- Highlights
• Hyperglycaemia, in rodents, is consistently associated with cognitive impairments.
• The strength of this association is supported by the heterogeneity of the studies.
• The study of the role of insulin on cognition is mainly limited to spatial memory.
• Preclinical studies on the role of insulin signalling on cognition are male biased.
Abstract
Beside its involvement in somatic dysfunctions, altered insulin signalling constitutes a risk factor for the development of mental disorders like Alzheimer’s disease and obsessive-compulsive disorder. While insulin-related somatic and mental disorders are often comorbid, the fundamental mechanisms underlying this association are still elusive. Studies conducted in rodent models appear well suited to help decipher these mechanisms. Specifically, these models are apt to prospective studies in which causative mechanisms can be manipulated via multiple tools (e.g., genetically engineered models and environmental interventions), and experimentally dissociated to control for potential confounding factors. Here, we provide a narrative synthesis of preclinical studies investigating the association between hyperglycaemia – as a proxy of insulin-related metabolic dysfunctions – and impairments in working and spatial memory, and attention. Ultimately, this review will advance our knowledge on the role of glucose metabolism in the comorbidity between somatic and mental illnesses.
MetadatenAuthor: | Angela Maria OttomanaORCiD, Martina PrestaORCiD, Aet O'LearyORCiDGND, Mairéad Sullivan, Edoardo PisaORCiD, Giovanni LaviolaORCiD, Jeffrey C. GlennonORCiD, Francesca ZorattoORCiD, David A. SlatteryORCiDGND, Simone Macrì |
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URN: | urn:nbn:de:hebis:30:3-833967 |
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DOI: | https://doi.org/10.1016/j.neubiorev.2023.105435 |
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ISSN: | 0149-7634 |
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Parent Title (English): | Neuroscience and biobehavioral reviews |
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Publisher: | Elsevier |
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Place of publication: | Amsterdam |
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Document Type: | Article |
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Language: | English |
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Date of Publication (online): | 2023/11/11 |
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Date of first Publication: | 2023/10/31 |
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Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Release Date: | 2024/03/22 |
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Tag: | Animal models; Comorbidity; Insulin signalling; Mental health; Systematic review |
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Volume: | 155 |
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Issue: | 105435 |
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Article Number: | 105435 |
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Page Number: | 32 |
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HeBIS-PPN: | 519220900 |
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Institutes: | Medizin |
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Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Licence (German): | Creative Commons - Namensnennung 4.0 |
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