Adult-type and pediatric-type diffuse gliomas

  • The classification of diffuse gliomas into the adult type and the pediatric type is the new basis for the diagnosis and clinical evaluation. The knowledge for the neuroradiologist should not remain limited to radiological aspects but should be based additionally on the current edition of the World Health Organization (WHO) classification of tumors of the central nervous system (CNS). This classification defines the 11 entities of diffuse gliomas, which are included in the 3 large groups of adult-type diffuse gliomas, pediatric-type diffuse low-grade gliomas, and pediatric-type diffuse high-grade gliomas. This article provides a detailed overview of important molecular, morphological, and clinical aspects for all 11 entities, such as typical genetic alterations, age distribution, variability of the tumor localization, variability of histopathological and radiological findings within each entity, as well as currently available statistical information on prognosis and outcome. Important differential diagnoses are also discussed.

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Author:Reinhold NafeORCiD, Luciana PortoORCiDGND, Patrick-Felix SampORCiDGND, Se-Jong YouGND, Elke HattingenORCiDGND
URN:urn:nbn:de:hebis:30:3-869352
DOI:https://doi.org/10.1007/s00062-023-01277-z
ISSN:1869-1447
Pubmed Id:https://pubmed.ncbi.nlm.nih.gov/36941392
Parent Title (English):Clinical neuroradiology
Publisher:Springer
Place of publication:Berlin ; Heidelberg
Document Type:Article
Language:English
Date of Publication (online):2023/03/20
Date of first Publication:2023/03/20
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2024/10/30
Tag:Astrocytomas; Diffuse hemispheric gliomas; Diffuse midline gliomas; Glioblastomas; Oligodendrogliomas
Volume:33
Issue:3
Page Number:14
First Page:611
Last Page:624
Institutes:Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International