- Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease of the hair follicles leading to painful lesions, associated with increased levels of pro-inflammatory cytokines. Numerous guidelines recommend antibiotics like clindamycin and rifampicin in combination, as first-line systemic therapy in moderate-to-severe forms of inflammation. HS has been proposed to be mainly an auto-inflammatory disease associated with but not initially provoked by bacteria. Therefore, it has to be assumed that the pro-inflammatory milieu previously observed in HS skin is not solely dampened by the bacteriostatic inhibition of DNA-dependent RNA polymerase. To further clarify the mechanism of anti-inflammatory effects of rifampicin, ex vivo explants of lesional HS from 8 HS patients were treated with rifampicin, and its effect on cytokine production, immune cells as well as the expression of Toll-like receptor 2 (TLR2) were investigated. Analysis of cell culture medium of rifampicin-treated HS explants revealed an anti-inflammatory effect of rifampicin that significantly inhibiting interleukin (IL)-1β, IL-6, IL-8, IL-10 and tumour necrosis factor (TNF)-α production. Immunohistochemistry of the rifampicin-treated explants suggested a tendency for it to reduce the expression of TLR2 while not affecting the number of immune cells.
MetadatenAuthor: | Isabel HaferlandORCiDGND, Chantal M. WallenweinGND, Tanja Ickelsheimer, Sandra DiehlORCiD, Matthias WackerORCiDGND, Susanne SchiffmannORCiDGND, Claudia BürgerORCiDGND, Roland KaufmannGND, Anke KönigGND, Andreas PinterORCiDGND |
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URN: | urn:nbn:de:hebis:30:3-753627 |
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DOI: | https://doi.org/10.1111/exd.14531 |
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ISSN: | 1600-0625 |
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Parent Title (English): | Experimental dermatology |
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Publisher: | Wiley-Blackwell |
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Place of publication: | Oxford |
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Document Type: | Article |
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Language: | English |
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Date of Publication (online): | 2022/01/20 |
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Date of first Publication: | 2022/01/20 |
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Publishing Institution: | Universitätsbibliothek Johann Christian Senckenberg |
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Release Date: | 2023/09/07 |
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Tag: | anti-bacterial agents; anti-inflammatory agent; hidradenitis suppurativa; rifampin; therapeutics |
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Volume: | 31 |
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Issue: | 7 |
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Page Number: | 9 |
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First Page: | 1005 |
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Last Page: | 1013 |
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Note: | Open access funding enabled and organized by Projekt DEAL. |
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HeBIS-PPN: | 51297991X |
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Institutes: | Medizin |
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Dewey Decimal Classification: | 6 Technik, Medizin, angewandte Wissenschaften / 61 Medizin und Gesundheit / 610 Medizin und Gesundheit |
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Sammlungen: | Universitätspublikationen |
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Licence (German): | Creative Commons - CC BY-NC - Namensnennung - Nicht kommerziell 4.0 International |
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