CXCL1 and CXCL6 are potential predictors for HCC response to TACE

  • Distinct immune patterns of hepatocellular carcinoma (HCC) may have prognostic implications in the response to transarterial chemoembolization (TACE). Thus, we aimed to exploratively analyze tumor tissue of HCC patients who do or do not respond to TACE, and to identify novel prognostic biomarkers predictive of response to TACE. We retrospectively included 15 HCC patients who had three consecutive TACE between January 2019 and November 2019. Eight patients had a response while seven patients had no response to TACE. All patients had measurable disease according to mRECIST. Corresponding tumor tissue samples were processed for differential expression profiling using NanoString nCounter® PanCancer immune profiling panel. Immune-related pathways were broadly upregulated in TACE responders. The top differentially regulated genes were the upregulated CXCL1 (log2fc 4.98, Benjamini–Hochberg (BH)-p < 0.001), CXCL6 (log2fc 4.43, BH-p = 0.016) and the downregulated MME (log2fc −4.33, BH-p 0.001). CD8/T-regs was highly increased in responders, whereas the relative number of T-regs to tumor-infiltrating lymphocytes (TIL) was highly decreased. We preliminary identified CXCL1 and CXCL6 as candidate genes that might have the potential to serve as therapeutically relevant biomarkers in HCC patients. This might pave the way to improve patient selection for TACE in HCC patients beyond expert consensus.
Metadaten
Author:Maximilian Nikolai KinzlerORCiDGND, Katrin BankovORCiDGND, Julia Bein, Claudia DöringORCiDGND, Falko SchulzeGND, Henning ReisORCiDGND, Scherwin MahmoudiGND, Vitali KochORCiDGND, Leon David GrünewaldORCiDGND, Angelika Tianming Martina Roswitha StehleGND, Dirk WalterORCiD, Fabian FinkelmeierORCiDGND, Stefan ZeuzemORCiDGND, Peter Johannes WildORCiDGND, Thomas J. VoglORCiDGND, Simon BernatzORCiDGND
URN:urn:nbn:de:hebis:30:3-870416
DOI:https://doi.org/10.3390/curroncol30030267
ISSN:1718-7729
Parent Title (English):Current oncology
Publisher:Multimed
Place of publication:Toronto, Ontario
Document Type:Article
Language:English
Date of Publication (online):2023/03/20
Date of first Publication:2023/03/20
Publishing Institution:Universitätsbibliothek Johann Christian Senckenberg
Release Date:2024/09/18
Tag:biomarker; hepatocellular carcinoma; immune profiling; transarterial chemoembolization
Volume:30
Issue:3
Page Number:13
First Page:3516
Last Page:3528
Note:
Funding: Faculty of Medicine of the Goethe University Frankfurt Research Promotion Program (FFF)
Note:
Funding: Faculty of Medicine of the Goethe University; Stiftungen und Vereine–Stiftungsmittel des Fachbereichs
Note:
Gefördert durch den Open-Access-Publikationsfonds der Goethe-Universität.
HeBIS-PPN:52229636X
Institutes:Medizin
Dewey Decimal Classification:6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit
Sammlungen:Universitätspublikationen
Open-Access-Publikationsfonds:Medizin
Licence (German):License LogoCreative Commons - CC BY - Namensnennung 4.0 International