Macrophage and tumor cell cross-talk is fundamental for lung tumor progression: we need to talk
- Regardless of the promising results of certain immune checkpoint blockers, current immunotherapeutics have met a bottleneck concerning response rate, toxicity, and resistance in lung cancer patients. Accumulating evidence forecasts that the crosstalk between tumor and immune cells takes center stage in cancer development by modulating tumor malignancy, immune cell infiltration, and immune evasion in the tumor microenvironment (TME). Cytokines and chemokines secreted by this crosstalk play a major role in cancer development, progression, and therapeutic management. An increased infiltration of Tumor-associated macrophages (TAMs) was observed in most of the human cancers, including lung cancer. In this review, we emphasize the role of cytokines and chemokines in TAM-tumor cell crosstalk in the lung TME. Given the role of cytokines and chemokines in immunomodulation, we propose that TAM-derived cytokines and chemokines govern the cancer-promoting immune responses in the TME and offer a new immunotherapeutic option for lung cancer treatment.
| Author: | Poonam Ashwin Kumar SarodeORCiDGND, Martina Barbara Schaefer, Friedrich GrimmingerORCiDGND, Werner SeegerORCiDGND, Rajkumar SavaiORCiDGND |
|---|---|
| URN: | urn:nbn:de:hebis:30:3-544782 |
| DOI: | https://doi.org/10.3389/fonc.2020.00324 |
| Pubmed Id: | https://pubmed.ncbi.nlm.nih.gov/32219066 |
| Parent Title (English): | Frontiers in oncology |
| Publisher: | Frontiers Research Foundation |
| Place of publication: | Lausanne |
| Document Type: | Article |
| Language: | English |
| Date of Publication (online): | 2020/03/11 |
| Date of first Publication: | 2020/03/11 |
| Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
| Release Date: | 2020/04/09 |
| Tag: | chemokines; cytokines; lung cancer; tumor microenvironment; tumor-associated macrophages |
| Volume: | 10 |
| Issue: | 324 |
| Page Number: | 11 |
| Note: | Copyright © 2020 Sarode, Schaefer, Grimminger, Seeger and Savai. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| HeBIS-PPN: | 464702895 |
| Institutes: | Medizin / Medizin |
| Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
| Sammlungen: | Universitätspublikationen |
| Licence (German): |  Creative Commons - Namensnennung 4.0 |
