicited by DAMPs will be critically evaluated.

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Author:Liliana SchäferORCiD
Pubmed Id:
Parent Title (English):Journal of biological chemistry
Publisher:American Society for Biochemistry and Molecular Biology Publications
Place of publication:Bethesda, Md
Document Type:Article
Date of Publication (online):2021/01/04
Year of first Publication:2014
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2023/11/08
Tag:ATP; Autophagy; Biglycan; Decorin; Heat Shock Protein (HSP); Heparan Sulfate; Hyaluronan; Inflammasome; Necrosis (Necrotic Death); Small Leucine-rich Proteoglycan (SLRP); Toll-like Receptor (TLR)
Page Number:9
First Page:35237
Last Page:35245
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International