Maximilian Nikolai Kinzler, Katrin Bankov, Julia Bein, Claudia Döring, Falko Schulze, Henning Reis, Scherwin Mahmoudi, Vitali Koch, Leon David Grünewald, Angelika Tianming Martina Roswitha Stehle, Dirk Walter, Fabian Finkelmeier, Stefan Zeuzem, Peter Johannes Wild, Thomas J. Vogl, Simon Bernatz
- Distinct immune patterns of hepatocellular carcinoma (HCC) may have prognostic implications in the response to transarterial chemoembolization (TACE). Thus, we aimed to exploratively analyze tumor tissue of HCC patients who do or do not respond to TACE, and to identify novel prognostic biomarkers predictive of response to TACE. We retrospectively included 15 HCC patients who had three consecutive TACE between January 2019 and November 2019. Eight patients had a response while seven patients had no response to TACE. All patients had measurable disease according to mRECIST. Corresponding tumor tissue samples were processed for differential expression profiling using NanoString nCounter® PanCancer immune profiling panel. Immune-related pathways were broadly upregulated in TACE responders. The top differentially regulated genes were the upregulated CXCL1 (log2fc 4.98, Benjamini–Hochberg (BH)-p < 0.001), CXCL6 (log2fc 4.43, BH-p = 0.016) and the downregulated MME (log2fc −4.33, BH-p 0.001). CD8/T-regs was highly increased in responders, whereas the relative number of T-regs to tumor-infiltrating lymphocytes (TIL) was highly decreased. We preliminary identified CXCL1 and CXCL6 as candidate genes that might have the potential to serve as therapeutically relevant biomarkers in HCC patients. This might pave the way to improve patient selection for TACE in HCC patients beyond expert consensus.
MetadatenAuthor: | Maximilian Nikolai KinzlerORCiDGND, Katrin BankovORCiDGND, Julia Bein, Claudia DöringORCiDGND, Falko SchulzeGND, Henning ReisORCiDGND, Scherwin MahmoudiGND, Vitali KochORCiDGND, Leon David GrünewaldORCiDGND, Angelika Tianming Martina Roswitha StehleGND, Dirk WalterORCiD, Fabian FinkelmeierORCiDGND, Stefan ZeuzemORCiDGND, Peter Johannes WildORCiDGND, Thomas J. VoglORCiDGND, Simon BernatzORCiDGND |
---|
URN: | urn:nbn:de:hebis:30:3-870416 |
---|
DOI: | https://doi.org/10.3390/curroncol30030267 |
---|
ISSN: | 1718-7729 |
---|
Parent Title (English): | Current oncology |
---|
Publisher: | Multimed |
---|
Place of publication: | Toronto, Ontario |
---|
Document Type: | Article |
---|
Language: | English |
---|
Date of Publication (online): | 2023/03/20 |
---|
Date of first Publication: | 2023/03/20 |
---|
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
---|
Release Date: | 2024/09/18 |
---|
Tag: | biomarker; hepatocellular carcinoma; immune profiling; transarterial chemoembolization |
---|
Volume: | 30 |
---|
Issue: | 3 |
---|
Page Number: | 13 |
---|
First Page: | 3516 |
---|
Last Page: | 3528 |
---|
Note: | Funding: Faculty of Medicine of the Goethe University Frankfurt Research Promotion Program (FFF) |
---|
Note: | Funding: Faculty of Medicine of the Goethe University; Stiftungen und Vereine–Stiftungsmittel des Fachbereichs |
---|
Note: | Gefördert durch den Open-Access-Publikationsfonds der Goethe-Universität. |
---|
HeBIS-PPN: | 52229636X |
---|
Institutes: | Medizin |
---|
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
---|
Sammlungen: | Universitätspublikationen |
---|
Open-Access-Publikationsfonds: | Medizin |
---|
Licence (German): | Creative Commons - CC BY - Namensnennung 4.0 International |
---|