- Background: An experienced life-threating anaphylactic reaction to hymenoptera venom can sustainably impair patients’ quality of life (QoL). Besides carrying emergency medication, venom-specific immunotherapy (VIT) exists as a causal treatment of allergy.
Objective: This study aimed to examine QoL, anxiety, depression, and physical and mental health in patients allergic to hymenoptera venom before and during VIT and the impact of a tolerated sting challenge (SC).
Methods: Between July 2017 and August 2017, 142 patients with venom allergy were analyzed using validated questionnaires as the: Vespid Allergy Quality for Life Questionnaire" (VQLQ-d), the "Hospital Anxiety and Depression Scale" (HADS-D) and the "Short Form 36" (SF-36). To evaluate the impact of VIT and SC on the QoL, patients were divided into 3 groups: (A) VIT and tolerated SC (n = 45), (B) VIT before carrying out SC (n = 73), and (C) therapy-naïve before VIT (n = 20). Further parameters like gender, age, insect species, and severity of the anaphylactic reaction were assessed.
Results: A significant correlation between the health-related QoL and the parameters of gender and state of treatment was seen. Especially male patients, as well as patients allergic to yellow jacket venom, benefit from a SC in terms of a significant increase in their QoL. In the total study cohort, a clear trend was observed towards a higher QoL in patients under VIT who tolerated a SC. Overall, neither the patients’ age nor the insect species exerted a relevant influence on QoL, depression or anxiety. However, women showed a lower QoL combined with higher anxiety and depression scores than men.
Conclusion: Immunotherapy leads to an improved QoL, which can be further increased by a SC. A tolerated SC conceivably reassures the patients by objectifying the treatment success. Female patients appear to have a stronger impaired QoL per se. Taken together, a SC can be performed during VIT to strengthen the patients’ QoL.
MetadatenVerfasserangaben: | Tamara Rebecca EitelGND, Kim Nikola ZeinerGND, Katharina Aßmus, Hanns AckermannGND, Nadja Nicole ZöllerORCiDGND, Markus MeissnerORCiDGND, Roland KaufmannGND, Stefan KippenbergerORCiDGND, Eva Maria ValeskyORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-779082 |
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DOI: | https://doi.org/10.1016/j.waojou.2021.100536 |
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ISSN: | 1939-4551 |
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Titel des übergeordneten Werkes (Englisch): | World Allergy Organization Journal |
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Verlag: | Elsevier |
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Verlagsort: | Amsterdam |
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Dokumentart: | Wissenschaftlicher Artikel |
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Sprache: | Englisch |
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Datum der Veröffentlichung (online): | 21.04.2021 |
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Datum der Erstveröffentlichung: | 21.04.2021 |
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Veröffentlichende Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Datum der Freischaltung: | 01.11.2023 |
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Freies Schlagwort / Tag: | Hymenoptera venom allergy; Immunotherapy; Quality of life; Sting challenge |
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Jahrgang: | 14 |
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Ausgabe / Heft: | 5, art. 100536 |
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Aufsatznummer: | 100536 |
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Seitenzahl: | 13 |
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HeBIS-PPN: | 515680273 |
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Institute: | Medizin |
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DDC-Klassifikation: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Lizenz (Deutsch): | Creative Commons - CC BY - Namensnennung 4.0 International |
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