Endothelial microRNAs and long noncoding RNAs in cardiovascular ageing
- Highlights • Endothelial ageing contributes significantly to atherosclerosis. • Non-coding RNAs are gaining interest as regulators of vascular biology. • Several microRNAs regulate endothelial cell ageing. • Multiple lncRNAs play a role in endothelial cell ageing. Abstract Atherosclerosis and numerous other cardiovascular diseases develop in an age-dependent manner. The endothelial cells that line the vessel walls play an important role in the development of atherosclerosis. Non-coding RNA like microRNAs and long non-coding RNAs are known to play an important role in endothelial function and are implicated in the disease progression. Here, we summarize several microRNAs and long non-coding RNAs that are known to have an altered expression with endothelial aging and discuss their role in endothelial cell function and senescence. These processes contribute to aging-induced atherosclerosis development and by targeting the non-coding RNAs controlling endothelial cell function and senescence, atherosclerosis can potentially be attenuated.
Author: | Diewertje I. BinkORCiD, Jessica PauliORCiD, Lars MägdefesselORCiDGND, Reinier BoonORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-789565 |
DOI: | https://doi.org/10.1016/j.atherosclerosis.2023.03.019 |
ISSN: | 0021-9150 |
Parent Title (English): | Atherosclerosis |
Publisher: | Elsevier |
Place of publication: | Amsterdam |
Document Type: | Article |
Language: | English |
Date of Publication (online): | 2023/06/15 |
Date of first Publication: | 2023/04/05 |
Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
Release Date: | 2024/04/12 |
Tag: | Ageing; Endothelial cells; Non-coding RNA; lncRNA; microRNA |
Volume: | 374 |
Page Number: | 8 |
First Page: | 99 |
Last Page: | 106 |
HeBIS-PPN: | 520899393 |
Institutes: | Medizin |
Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
Sammlungen: | Universitätspublikationen |
Licence (German): | Creative Commons - Namensnennung 4.0 |