Global impact of proteoglycan science on human diseases
- In this comprehensive review, we will dissect the impact of research on proteoglycans focusing on recent developments involved in their synthesis, degradation, and interactions, while critically assessing their usefulness in various biological processes. The emerging roles of proteoglycans in global infections, specifically the SARS-CoV-2 pandemic, and their rising functions in regenerative medicine and biomaterial science have significantly affected our current view of proteoglycans and related compounds. The roles of proteoglycans in cancer biology and their potential use as a next-generation protein-based adjuvant therapy to combat cancer is also emerging as a constructive and potentially beneficial therapeutic strategy. We will discuss the role of proteoglycans in selected and emerging areas of proteoglycan science, such as neurodegenerative diseases, autophagy, angiogenesis, cancer, infections and their impact on mammalian diseases.
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| Author: | Christopher XieORCiD, Liliana SchäferORCiD, Renato V. IozzoORCiDGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-791544 |
| DOI: | https://doi.org/10.1016/j.isci.2023.108095 |
| ISSN: | 2589-0042 |
| Parent Title (English): | iScience |
| Publisher: | Elsevier |
| Place of publication: | Amsterdam |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2023/10/13 |
| Date of first Publication: | 2023/10/13 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2023/10/16 |
| Tag: | Cell surface proteoglycans; SARS-CoV-2; angiogenesis; autophagy; cancer; inflammation; neurodegenerative diseases; small leucine-rich proteoglycans |
| Volume: | 26 |
| Issue: | 108095 |
| Article Number: | 108095 |
| Page Number: | 19 |
| HeBIS-PPN: | 516390783 |
| Institutes: | Medizin |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - CC BY-NC-ND - Namensnennung - Nicht kommerziell - Keine Bearbeitungen 4.0 International |
