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First description of immune complex vasculitis after COVID-19 vaccination with BNT162b2: a case report
- Background: Cases of immune complex vasculitis have been reported following COVID-19 infections; so far none in association with novel mRNA-based COVID-19 vaccination. This case report describes a cutaneous immune complex vasculitis after vaccination with BNT162b2. Case presentation: A 76-year old male with liver cirrhosis developed an immune complex vasculitis 12 days after the second injection of BNT162b2. On physical examination, the patient presented with pruritic purpuric macules on hands and feet, flexor and extensor parts of both legs and thighs and lower abdomen, and bloody diarrhoea. Laboratory testing showed elevated inflammatory markers. After short treatment with oral steroids all clinical manifestations and laboratory findings resolved. Conclusions: An increasing number of clinical manifestations have been attributed to COVID-19 infection and vaccination. This is the first written report of immune complex vasculitis after vaccination with BNT162b2. We present our case report and a discussion in the light of type three hypersensitivity reaction.
Author: | Victoria Therese MückeORCiDGND, Viola Knop, Marcus Maximilian MückeORCiDGND, Falk OchsendorfORCiDGND, Stefan ZeuzemORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-645628 |
DOI: | https://doi.org/10.1186/s12879-021-06655-x |
ISSN: | 1471-2334 |
Parent Title (English): | BMC infectious diseases |
Publisher: | BioMed Central |
Place of publication: | London |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2021/09/16 |
Date of first Publication: | 2021/09/16 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Release Date: | 2022/02/11 |
Tag: | BNT162b2; COVID-19 vaccination; Case report; Immune complex vasculitis; Type three hypersensitivity |
Volume: | 21 |
Issue: | art. 958 |
Page Number: | 6 |
First Page: | 1 |
Last Page: | 6 |
Note: | Open Access funding enabled and organized by Projekt DEAL. |
Note: | The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
HeBIS-PPN: | 492017018 |
Institutes: | Medizin |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Sammlungen: | Universitätspublikationen |
Licence (German): | Creative Commons - Namensnennung 4.0 |